Sophoridine is naturally occuring alkaloid found in the plant Sophora flavescens, which could suppresses cell growth of human medulloblastoma through the inhibition of the FoxM1, NF‑κB and AP‑1 signaling pathway.

7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I (topoisomerase).

Topotecan HCl（SKF 104864A Hydrochloride）作为一种拓扑异构酶I抑制剂，具有强效抗肿瘤活性。

Irinotecan HCl Trihydrate是一种具有抗肿瘤活性的拓扑异构酶 I 抑制剂。

SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I.

Rubitecan is an oral topoisomerase inhibitor.

Camptothecin (CPT) 是一种生物碱，作为 DNA 拓扑异构酶 I (Topo I) 抑制剂，IC50 为 679 nM。它对结直肠癌、乳腺癌、肺癌和卵巢癌表现出强效的抗肿瘤活性，并通过改变人类癌细胞中的微小 RNA (miRNA) 表达模式来调节缺氧诱导因子 1α (HIF-1α) 活性。