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Rubitecan

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Chemical Structure| 91421-42-0 同义名 : 鲁比特康 ;RFS 2000;Rubitecan;Orathecin.;nitrocamptothecin. US brand names: Camptogen;9-nitro-CPT;Abbreviation: 9NC. 9-nitro-camptothecin;9-nitro-20(S)-Camptothecin;Partaject rubitecan;Partaject Orathecin;9-NC
CAS号 : 91421-42-0
货号 : A759395
分子式 : C20H15N3O6
纯度 : 99%+
分子量 : 393.35
MDL号 : MFCD06656294
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(152.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, inducing protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells [1][2][3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01833286 Hepatocellular Carcinoma ... 展开 >> Surgery Ablation 收起 << Phase 3 Not yet recruiting July 2019 China, Guangdong ... 展开 >> Sun Yat-sen University Cancer Center Not yet recruiting Guangzhou, Guangdong, China, 510060 Contact: minshan chen, M.D.    8620-87343117 ext 8620-87343117    chminsh@mail.sysu.edu.cn    Contact: yaojun zhang, M.D.    8620-87343121    zhyaojun@mail.sysu.edu.cn    Principal Investigator: minshan chen, M.D. 收起 <<
NCT00554905 Hepatocellular Carcinoma ... 展开 >> Liver Cancer 收起 << Phase 4 Unknown June 2009 China, Guangdong ... 展开 >> Department of Hepatobilliary Surgery, Cancer Center, Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510060 Contact: Min-Shan Chen, Doctor    86-20-87343117 ext 86-20-87343117    Chminsh@mail.sysu.edu.cn    Principal Investigator: Min-Shan Chen, Doctor 收起 <<
NCT02426450 Hepatocellular Carcinoma Phase 2 Unknown April 2017 China, Guangdong ... 展开 >> Zhen-Wei Peng Guangzhou, Guangdong, China, 510080 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.71mL

2.54mL

1.27mL

25.42mL

5.08mL

2.54mL
参考文献

[1]Burris HA 3rd, et al. Phase II trial of oral rubitecan in previously treated pancreatic cancer patients. Oncologist. 2005 Mar;10(3):183-90.

[2]Rubitecan: 9-NC, 9-Nitro-20(S)-camptothecin, 9-nitro-camptothecin, 9-nitrocamptothecin, RFS 2000, RFS2000. Drugs R D. 2004;5(5):305-11.

[3]Rubitecan

[4]Xia M, et al. Identification of repurposed small molecule drugs for chordoma therapy. Cancer Biol Ther. 2013 Jul;14(7):638-47.