Curcumin, a polyphenol found in turmeric (curcuma longa), has health benefits such as antioxidant, anti-inflammatory, and anticancer properties, improvement of brain function, and control of obesity and diabetes. And dietary curcumin (80 mg kg−1) administered to mice on a high-fat diet significantly lowered the fasting blood glucose levels and TNF-α concentrations, and inhibited the lowering of glucose tolerance[3]. Moreover, cur(curcumin) inhibited hypoxia-induced HIF1α expression and tissue damage by demonstrating the improved morphology of astrocytes and remarkable reduction in vacuolation[4].
Curcumin/姜黄素 细胞实验
Cell Line
Concentration
Treated Time
Description
References
CHO cells
10 µM
24 h
Curcumin significantly reduced the secretion of Aβ40 and Aβ42
Cells. 2020 Feb 3;9(2):349.
SH-SY5Y cells
10 µM
24 h
Curcuminsignificantly reduced the secretion of Aβ40
Cells. 2020 Feb 3;9(2):349.
ARPE-19 cells
0.01 mM
24 h
To evaluate the effect of curcumin on cell proliferation, results showed that 0.01 mM curcumin significantly increased cell proliferation.
Int J Mol Sci. 2022 Nov 25;23(23):14771.
ARPE-19 cells
0.05 mM
24 h
To evaluate the effect of curcumin on cell proliferation, results showed that 0.05 mM curcumin significantly decreased cell viability and triggered S-phase cell cycle arrest.
Int J Mol Sci. 2022 Nov 25;23(23):14771.
ARPE-19 cells
0.1 mM
24 h
To evaluate the effect of curcumin on cell proliferation, results showed that 0.1 mM curcumin significantly decreased cell viability and triggered S-phase cell cycle arrest.
Int J Mol Sci. 2022 Nov 25;23(23):14771.
Human cervical cancer cells (HeLa)
5–50 μM
72 h
To compare the cytotoxicity of free curcumin and FA-CLAP nanocurcumin on HeLa cells. Results showed that FA-CLAP nanocurcumin exhibited higher cytotoxicity at doses of 15 μM, 25 μM, and 50 μM.
J Nanobiotechnology. 2014 Jul 15;12:25.
Human cervical cancer cells (HeLa)
25 μM
2 h
To study the cellular uptake of FA-CLAP nanocurcumin. Results showed that FA-CLAP nanocurcumin exhibited better cellular uptake than free curcumin.
J Nanobiotechnology. 2014 Jul 15;12:25.
4T1 breast cancer cells
6 µg/mL
1, 2, and 4 h
To evaluate the cellular uptake of CUR/IR780@SMEDDS, results showed that the uptake of CUR/IR780@SMEDDS in 4T1 cells increased over time and further increased with NIR laser irradiation.
Int J Nanomedicine. 2019 May 7;14:3311-3330.
Lewis Lung Carcinoma cells
10, 20, 50, 100 µM
24 and 48 h
To evaluate the effect of curcumin on tumor cell proliferation, results showed that curcumin significantly reduced tumor cell proliferation
Br J Cancer. 2012 Sep 25;107(7):1083-92.
BZR human lung epithelial tumour cells
10, 20, 50 µM
48 h
To evaluate the effect of curcumin on tumor cell proliferation, results showed that curcumin significantly reduced tumor cell proliferation
Br J Cancer. 2012 Sep 25;107(7):1083-92.
IEC-6 cells
17.4 µg/ml
24 h
To evaluate the cytotoxicity of Curcumin on IEC-6 cells, the results showed that SP@Curcumin had significantly lower cytotoxicity than free Curcumin.
Sci Adv. 2021 Nov 26;7(48):eabi9265.
CT26 cells
17.4 µg/ml
4 h
To evaluate the antitumor effect of SP@Curcumin on CT26 cells, the results showed that SP@Curcumin combined with X-ray significantly enhanced the tumor cell killing effect.
Sci Adv. 2021 Nov 26;7(48):eabi9265.
Microglia
4 μM
24 h
To assess the cytotoxicity of curcumin on microglia and hUC-MSC to determine the optimal concentration.
J Neuroinflammation. 2023 Feb 24;20(1):49.
Curcumin/姜黄素 动物实验
Species
Animal Model
Administration
Dosage
Frequency
Description
References
Rats
Sprague Dawley rats
Oral
75 mg/kg
Single dose
To evaluate the oral bioavailability of CUR/IR780@SMEDDS in rats, results showed that CUR/IR780@SMEDDS significantly improved the oral absorption of curcumin and IR780, with relative bioavailability of 743.7% and 307.0%, respectively.
Int J Nanomedicine. 2019 May 7;14:3311-3330.
C57Bl/6 mice
Lung tumor model
Oral
3 mg/kg
5 days per week, until the end of the experiment
To evaluate the effect of curcumin on lung tumor growth, results showed that curcumin significantly reduced the size of lung tumors
Br J Cancer. 2012 Sep 25;107(7):1083-92.
C57BL/6 mice
Cisplatin-induced acute kidney injury model
Gavage
100 mg/kg
Once daily for 3 days
To observe the protective effect of curcumin on cisplatin-induced acute kidney injury, results showed that curcumin significantly reduced serum creatinine and BUN levels, and decreased tubular cell necrosis and inflammation.
J Cell Mol Med. 2021 Sep;25(18):8775-8788.
Balb/c mice
Colon cancer model
Oral
1.2 mg/ml
Every 3 days for 15 days
To evaluate the chemoradiotherapeutic effect of SP@Curcumin in a colon cancer model, the results showed that SP@Curcumin significantly inhibited tumor growth and improved the survival rate of mice.
Sci Adv. 2021 Nov 26;7(48):eabi9265.
Mice
MCAO model
Intraperitoneal injection
100 mg/kg
Once every 24 hours for 3 days
To evaluate the functional recovery and neuroprotective effects of combined curcumin and hUC-MSC therapy in MCAO mice.
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