Phenethyl caffeate | 咖啡酸苯乙酯 | Caffeic acid phenethyl ester | Apoptosis Inducer

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CAPE (咖啡酸苯乙酯) /Phenethyl caffeate 98%

货号：A158279 同义名： 咖啡酸苯乙酯 / Caffeic acid phenethyl ester;CAPE

Caffeic acid phenethyl ester, a natural product isolated and purified from the barks of Cinnamomum cassia Presl, is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities.

Phenethyl caffeate 化学结构
CAS号：104594-70-9

Phenethyl caffeate 3D分子结构
CAS号：104594-70-9

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Phenethyl caffeate 纯度/质量文件产品仅供科研

货号：A158279 标准纯度： 98% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

NF-κB 亚型比较

产品名称	NF-κB ↓ ↑	其他靶点	纯度
Pyrrolidinedithiocarbamate ammonium	✔		98%
QNZ	++++ NF-κB, IC50: 11 nM		99%+
Sodium 4-Aminosalicylate Dihydrate	✔		98%
Sodium Salicylate	✔		95%
Parthenolide	✔	p53	97% HPLC
JSH-23	+ NF-κB, IC50: 7.1 μM		98%
Phenethyl caffeate	✔		98%
Andrographolide	✔		98+%
Curcumin	✔	Nrf2,HDAC	98%
SC75741	+++ NF-κB, EC50: 200 nM		99%+
CBL0137 HCl	++ NF-κB, EC50: 0.47 μM	p53	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Phenethyl caffeate 生物活性

靶点

NF-κB

描述

NF-κB is a transcription factor with heterodimer or homodimer form of rel family proteins including RelA (p65), RelB, cRel, p50 and p52. Caffeic Acid Phenethyl Ester (CAPE) is an NF-κB inhibitor isolated from propolis. Treatment with CAPE at concentration ranging in 20-40μM for 2h could dose-dependently inhibit phosphorylation of IκBα and subsequently nuclear translocation of NF-κB (present as p65) induced by LPS in hepatic stellate cells. The increased nitrite production and the transcription and protein synthesis of MCP-1, IL-6 and iNOS induced by LPS could be significantly reduced by CAPE at concentration ranging in 5-40μM in a concentration-dependent manner in the same cells. Similarly, TNF-activated binding of NF-κB to DNA, phosphorylation of IκBα (within 30min) and p65 nuclear translocation could be observed in U937 cells pre-treated with 25μg/ml CAPE. Oral administration of 30mg/kg of CAPE daily for 4 weeks could improve the glucose sensitivity associated with the improvement in insulin-stimulated phosphorylation of the insulin receptor substrate-2 and an increase in Akt phosphorylation, promote amelioration in hepaticsteatosis, as well as reduced the induction of the inflammatory pathway, including JNK, NF-κB and COX-2 pathway, in high-fat-diet mice.

Phenethyl caffeate 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
human A549 cells		Cytotoxic assay	72 h	Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=26.8 μM	20673727
human BCG823 cells		Cytotoxic assay		Cytotoxicity against human BCG823 cells by MTT assay, IC50=44.6 μM	18952420
human Bel7402 cells		Cytotoxic assay		Cytotoxicity against human Bel7402 cells by MTT assay, IC50=5.5 μM	18952420
human Bel7404 cells		Cytotoxic assay	72 h	Cytotoxicity against human Bel7404 cells after 72 hrs by MTT assay, IC50=14.5 μM	20673727

Phenethyl caffeate 动物研究

Dose

Rat: 3 mg/kg, 6 mg/kg^[3] (i.p.); 1 mg/kg - 20 mg/kg^[4] (i.v.); 20 μg/kg/day^[5] (p.o.) Pups: 40 mg/kg^[6] (i.p.)

Administration

i.p., i.v., p.o.

Pharmacokinetics

Animal	Rats^[7]
Dose	20 mg/kg
Administration	i.v.
CL_t	148.2 ± 70.4 ml/min/kg
T_1/2	28.7 ± 9.1 min
B	1.071 ± 0.926 μg/ml
α	0.468 ± 0.038 min^-1
V_z	5784 ± 2579 min/kg
A	53.6 ± 15.6 μg/ml
AUC_∞	160.5 ± 74.4 μg·min/ml
β	0.027 ± 0.011 min^-1

Phenethyl caffeate 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02744703	Matrix Metalloproteinase Inhib... 展开 >>itors Composite Resins 收起 <<	Not Applicable	Completed	-	-

Phenethyl caffeate 参考文献

[1]Banskota AH, Nagaoka T, et al. Antiproliferative activity of the Netherlands propolis and its active principles in cancer cell lines. J Ethnopharmacol. 2002 Apr;80(1):67-73.

[2]Natarajan K, Singh S, et al. Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9090-5.

[3]Kumar M, Kaur D, et al. Caffeic Acid Phenethyl Ester (CAPE) Prevents Development of STZ-ICV Induced dementia in Rats. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S10-S15.

[4]Iraz M, Fadillioglu E, et al. Role of vagal activity on bradicardic and hypotensive effects of caffeic acid phenethyl ester (CAPE). Cardiovasc Toxicol. 2005 Fall;5(4):391-6.

[5]Bozkurt Y, Bozkurt M, et al. Caffeic acid phenethyl ester protects kidneys against acetylsalicylic acid toxicity in rats. Ren Fail. 2012;34(9):1150-5.

[6]Wei X, Zhao L, et al. Caffeic acid phenethyl ester prevents neonatal hypoxic-ischaemic brain injury. Brain. 2004 Dec;127(Pt 12):2629-35. Epub 2004 Oct 6.

[7]Wang X, Pang J, et al. Pharmacokinetics of caffeic acid phenethyl ester and its catechol-ring fluorinated derivative following intravenous administration to rats. Biopharm Drug Dispos. 2009 Jul;30(5):221-8.

Phenethyl caffeate 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.17mL

7.03mL

3.52mL

Phenethyl caffeate 技术信息

CAS号	104594-70-9
分子式	C₁₇H₁₆O₄
分子量	284.31

别名	咖啡酸苯乙酯 ;Caffeic acid phenethyl ester;CAPE;BAF-IN-C09;β-Phenylethyl Caffeate;2-Phenylethyl Caffeate;Caffeic Acid phenylethyl ester;Phenylethyl Caffeate
运输	蓝冰

存储条件

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(369.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

human A549 cells		Cytotoxic assay	72 h	Cytotoxicity against human A549 cells after 72 hrs by MTT assay, IC50=26.8 μM	20673727
human BCG823 cells		Cytotoxic assay		Cytotoxicity against human BCG823 cells by MTT assay, IC50=44.6 μM	18952420
human Bel7402 cells		Cytotoxic assay		Cytotoxicity against human Bel7402 cells by MTT assay, IC50=5.5 μM	18952420
human Bel7404 cells		Cytotoxic assay	72 h	Cytotoxicity against human Bel7404 cells after 72 hrs by MTT assay, IC50=14.5 μM	20673727
human Bewo cells		Function assay		Antitumor activity against human Bewo cells assessed as inhibition of cell growth by MTT assay, IC50=2.96 μM	25160837
human BGC823 cells		Cytotoxic assay	72 h	Cytotoxicity against human BGC823 cells after 72 hrs by MTT assay, IC50=19.3 μM	20673727
human ECA109 cells		Cytotoxic assay	72 h	Cytotoxicity against human ECA109 cells after 72 hrs by MTT assay, IC50=42.6 μM	20673727
human HeLa cells		Proliferation assay	72 h	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay, EC50=2.36 μM	12027739
human HeLa cells		Function assay		Antitumor activity against human HeLa cells assessed as inhibition of cell growth by MTT assay, IC50=37.98 μM	25160837
human HepG2 cells		Function assay		Antitumor activity against human HepG2 cells assessed as inhibition of cell growth by MTT assay, IC50=40.87 μM	25160837
human HL60 cells		Cytotoxic assay	72 h	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay, IC50=9.8 μM	20673727
human HO8910 cells		Cytotoxic assay	72 h	Cytotoxicity against human HO8910 cells after 72 hrs by MTT assay, IC50=25.5 μM	20673727
human HT1080 cells		Proliferation assay	72 h	Antiproliferative activity against human HT1080 cells after 72 hrs by MTT assay, EC50=9.5 μM	12027739
human K562 cells		Cytotoxic assay	72 h	Cytotoxicity against human K562 cells after 72 hrs by MTT assay, IC50=46 μM	20673727
human KB cells		Cytotoxic assay	72 h	Cytotoxicity against human KB cells after 72 hrs by MTT assay, IC50=45.2 μM	20673727
human LNCAP cells		Function assay	24 h	Antiandrogenic activity in human LNCAP cells assessed as reduction in DHT-stimulated PSA release after 24 hrs by ELISA, IC50=6.2 nM	24080105
human LNCAP cells		Cytotoxic assay	24 h	Cytotoxicity against human LNCAP cells assessed as reduction in cell viability after 24 hrs by WST-1 assay, IC50=33.7 μM	24080105
human LS 174T cells		Cytotoxic assay	72 h	Cytotoxicity against human LS 174T cells after 72 hrs by MTT assay, IC60=9.9 μM	20673727
human MCF7 cells		Cytotoxic assay		Cytotoxicity against human MCF7 cells by MTT assay, IC50=26.7 μM	18952420
human SGC7901 cells		Function assay		Antitumor activity against human SGC7901 cells assessed as inhibition of cell growth by MTT assay, IC50=14.26 μM	25160837
HUVEC cells		Cytotoxic assay	18 h	Cytoprotective activity against H2O2-induced oxidative stress in HUVEC cells after 18 hrs by Cell-Titer Blue assay	20598894
mouse 26-L5 cells		Proliferation assay	72 h	Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay, EC50=0.3 μM	12027739
mouse B16-BL6 cells		Proliferation assay	72 h	Antiproliferative activity against mouse B16-BL6 cells after 72 hrs by MTT assay, EC50=6.79 μM	12027739
mouse BV2 cells		Function assay	24 h	Inhibition of nitric oxide production in LPS-stimulated mouse BV2 cells treated 3 hrs before LPS addition measured after 24 hrs by Griess assay, IC50=6.4 μM	23870700
mouse J774.1 cells		Function assay	24 h	Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay, IC50=4.8 μM	15974608
mouse RAW264.7 cells		Function assay	24 h	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation administered 1 hr before LPS challenge and measured after 24 hrs by Griess reagent assay, EC50=0.193 μM	18667320
rat PC12 cells	2.5 μM	Function assay	3 h	Neuroprotective activity against H2O2-induced damage in rat PC12 cells assessed as cell viability at 2.5 uM preincubated for 3 hrs followed by H2O2 challenge measured after 5 hrs by MTT assay	24697335
rat VSMC	5 μM	Function assay	30 mins	Decrease in intracellular ROS level in PDGF-stimulated rat VSMC at 5 uM pretreated with compound for 30 mins measured after up to 23 hrs of post stimulation using H2DCF by flow cytometric analysis	21265554

CAPE (咖啡酸苯乙酯) /Phenethyl caffeate 98%

Phenethyl caffeate 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Phenethyl caffeate 质控信息

Phenethyl caffeate 生物活性

Phenethyl caffeate 细胞研究

Phenethyl caffeate 动物研究

Phenethyl caffeate 临床研究

Phenethyl caffeate 参考文献

Phenethyl caffeate 实验方案

Phenethyl caffeate 技术信息

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CAPE (咖啡酸苯乙酯) /Phenethyl caffeate 98%

Phenethyl caffeate 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Phenethyl caffeate 质控信息

Phenethyl caffeate 生物活性

Phenethyl caffeate 细胞研究

Phenethyl caffeate 动物研究

Phenethyl caffeate 临床研究

Phenethyl caffeate 参考文献

Phenethyl caffeate 实验方案

Phenethyl caffeate 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Phenethyl caffeate 纯度/质量文件产品仅供科研