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烯啶虫胺 /Nitenpyram {[allProObj[0].p_purity_real_show]}

货号:A418646 同义名: 烯啶蟲胺

Nitenpyram is a nAchR agonist, used an antiparasitic drug.

Nitenpyram 化学结构 CAS号:150824-47-8
Nitenpyram 化学结构
CAS号:150824-47-8
Nitenpyram 3D分子结构
CAS号:150824-47-8
Nitenpyram 化学结构 CAS号:150824-47-8
Nitenpyram 3D分子结构 CAS号:150824-47-8
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Nitenpyram 纯度/质量文件 产品仅供科研

货号:A418646 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 AChE AChR mAChR nAChR 其他靶点 纯度
Donepezil +++

hAChE, IC50: 11.6 nM

bAChE, IC50: 8.12 nM

98%
Loganin ++

AChE, IC50: 3.95 μM

99%+
topride HCl ++

AChE, IC50: 2.04 μM

98%
Dehydroevodiamine HCl 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

99%+
Palmatine ++

AChE, IC50: 0.51 μM

98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

98%
Trospium chloride 99%
Tiotropium Bromide Monohydrate 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

98%
Hexamethonium Bromide 99%
Pancuronium dibromide 98%
Neostigmine bromide 98%
Orphenadrine citrate 98%
Oxybutynin 98%
Irsogladine PDE 98%
Pyridostigmine bromide 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

98%
Paroxetine hydrochloride 97%
Rocuronium Bromide 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

98%
Diphenmanil methylsulfate 98%
Umeclidinium bromide 95%
Otilonium bromide 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

98%
Ipratropium bromide 98%
Diphenidol HCl 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

98%
Oxybutynin chloride 99%
Pentoxyverine citrate 98%
Solifenacin 98%
Catharanthine 98%
Benzethonium chloride +++

α7 nAChRs, IC50: 122 nM

α4β2 nAChRs, IC50: 49 nM

99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Nitenpyram 生物活性

描述 Nitenpyram is a calss of neonicotinoid and an insect nicotinic acetylcholine receptor (nAChR) agonist with an IC50 of 14 nM. Nitenpyram is an oral fast-acting insecticide used to suppress sucking insects on companion animals[3]. Nitenpyram treatments reduced the cotton damage caused by A. lucorum, and nitenpyram at the rate of 4 g/kg seed showed the most favorable efficacy in suppressing A. lucorum populations throughout the cotton seedling stage[4]. Moreover, Nitenpyram provided 100% kill of all fleas on the host at the time of treatment and for up to 24 h after treatment[5].

Nitenpyram 参考文献

[1]Rust MK, Waggoner MM, et al. Efficacy and longevity of nitenpyram against adult cat fleas (Siphonaptera: Pulicidae). J Med Entomol. 2003 Sep;40(5):678-81.

[2]Dobson P, Tinembart O, et al. Efficacy of nitenpyram as a systemic flea adulticide in dogs and cats. Vet Rec. 2000 Dec 16;147(25):709-13.

[3]Vo DT, Hsu WH, Abu-Basha EA, Martin RJ. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J Vet Pharmacol Ther. 2010 Aug;33(4):315-22. doi: 10.1111/j.1365-2885.2010.01160.x. PMID: 20646191; PMCID: PMC3725634.

[4]Zhang Z, Wang Y, Zhao Y, Li B, Lin J, Zhang X, Liu F, Mu W. Nitenpyram seed treatment effectively controls against the mirid bug Apolygus lucorum in cotton seedlings. Sci Rep. 2017 Aug 17;7(1):8573. doi: 10.1038/s41598-017-09251-9. PMID: 28819325; PMCID: PMC5561033.

[5]Rust MK, Waggoner MM, Hinkle NC, Stansfield D, Barnett S. Efficacy and longevity of nitenpyram against adult cat fleas (Siphonaptera: Pulicidae). J Med Entomol. 2003 Sep;40(5):678-81. doi: 10.1603/0022-2585-40.5.678. PMID: 14596282.

Nitenpyram 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.69mL

0.74mL

0.37mL

18.47mL

3.69mL

1.85mL

36.94mL

7.39mL

3.69mL

Nitenpyram 技术信息

CAS号150824-47-8
分子式C11H15ClN4O2
分子量 270.715
别名 烯啶蟲胺
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 120 mg/mL(443.27 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(369.39 mM)

动物实验配方
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