Curcumin | Diferuloylmethane;Natural Yellow 3;UNIIIT942ZTH98.;NSC32982;C.I. 75300;curcumin I;Indian Saffron;Turmeric yellow | Plant Standard | Anti-inflammation | Cyclooxygenase (COX) | Cyclooxygenase (COX) Inhibitor | Histone Acetyltransferase

首页 / / / / Curcumin

姜黄素 /Curcumin {[allProObj[0].p_purity_real_show]}

货号：A147405 同义名： Diferuloylmethane;Natural Yellow 3

Curcumin (Diferuloylmethane) 是一种天然酚类化合物，是乙酰转移酶 p300/CREB 结合蛋白的特异性抑制剂，抑制组蛋白/非组蛋白的乙酰化和组蛋白乙酰转移酶依赖的染色质转录。Curcumin 对 NF-κB 和 MAPKs 有抑制作用，具有抗炎、抗氧化、抗增殖和抗血管生成等药理作用。

Curcumin 化学结构
CAS号：458-37-7

Curcumin 3D分子结构
CAS号：458-37-7

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

Curcumin 纯度/质量文件产品仅供科研

货号：A147405 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Curcumin 生物活性

靶点

p300/CBP

p300, IC50:~25 μM
HDAC
NF-κB

描述

Curcumin, a polyphenol found in turmeric (curcuma longa), has health benefits such as antioxidant, anti-inflammatory, and anticancer properties, improvement of brain function, and control of obesity and diabetes. And dietary curcumin (80 mg kg−1) administered to mice on a high-fat diet significantly lowered the fasting blood glucose levels and TNF-α concentrations, and inhibited the lowering of glucose tolerance^[3]. Moreover, cur(curcumin) inhibited hypoxia-induced HIF1α expression and tissue damage by demonstrating the improved morphology of astrocytes and remarkable reduction in vacuolation^[4].

Curcumin 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
human A549 cells		Proliferation assay	72 h	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50=17.3 μM	24280069
human Jurkat cells		Proliferation assay	72 h	Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay, IC50=4.29 μM	24280069
human KBM5 cells		Proliferation assay	72 h	Antiproliferative activity against human KBM5 cells after 72 hrs by MTT assay, IC50=3.84 μM	24280069
human MCF7 cells		Cytotoxic assay	24 h	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay, IC50=32.2 μM	26174555

Curcumin 参考文献

[1]Cao A, Li Q, et al. Curcumin induces apoptosis in human gastric carcinoma AGS cells and colon carcinoma HT-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. Apoptosis. 2013 Nov;18(11):1391-402.

[2]Gao S, Duan X, et al. Curcumin attenuates arsenic-induced hepatic injuries and oxidative stress in experimental mice through activation of Nrf2 pathway, promotion of arsenic methylation and urinary excretion. Food Chem Toxicol. 2013 Sep;59:739-47.

[3]Tsuda T . Curcumin as a functional food-derived factor: degradation products, metabolites, bioactivity, and future perspectives. Food Funct. 2018 Feb 21;9(2):705-714. doi: 10.1039/c7fo01242j. PMID: 29206254.

[4]Daverey A, Agrawal SK. Curcumin Protects against White Matter Injury through NF-κB and Nrf2 Cross Talk. J Neurotrauma. 2020 May 15;37(10):1255-1265. doi: 10.1089/neu.2019.6749. Epub 2020 Feb 5. PMID: 31914858.

Curcumin 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.57mL

2.71mL

1.36mL

27.15mL

5.43mL

2.71mL

Curcumin 技术信息

CAS号	458-37-7
分子式	C₂₁H₂₀O₆
分子量	368.38

别名	Diferuloylmethane;Natural Yellow 3;UNIIIT942ZTH98.;NSC32982;C.I. 75300;curcumin I;Indian Saffron;Turmeric yellow
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(285.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

5%DMSO+10%PEG300+5%Tween80+80%water 4 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

human A549 cells	Proliferation assay	72 h	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay, IC50=17.3 μM	24280069
human Jurkat cells	Proliferation assay	72 h	Antiproliferative activity against human Jurkat cells after 72 hrs by MTT assay, IC50=4.29 μM	24280069
human KBM5 cells	Proliferation assay	72 h	Antiproliferative activity against human KBM5 cells after 72 hrs by MTT assay, IC50=3.84 μM	24280069
human MCF7 cells	Cytotoxic assay	24 h	Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay, IC50=32.2 μM	26174555
human SKOV3 cells	Cytotoxic assay	24 h	Cytotoxicity against human SKOV3 cells after 24 hrs by MTT assay, IC50=43.63 μM	26174555
human U266 cells	Proliferation assay	72 h	Antiproliferative activity against human U266 cells after 72 hrs by MTT assay, IC50=7.57 μM	24280069

姜黄素 /Curcumin {[allProObj[0].p_purity_real_show]}

Curcumin 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Curcumin 质控信息

Curcumin 生物活性

Curcumin 细胞研究

Curcumin 参考文献

Curcumin 实验方案

Curcumin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

p300/CBP	p300, IC50:~25 μM
HDAC
NF-κB

姜黄素 /Curcumin {[allProObj[0].p_purity_real_show]}

Curcumin 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Curcumin 质控信息

Curcumin 生物活性

Curcumin 细胞研究

Curcumin 参考文献

Curcumin 实验方案

Curcumin 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Curcumin 纯度/质量文件产品仅供科研