Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
药物研究 囊泡
/
小分子阳性药
神经信号通路 外泌体
/
AChR
神经递质
/ Rivastigmine tartrate

酒石酸卡巴拉汀 /Rivastigmine tartrate {[allProObj[0].p_purity_real_show]}

货号：A193069 同义名： L-酒石酸卡巴拉汀 / SDZ-ENA 713;ENA 713 Ambeed 开学季，买赠积分，赢豪礼

Rivastigmine tartrate is an AchR inhibitor use for treatment of mild to moderate Alzheimer's disease and Parkinson's disease with elimination half-life of ‎1.5 hours.

Rivastigmine tartrate 化学结构 CAS号：129101-54-8
Rivastigmine tartrate 化学结构
CAS号：129101-54-8
Rivastigmine tartrate 3D分子结构
CAS号：129101-54-8
Rivastigmine tartrate 化学结构 CAS号：129101-54-8
Rivastigmine tartrate 3D分子结构 CAS号：129101-54-8
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Rivastigmine tartrate 纯度/质量文件 产品仅供科研

货号：A193069 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• JACS Au, 2024. Ambeed. [ A148168 ]
• JMC, 2024. Ambeed. [ A187643 ]
• JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]
• Biomacromolecules, 2024. Ambeed. [ A110759 ]
• Biomacromolecules, 2024. Ambeed. [ A203543 ]
更多 >
产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		{[allProObj[0].p_purity_real_show]}
Loganin ++

AChE, IC50: 3.95 μM

 		{[allProObj[0].p_purity_real_show]}
topride HCl ++

AChE, IC50: 2.04 μM

 		{[allProObj[0].p_purity_real_show]}
Dehydroevodiamine HCl ✔ {[allProObj[0].p_purity_real_show]}
Jatrorrhizine ++

AChE, IC50: 872 nM

 		{[allProObj[0].p_purity_real_show]}
Palmatine ++

AChE, IC50: 0.51 μM

 		{[allProObj[0].p_purity_real_show]}
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		{[allProObj[0].p_purity_real_show]}
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		{[allProObj[0].p_purity_real_show]}
Trospium chloride ✔ {[allProObj[0].p_purity_real_show]}
Tiotropium Bromide Monohydrate ✔ {[allProObj[0].p_purity_real_show]}
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		{[allProObj[0].p_purity_real_show]}
Hexamethonium Bromide ✔ {[allProObj[0].p_purity_real_show]}
Pancuronium dibromide ✔ {[allProObj[0].p_purity_real_show]}
Neostigmine bromide ✔ {[allProObj[0].p_purity_real_show]}
Orphenadrine citrate ✔ {[allProObj[0].p_purity_real_show]}
Oxybutynin ✔ {[allProObj[0].p_purity_real_show]}
Irsogladine ✔ PDE {[allProObj[0].p_purity_real_show]}
Pyridostigmine bromide ✔ {[allProObj[0].p_purity_real_show]}
Rivastigmine +

AChR, IC50: 5.5 μM

 		{[allProObj[0].p_purity_real_show]}
Paroxetine hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Rocuronium Bromide ✔ {[allProObj[0].p_purity_real_show]}
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		{[allProObj[0].p_purity_real_show]}
Diphenmanil methylsulfate ✔ {[allProObj[0].p_purity_real_show]}
Umeclidinium bromide ✔ {[allProObj[0].p_purity_real_show]}
Otilonium bromide ✔ {[allProObj[0].p_purity_real_show]}
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		{[allProObj[0].p_purity_real_show]}
Ipratropium bromide ✔ {[allProObj[0].p_purity_real_show]}
Diphenidol HCl ✔ {[allProObj[0].p_purity_real_show]}
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		{[allProObj[0].p_purity_real_show]}
Aclidinium Bromide ++++

M2 mAChR, Ki: 0.1 nM

M4 mAChR, Ki: 0.21 nM

 		{[allProObj[0].p_purity_real_show]}
Oxybutynin chloride ✔ {[allProObj[0].p_purity_real_show]}
Pentoxyverine citrate ✔ {[allProObj[0].p_purity_real_show]}
Solifenacin ✔ {[allProObj[0].p_purity_real_show]}
Catharanthine ✔ {[allProObj[0].p_purity_real_show]}
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		{[allProObj[0].p_purity_real_show]}
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		{[allProObj[0].p_purity_real_show]}
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Rivastigmine tartrate 生物活性

描述 Rivastigmine tartrate, a cholinesterase inhibitor (IC50= 5.5 μM), inhibits both butyrylcholinesterase (BuChE) and acetylcholinesterase (AChE). Rivastigmine (0.6 mg/kg intraperitoneally [i.p.]) inhibited AChE and BuChE by 40% and 25%, respectively[3]. Both preclinical studies and studies in human volunteers have shown that rivastigmine induces substantially greater inhibition of AChE in the central nervous system compartment than in the periphery[4]. Moreover, Rivastigmine can modify the levels of several shedding proteins and directs APP processing toward the non-amyloidogenic pathway for Alzheimer's disease[5].

Rivastigmine tartrate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00291421 - Completed - -
NCT01401582 Dementia Not Applicable Active, not recruiting March 2018 Germany ... 展开 >> Institute for Community Medicine Greifswald, Mecklenburg- Western Pommerania, Germany, 17489 收起 <<
NCT01401582 - Active, not recruiting - -

Rivastigmine tartrate 参考文献

[1]Nieto RA, Deardorff WJ, Grossberg GT. Efficacy of rivastigmine tartrate, transdermal system, in Alzheimer's disease. Expert Opin Pharmacother. 2016;17(6):861-70.

[2]Han HJ, Lee JJ, et al. Efficacy and safety of switching from oral cholinesterase inhibitors to the rivastigmine transdermal patch in patients with probable Alzheimer's disease. J Clin Neurol. 2011 Sep;7(3):137-42.

[3]Kandiah N, Pai MC, Senanarong V, Looi I, Ampil E, Park KW, Karanam AK, Christopher S. Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson's disease dementia. Clin Interv Aging. 2017 Apr 18;12:697-707. doi: 10.2147/CIA.S129145. PMID: 28458525; PMCID: PMC5402908.

[4]Polinsky RJ. Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Clin Ther. 1998 Jul-Aug;20(4):634-47. doi: 10.1016/s0149-2918(98)80127-6. PMID: 9737824.

[5]Ray B, Maloney B, Sambamurti K, Karnati HK, Nelson PT, Greig NH, Lahiri DK. Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease. Transl Psychiatry. 2020 Feb 3;10(1):47. doi: 10.1038/s41398-020-0709-x. Erratum in: Transl Psychiatry. 2020 Mar 2;10(1):81. PMID: 32066688; PMCID: PMC7026402.

Rivastigmine tartrate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.49mL

2.50mL

1.25mL

24.97mL

4.99mL

2.50mL

Rivastigmine tartrate 技术信息

CAS号129101-54-8
分子式C18H28N2O8
分子量 400.423
别名 L-酒石酸卡巴拉汀 ;SDZ-ENA 713;ENA 713;Exelon;Rivastigmine (tartrate)
运输蓝冰
存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

H2O: 50 mg/mL(124.87 mM)，配合低频超声助溶
动物实验配方

Tags: Rivastigmine | 129101-54-8 | ENA 713 | SDZ-ENA 713 | ENA713 | ENA-713 | Cholinesterase Inhibitor | Neuronal Signaling | Cholinesterase (ChE) | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Rivastigmine tartrate 纯度/质量文件 | Rivastigmine tartrate 亚型比较 | Rivastigmine tartrate 生物活性 | Rivastigmine tartrate 临床数据 | Rivastigmine tartrate 参考文献 | Rivastigmine tartrate 实验方案 | Rivastigmine tartrate 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z