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货号 产品名 纯度
A529156 现货 4-O-Methyl honokiol/4--O-甲基和厚朴酚

4-O-Methyl honokiol is a natural neolignan isolated from magnolia officinalis which acts as a PPARγ agonist and inhibtis NF-κB activity. It is used for cancer and inflammation research.

98%
A466547 现货 8-Deoxygartanin

8-Deoxygartanin是从山竹果中提取的 prenylated xanthone,具有选择性抑制 BChE 的作用,IC50 为 11.8 μM,并表现出抗疟活性和抑制 NF-κB 活化的能力。

97%
A1217129 现货 TH-263

TH-263 is an inactive analog control for LIMK inhibitors TH-257, TH-255 and TH-251.

99%+
A673893 现货 Morusin/桑辛素

Morusin shows suppression of NFκB and STAT3 in many cancer cell lines including HT-29, A549, MCF-7, and MDA-MB-231. It is a flavonoid purified from the root bark of morus alba L. with antitumor activity.

99%+
A838524 现货 Deoxyelephantopin/去氧地胆草素

Deoxyelephantopin is a natural product isolated and purified from the herbs of Elephantopus scaber Linn. with hepatoprotective and antitumor activity, by inhibiting metastatic, inducing apoptosis, modulating oxidative stress , STAT3/p53/p21 signaling, MAPK pathway, PI3k/Akt/mTOR pathway, caspase cascades, and ROS .

98+%
A714436 现货 Aristolochic acid A/马兜铃酸A

Aristolochic acid A, a natural product isolated and purified from the herb of Aristolochia debilis Sieb. et Zucc. and a potent rephrotoxin, strongly induces toxic damage during ovarian maturation by inhibiting Akt phosphorylation-mediated suppression of apoptosis.

99%+
A847241 现货 Flaconitine/乙酰乌头碱

Flaconitine is an alkaloid isolated from Aconitum flavum.

98%
A242790 现货 Berbamine dihydrochloride/盐酸小檗胺

Berbamine dihydrochloride 是一种对多发性骨髓瘤具有显著疗效的NF-κB抑制剂。

98%
A271541 现货 Vanillic acid/香草酸

Vanillic acid is a flavoring agent which is also an intermediate in the production of vanillin from ferulic acid.

98%
A117016 现货 Ethyl Caffeate/咖啡酸乙酯

Ethyl caffeate shows suppressesion of NF-κB activation and its downstream inflammatory mediators. It can be found in bidens pilosa.

98%
A1543063 现货 NF-κΒ activator 1

NF-κΒ activator 1是一种 NF-κΒ 激活剂,通过激活 NF-κΒ 信号通路,增强免疫反应。它在免疫调节和抗感染研究中具有潜在应用。

99%+
A1543793 现货 NF-κΒ activator 2

NF-κB activator 2 is a potent orally active NF-κB activator with EC50 value of 1.58 μM.

99%+
A901193 现货 BMS-345541 HCl

BMS-345541 HCl是一种选择性的 IKK 催化亚基抑制剂,对 IKK-2 的 IC50 为 0.3 μM,对 IKK-1 的 IC50 为 4 μM,在 IKK 上的别构位点结合。

99%+
A341470 现货 GSK583

GSK583 is a selective inhibitor of RIP2 Kinase and IC50 value is 5 nM.

99%+
A1165846 现货 NIK SMI1/NIK SMI1 游离态

NIK SMI1 是一种有效、选择性的 NIK 抑制剂,抑制 NIK 催化的 ATP 水解生成 ADP,IC50 值为 0.23±0.17 nM。

99%+
A375644 现货 BMS-345541

BMS-345541 dose-dependently inhibits the TNF-α-stimulated phosphorylation of IκBα in THP-1 monocytic cells with an IC50 of ~4 μM.

99%+
A107593 现货 Didox/N,3,4-三羟基苯甲酰胺

Didox can prevent LPS-induced NF-KB activation and translocation of NF-kappa beta p65 subunits.

98%
A1249394 现货 IT-901

IT-901是一种口服活性 NF-κB 亚基 c-Rel 抑制剂,具有良好的生物活性,能够阻止 NF-κB 和 c-Rel 的 DNA 结合,适用于人类淋巴瘤和移植物抗宿主病 (GVHD) 的研究。

98%+
A377370 现货 TPCA-1

TPCA-1是一种强效选择性IKK-2抑制剂,IC50为17.9 nM,有效抑制STAT3磷酸化、DNA结合和转录激活。

99%+
A181851 现货 Necrostatin-1

Necrostatin-1 is an inhibitor of RIP1 and can decrease TNF-α-induced necroptosis with EC50 of 490 nM.

99%+
产品名 NF-κB 其他靶点 纯度
PDTC ammonium 98%
QNZ ++++

NF-κB, IC50: 11 nM

99%+
Sodium 4-Aminosalicylate Dihydrate 98%
Sodium Salicylate 95%
Parthenolide p53 97% HPLC
JSH-23 +

NF-κB, IC50: 7.1 μM

98%
Phenethyl caffeate 98%
Andrographolide 98+%
Curcumin Nrf2,HDAC 98%
SC75741 +++

NF-κB, EC50: 200 nM

99%+
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

p53 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
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