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4-氨基水杨酸钠 二水合物 /Sodium 4-Aminosalicylate Dihydrate {[allProObj[0].p_purity_real_show]}

货号:A200669 同义名: 对氨基水杨酸钠二水合物 / 4-Aminosalicylic acid sodium salt dihydrate;Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate Dihydrate is competitive pteridine synthetase inhibitor with antituberculocis activity.

Sodium 4-Aminosalicylate Dihydrate 化学结构 CAS号:6018-19-5
Sodium 4-Aminosalicylate Dihydrate 化学结构
CAS号:6018-19-5
Sodium 4-Aminosalicylate Dihydrate 3D分子结构
CAS号:6018-19-5
Sodium 4-Aminosalicylate Dihydrate 化学结构 CAS号:6018-19-5
Sodium 4-Aminosalicylate Dihydrate 3D分子结构 CAS号:6018-19-5
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Sodium 4-Aminosalicylate Dihydrate 纯度/质量文件 产品仅供科研

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Sodium 4-Aminosalicylate Dihydrate 生物活性

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描述 Sodium 4-aminosalicylate dihydrate (4-Aminosalicylic acid sodium salt dihydrate) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis[3]. 5-Chlorosalicylic acid (5Cl) and sodium 4-aminosalicylate (4A) were the most effective ligands for synthesizing silver complexes with high levels of antibacterial activity[4]. Mimicking the host environment in terms of iron availability should be considered for in vitro susceptibility testing of mycobacteria, especially for antibiotics interfering with iron metabolism, such as 4-aminosalicylate[5].

Sodium 4-Aminosalicylate Dihydrate 参考文献

[1]Dinis TC, Maderia VM, Almeida LM. Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers. Arch Biochem Biophys. 1994 Nov 15;315(1):161-9.

[2]Dull BJ, Salata K, et al. 5-Aminosalicylate: oxidation by activated leukocytes and protection of cultured cells from oxidative damage. Biochem Pharmacol. 1987 Aug 1;36(15):2467-72.

[3]Zheng J, Rubin EJ, Bifani P, et al. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013;288(32):23447–23456

[4]Aldabaldetrecu M, Tamayo L, Alarcon R, et al. Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects. Molecules. 2018;23(7):1629.

[5]Kopinc R, Lapanje A. Antibiotic susceptibility profile of Mycobacterium avium subspecies hominissuis is altered in low-iron conditions. J Antimicrob Chemother. 2012;67(12):2903–2907

Sodium 4-Aminosalicylate Dihydrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.74mL

0.95mL

0.47mL

23.68mL

4.74mL

2.37mL

47.36mL

9.47mL

4.74mL

Sodium 4-Aminosalicylate Dihydrate 技术信息

CAS号6018-19-5
分子式C7H10NNaO5
分子量 211.148
别名 对氨基水杨酸钠二水合物 ;4-Aminosalicylic acid sodium salt dihydrate;Sodium 4-Aminosalicylate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 105 mg/mL(497.28 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(473.6 mM),配合低频超声助溶

动物实验配方
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