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Nitenpyram

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Chemical Structure| 150824-47-8 同义名 : 烯啶蟲胺
CAS号 : 150824-47-8
货号 : A418646
分子式 : C11H15ClN4O2
纯度 : 97%
分子量 : 270.715
MDL号 : MFCD01631161
存储条件:

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 120 mg/mL(443.27 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(369.39 mM)

动物实验配方:
生物活性
描述 Nitenpyram is a calss of neonicotinoid and an insect nicotinic acetylcholine receptor (nAChR) agonist with an IC50 of 14 nM. Nitenpyram is an oral fast-acting insecticide used to suppress sucking insects on companion animals[3]. Nitenpyram treatments reduced the cotton damage caused by A. lucorum, and nitenpyram at the rate of 4 g/kg seed showed the most favorable efficacy in suppressing A. lucorum populations throughout the cotton seedling stage[4]. Moreover, Nitenpyram provided 100% kill of all fleas on the host at the time of treatment and for up to 24 h after treatment[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.69mL

0.74mL

0.37mL

18.47mL

3.69mL

1.85mL

36.94mL

7.39mL

3.69mL

参考文献

[1]Rust MK, Waggoner MM, et al. Efficacy and longevity of nitenpyram against adult cat fleas (Siphonaptera: Pulicidae). J Med Entomol. 2003 Sep;40(5):678-81.

[2]Dobson P, Tinembart O, et al. Efficacy of nitenpyram as a systemic flea adulticide in dogs and cats. Vet Rec. 2000 Dec 16;147(25):709-13.

[3]Vo DT, Hsu WH, Abu-Basha EA, Martin RJ. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J Vet Pharmacol Ther. 2010 Aug;33(4):315-22. doi: 10.1111/j.1365-2885.2010.01160.x. PMID: 20646191; PMCID: PMC3725634.

[4]Zhang Z, Wang Y, Zhao Y, Li B, Lin J, Zhang X, Liu F, Mu W. Nitenpyram seed treatment effectively controls against the mirid bug Apolygus lucorum in cotton seedlings. Sci Rep. 2017 Aug 17;7(1):8573. doi: 10.1038/s41598-017-09251-9. PMID: 28819325; PMCID: PMC5561033.

[5]Rust MK, Waggoner MM, Hinkle NC, Stansfield D, Barnett S. Efficacy and longevity of nitenpyram against adult cat fleas (Siphonaptera: Pulicidae). J Med Entomol. 2003 Sep;40(5):678-81. doi: 10.1603/0022-2585-40.5.678. PMID: 14596282.