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维库溴铵 /Vecuronium bromide {[allProObj[0].p_purity_real_show]}

货号：A233421 同义名： ORG NC 45;Vecuronium (bromide) Ambeed 开学季，买赠积分，赢豪礼

Vecuronium bromide is a competitive AchR inhibitor and binds to cholinergic receptors at neuromuscular junctions, used as an aminosteroidal neuromuscular blocking agent.

Vecuronium bromide 化学结构 CAS号：50700-72-6
Vecuronium bromide 化学结构
CAS号：50700-72-6
Vecuronium bromide 3D分子结构
CAS号：50700-72-6
Vecuronium bromide 化学结构 CAS号：50700-72-6
Vecuronium bromide 3D分子结构 CAS号：50700-72-6
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Vecuronium bromide 纯度/质量文件 产品仅供科研

货号：A233421 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		{[allProObj[0].p_purity_real_show]}
Loganin ++

AChE, IC50: 3.95 μM

 		{[allProObj[0].p_purity_real_show]}
topride HCl ++

AChE, IC50: 2.04 μM

 		{[allProObj[0].p_purity_real_show]}
Dehydroevodiamine HCl ✔ {[allProObj[0].p_purity_real_show]}
Jatrorrhizine ++

AChE, IC50: 872 nM

 		{[allProObj[0].p_purity_real_show]}
Palmatine ++

AChE, IC50: 0.51 μM

 		{[allProObj[0].p_purity_real_show]}
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		{[allProObj[0].p_purity_real_show]}
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		{[allProObj[0].p_purity_real_show]}
Trospium chloride ✔ {[allProObj[0].p_purity_real_show]}
Tiotropium Bromide Monohydrate ✔ {[allProObj[0].p_purity_real_show]}
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		{[allProObj[0].p_purity_real_show]}
Hexamethonium Bromide ✔ {[allProObj[0].p_purity_real_show]}
Pancuronium dibromide ✔ {[allProObj[0].p_purity_real_show]}
Neostigmine bromide ✔ {[allProObj[0].p_purity_real_show]}
Orphenadrine citrate ✔ {[allProObj[0].p_purity_real_show]}
Oxybutynin ✔ {[allProObj[0].p_purity_real_show]}
Irsogladine ✔ PDE {[allProObj[0].p_purity_real_show]}
Pyridostigmine bromide ✔ {[allProObj[0].p_purity_real_show]}
Rivastigmine +

AChR, IC50: 5.5 μM

 		{[allProObj[0].p_purity_real_show]}
Paroxetine hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Rocuronium Bromide ✔ {[allProObj[0].p_purity_real_show]}
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		{[allProObj[0].p_purity_real_show]}
Diphenmanil methylsulfate ✔ {[allProObj[0].p_purity_real_show]}
Umeclidinium bromide ✔ {[allProObj[0].p_purity_real_show]}
Otilonium bromide ✔ {[allProObj[0].p_purity_real_show]}
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		{[allProObj[0].p_purity_real_show]}
Ipratropium bromide ✔ {[allProObj[0].p_purity_real_show]}
Diphenidol HCl ✔ {[allProObj[0].p_purity_real_show]}
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		{[allProObj[0].p_purity_real_show]}
Aclidinium Bromide ++++

M2 mAChR, Ki: 0.1 nM

M4 mAChR, Ki: 0.21 nM

 		{[allProObj[0].p_purity_real_show]}
Oxybutynin chloride ✔ {[allProObj[0].p_purity_real_show]}
Pentoxyverine citrate ✔ {[allProObj[0].p_purity_real_show]}
Solifenacin ✔ {[allProObj[0].p_purity_real_show]}
Catharanthine ✔ {[allProObj[0].p_purity_real_show]}
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		{[allProObj[0].p_purity_real_show]}
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		{[allProObj[0].p_purity_real_show]}
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Vecuronium bromide 生物活性

描述 Vecuronium Bromide is an aminosteriodal competitive neuromuscular blocking agent. It is used in general anesthesia as it causes muscle relaxation facilitating endotracheal intubation and to aid controlled ventilation. The pH 6 was found to be suitable for determination of VEC (Vecuronium Bromide) (pka = 8.97)[3]. Vecuronium (Bromide) produced a potent inhibition on the adult muscle-type acetylcholine receptor (IC50=8.7 nM) by competitive antagonism. Furthermore, at increasing acetylcholine concentrations, there was a significant decrease in the inhibition of the acetylcholine currents produced by 10 nM vecuronium[4].

Vecuronium bromide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02727712 Coronary Heart Disease Phase 4 Unknown December 2016 China, Hunan ... 展开 >> Xiangya Hospital of Central South University Changsha, Hunan, China, 410078 收起 <<
NCT02479581 Valvular Heart Disease Phase 2 Completed - China, Hunan ... 展开 >> Xiangya Hospital of Central South University Changsha, Hunan, China, 410078 收起 <<
NCT01642147 Brain Neoplasms ... 展开 >> Surgery Hyperemia 收起 << Not Applicable Completed - China, Shanghai ... 展开 >> Huashan Hospital Shanghai, Shanghai, China, 200040 收起 <<

Vecuronium bromide 参考文献

[1]Igarashi A, Amagasa S, et al. Vecuronium directly inhibits hypoxic neurotransmission of the rat carotid body. Anesth Analg. 2002 Jan;94(1):117-22, table of contents.

[2]Kindler CH, Verotta D, et al. Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium. Anesthesiology. 2000 Mar;92(3):821-32.

[3]Abd Elrahman MK, El Houssini OM, Fahem DK, Zaazaa HE. Stability indicating liquid chromatography method for the analysis of Vecuronium bromide: study of the degradation profile. Heliyon. 2020 Mar 16;6(3):e03530. doi: 10.1016/j.heliyon.2020.e03530. PMID: 32195388; PMCID: PMC7076553.

[4]Wang H, Liang QS, Cheng LR, Li XH, Fu W, Dai WT, Li ST. Magnesium sulfate enhances non-depolarizing muscle relaxant vecuronium action at adult muscle-type nicotinic acetylcholine receptor in vitro. Acta Pharmacol Sin. 2011 Dec;32(12):1454-9. doi: 10.1038/aps.2011.117. Epub 2011 Oct 10. PMID: 21986576; PMCID: PMC4010211.

Vecuronium bromide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.57mL

0.31mL

0.16mL

7.84mL

1.57mL

0.78mL

15.68mL

3.14mL

1.57mL

Vecuronium bromide 技术信息

CAS号50700-72-6
分子式C34H57BrN2O4
分子量 637.731
别名 ORG NC 45;Vecuronium (bromide);Vecuronium bromide. Brand name Norcuron.;NC 45
运输蓝冰
存储条件

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 45 mg/mL(70.56 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(156.81 mM)
动物实验配方

Tags: Vecuronium | 50700-72-6 | ORG NC 45 | ORG NC45 | ORG NC-45 | Membrane Transporter/Ion Channel | Neuronal Signaling | nAChR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Vecuronium bromide 纯度/质量文件 | Vecuronium bromide 亚型比较 | Vecuronium bromide 生物活性 | Vecuronium bromide 临床数据 | Vecuronium bromide 参考文献 | Vecuronium bromide 实验方案 | Vecuronium bromide 技术信息

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