迷迭香酸 /Rosmarinic acid
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货号：A796919
同义名：
Labiatenic acid;Rosemary acid
Rosmarinic acid 是一种天然多酚，抑制 MAO-A，MAO-B 和 COMT，IC50 分别为 50.1，184.6 和 26.7 μM，具有抗氧化和抗炎活性。
Rosmarinic acid 化学结构
Rosmarinic acid 3D分子结构
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Rosmarinic acid 纯度/质量文件 产品仅供科研
货号：A796919
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Rosmarinic acid 质控信息
Rosmarinic acid 生物活性
描述
Rosmarinic acid is specific inhibitor of ε-Pol. The rosmarinic acid treatment significantly decreased extracellular HBV DNA with rough estimation of EC50 of 30 μM[3] in vitro , rosmarinic acid significantly affected root morphology causing an inhibition of both total and primary root length with 71 μM and 175 μM ED50 values, respectively[4] in vivo , rosmarinic acid at a dose of 50 mg/kg induced a decrease in the total cholesterol and triglyceride concentrations[5]
Rosmarinic acid 参考文献
[1] Andrade JM, Dos Santos Passos C, et al. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45.
[2] Fernando PM, Piao MJ, et al. Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells. Biomol Ther (Seoul). 2016 Jan;24(1):75-84.
[3] Tsukamoto Y, Ikeda S, Uwai K, et al. Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. PLoS One. 2018;13(5):e0197664. Published 2018 May 21.
[4] Araniti F, Costas-Gil A, Cabeiras-Freijanes L, et al. Rosmarinic acid induces programmed cell death in Arabidopsis seedlings through reactive oxygen species and mitochondrial dysfunction. PLoS One. 2018;13(12):e0208802. Published 2018 Dec 26.
[5] Zych M, Kaczmarczyk-Sedlak I, Wojnar W, Folwarczna J. Effect of Rosmarinic Acid on the Serum Parameters of Glucose and Lipid Metabolism and Oxidative Stress in Estrogen-Deficient Rats. Nutrients. 2019;11(2):267. Published 2019 Jan 25.
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Rosmarinic acid 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.78mL
0.56mL
0.28mL
13.88mL
2.78mL
1.39mL
27.75mL
5.55mL
2.78mL
Rosmarinic acid 技术信息
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