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/ Rubitecan

鲁比替康 /Rubitecan {[allProObj[0].p_purity_real_show]}

货号：A759395 同义名： 鲁比特康 / RFS 2000;Rubitecan

Rubitecan is an oral topoisomerase inhibitor.

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Rubitecan 化学结构 CAS号：91421-42-0
Rubitecan 化学结构
CAS号：91421-42-0
Rubitecan 3D分子结构
CAS号：91421-42-0
Rubitecan 化学结构 CAS号：91421-42-0
Rubitecan 3D分子结构 CAS号：91421-42-0
规格 价格 会员价 库存 数量
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Rubitecan 纯度/质量文件 产品仅供科研

货号：A759395 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Topo I ↓ Topo II ↓ Topo IV ↓ Topoisomerase ↓ 其他靶点 纯度
Ellagic acid ✔ 98%
β-Lapachone ✔ 99%+
(s)-10-hydroxycamptothecin ✔ 98+%
Camptothecin ++

Topo I, IC50: 0.68 μM

 		98%
Betulinic acid ++

Eukaryotic topoisomerase I, IC50: 5 μM

 		98%
Topotecan ++++

Topo I (MCF-7 Luc cells), IC50: 13 nM

Topo I (DU-145 Luc cells), IC50: 2 nM

 		98%
Irinotecan HCl Trihydrate ✔ 98%
SN-38 ✔ 98%
Levofloxacin hydrate ✔ 98%
Dexrazoxane ✔ 99%+
Ofloxacin ✔ 98+%
Enoxacin ✔ 99%+
Flumequine +

Topo II, IC50: 15 μM

 		98%
Levofloxacin ✔ 97%
Etoposide ✔ 98%
Pefloxacin mesylate dihydrate ✔ 99+%
Marbofloxacin ✔ 98+%
Voreloxin HCl ✔ 98%
Mitoxantrone dihydrochloride ✔ PKC 98%
Nalidixic acid ✔ 98%
Doxorubicin ✔ 98%
Novobiocin sodium ✔ 95%
Amonafide ✔ 99%+
Pirarubicin ✔ 98%+
Idarubicin HCl +++

Topo II (MCF-7 cells), IC50: 3.3 ng/mL

 		99%+
Genistein ✔ EGFR 98%
Teniposide ✔ 98%
Moxifloxacin ✔ 98%
Ciprofloxacin ✔ 98%
Clinafloxacin ✔ 97%
Gatifloxacin ✔ 98%
Daunorubicin HCl +++

DNA synthesis, Ki: 20 nM

 		98%
Epirubicin HCl ✔ 99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Rubitecan 生物活性

描述 Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, inducing protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells [1][2][3].
体外研究

Rubitecan inhibits U-CH1, U-CH2, and CCL4 cells with IC50s of 0.32, 0.83, and 7.7 µM, respectively [4].

Rubitecan 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01833286 Hepatocellular Carcinoma ... 展开 >> Surgery Ablation 收起 << Phase 3 Not yet recruiting July 2019 China, Guangdong ... 展开 >> Sun Yat-sen University Cancer Center Not yet recruiting Guangzhou, Guangdong, China, 510060 Contact: minshan chen, M.D.    8620-87343117 ext 8620-87343117    chminsh@mail.sysu.edu.cn    Contact: yaojun zhang, M.D.    8620-87343121    zhyaojun@mail.sysu.edu.cn    Principal Investigator: minshan chen, M.D. 收起 <<
NCT00554905 Hepatocellular Carcinoma ... 展开 >> Liver Cancer 收起 << Phase 4 Unknown June 2009 China, Guangdong ... 展开 >> Department of Hepatobilliary Surgery, Cancer Center, Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510060 Contact: Min-Shan Chen, Doctor    86-20-87343117 ext 86-20-87343117    Chminsh@mail.sysu.edu.cn    Principal Investigator: Min-Shan Chen, Doctor 收起 <<
NCT02426450 Hepatocellular Carcinoma Phase 2 Unknown April 2017 China, Guangdong ... 展开 >> Zhen-Wei Peng Guangzhou, Guangdong, China, 510080 收起 <<

Rubitecan 参考文献

[1]Burris HA 3rd, et al. Phase II trial of oral rubitecan in previously treated pancreatic cancer patients. Oncologist. 2005 Mar;10(3):183-90.

[2]Rubitecan: 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000. Drugs R D. 2004;5(5):305-11.

[3]Rubitecan

[4]Xia M, et al. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 2013 Jul;14(7):638-47.

Rubitecan 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.71mL

2.54mL

1.27mL

25.42mL

5.08mL

2.54mL

Rubitecan 技术信息

CAS号91421-42-0
分子式C20H15N3O6
分子量 393.35
别名 鲁比特康 ;RFS 2000;Rubitecan;Orathecin.;nitrocamptothecin. US brand names: Camptogen;9-nitro-CPT;Abbreviation: 9NC. 9-nitro-camptothecin;9-nitro-20(S)-Camptothecin;Partaject rubitecan;Partaject Orathecin;9-NC
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

DMSO: 60 mg/mL(152.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Rubitecan | 91421-42-0 | RFS 2000 | 9-Nitrocamptothecin | RFS2000 | RFS-2000 | Topoisomerase Inhibitor | Cell Cycle/DNA Damage | Topoisomerase | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Rubitecan 纯度/质量文件 | Rubitecan 亚型比较 | Rubitecan 生物活性 | Rubitecan 临床数据 | Rubitecan 参考文献 | Rubitecan 实验方案 | Rubitecan 技术信息

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