Sophoridine is naturally occuring alkaloid found in the plant Sophora flavescens, which could suppresses cell growth of human medulloblastoma through the inhibition of the FoxM1, NF‑κB and AP‑1 signaling pathway.

Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells.

7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I (topoisomerase).

Epirubicin HCl, a L-arabino derivative of doxorubicin, can inhibit topoisomerase and used as antineoplastic agent.

Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 = 60.3 μM).

Irinotecan HCl Trihydrate是一种具有抗肿瘤活性的拓扑异构酶 I 抑制剂。

SN-38 is an active metabolite of CPT-11 that inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks.

9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I.

Rubitecan is an oral topoisomerase inhibitor.

Doxorubicin HCl 是一种有效的 DNA 拓扑异构酶 I 和 II 抑制剂，IC50 分别为 0.8 μM 和 2.67 μM。Doxorubicin HCl 具有细胞毒性和诱导凋亡 (apoptosis) 和自噬的作用，是一种广泛应用于癌症治疗的化疗药物。

Camptothecin (CPT) 是一种生物碱，作为 DNA 拓扑异构酶 I (Topo I) 抑制剂，IC50 为 679 nM。它对结直肠癌、乳腺癌、肺癌和卵巢癌表现出强效的抗肿瘤活性，并通过改变人类癌细胞中的微小 RNA (miRNA) 表达模式来调节缺氧诱导因子 1α (HIF-1α) 活性。