MMAF can inhibit tubulin polymerization used in ADCs, with lower cytotoxic activity than MMAE.

Topotecan is an inhibitor of topoisomerase I and the IC50 values in cancer cells are less than 6 μM.

FL118是一种口服有效的Survivin抑制剂，通过结合DDX5（p68）蛋白并诱导其去磷酸化与降解，展示了在癌症治疗中的潜力，主要用于肿瘤细胞增殖和存活机制的研究。

Exatecan mesylate is a totally synthetic analogue of the topoisomerase I-inhibitor camptothecin, which was synthesised to impart increased aqueous solubility, greater tumour efficacy, and less toxicity than camptothecin itself.

Maytansinoid DM4 is a tubulin inhibitor, inhibits the assemblyof microtubules by binding to tubulin, with a linker structure can create an antibody-drug conjugate (ADC).

MMAD, a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

Maytansinol (Ansamitocin P-0) 是从 Maytansine 衍生出的，具有阻止微管聚合和触发细胞凋亡的能力，具有抗肿瘤潜力。

(S)-10-hydroxycamptothecin is an inhibitor of DNA topoisomerase I with antitumor activity.

Auristatin F is a cytotoxic tubulin modifier with potent and selective antitumor activity, and it is MMAF analog and cytotoxin in antibody-drug conjugates.

SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

Monomethyl auristatin E（MMAE；SGD-1010）是杜氏素10的合成衍生物，通过抑制微管蛋白聚合而起到强效有丝分裂抑制剂的作用。MMAE广泛用于抗体-药物结合物（ADC）的细胞毒性成分，以治疗各种癌症。

DM1（Mertansine）是一种微管抑制剂和抗体可结合的美坦新类物质，旨在克服美坦新的全身毒性并增强肿瘤特异性递送。美坦新可以通过连接子附着到单克隆抗体上，以形成抗体-药物结合物（ADC）。

9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I.

Mc-MMAE is a protective group (maleimidocaproyl)-conjugated MMAE.

Rubitecan is an oral topoisomerase inhibitor.

Paclitaxel 是一种天然抗肿瘤药物，能稳定微管蛋白 (tubulin) 的聚合，导致有丝分裂停滞和诱导细胞凋亡 (apoptosis)，最终导致细胞死亡。Paclitaxel 还可诱导细胞自噬 (autophagy)。

MMAF-OMe is a synthetic antineoplastic agent and also used as a part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A.

TKN8718 is a hydrolyzable ADC linker.

DM1-SMe 是 IMGN901 中 Maytansinoid 的非结合形式。在一组人类肿瘤细胞系中，DM1-SMe 比母体 Maytansinoid 强效约 3-10 倍，IC50 值在 0.003 到 0.01 nM 之间