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溴丙胺太林 /Propantheline bromide {[allProObj[0].p_purity_real_show]}

货号：A265499 同义名： Propantheline (bromide);Neometantyl

Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.

Propantheline bromide 化学结构 CAS号：50-34-0
Propantheline bromide 化学结构
CAS号：50-34-0
Propantheline bromide 3D分子结构
CAS号：50-34-0
Propantheline bromide 化学结构 CAS号：50-34-0
Propantheline bromide 3D分子结构 CAS号：50-34-0
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Propantheline bromide 纯度/质量文件 产品仅供科研

货号：A265499 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 98%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine hydrochloride ✔ 97%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 98%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		98%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Propantheline bromide 生物活性

描述 Propantheline bromide (PB) is a hydrolysable anti-cholinergic drug[3]. In addition, propantheline bromide's effectiveness is more than would be expected by prevention of cardioinhibition in neurocardiogenic syncope and would support a role for direct cholinergic control of vascular tone[4]. Vagal suppression was achieved in rats by administering 20 mg/kg propantheline i.p. 2 h and 1 h before gastric gavage of 20 mg/kg ibuprofen as small crushed pieces of a regular release and a fast-dissolving ibuprofen caplets[5]. Propantheline bromide at doses of 0.03--0.3 mg/kg inhibited basal and pentagastrin stimulated gastric secretion, but had no effect on histamine stimulation[6]. Subcutaneously administered propantheline bromide (30 mg/kg) or cimetidine (100 mg/kg) had no effect on gastric lesion and PD reduction caused by hemorrhagic shock[7].

Propantheline bromide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01010048 Urinary Calculus Phase 4 Unknown December 2010 China, Chongqing ... 展开 >> The First Affiliated Hospital, ChongQing medical University Recruiting ChongQing, Chongqing, China, 400016 Contact: Yunfeng He, Doctor    86-23-89011121       Contact: Xiaohou Wu, Doctor    86-23-89011122 收起 <<
NCT01640002 Overactive Bladder Associated ... 展开 >>With HTLV-1 收起 << Phase 1 Unknown April 2013 Brazil ... 展开 >> Service of Imunology - Universitary Hospital Prof. Edgard Santos Recruiting Salvador, Bahia, Brazil, 40110-070 Contact: José Abraão Carneiro Neto    557132838392    abraao.neto@gmail.com    Contact: Edgard Marcelino Carvalho Filho       imuno@ufba.br    Principal Investigator: Edgard Marcelino Carvalho Filho 收起 <<

Propantheline bromide 参考文献

[1]Baraldi C, Freguglia G, et al. Raman and SERS spectra of propantheline bromide. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Feb 15;103:1-10.

[2]Yu JC, Sung RJ. Clinical efficacy of propantheline bromide in neurocardiogenic syncope: pharmacodynamic implications. Cardiovasc Drugs Ther. 1997 Jan;10(6):687-92.

[3]Abd El-Rahman MK, Zaazaa HE, Badr ElDin N, Moustafa AA. Novel strategy for online monitoring of the degradation kinetics of propantheline bromide via a calixarene-based ion-selective electrode. Talanta. 2015 Jan;132:52-8

[4]Yu JC, Sung RJ. Clinical efficacy of propantheline bromide in neurocardiogenic syncope: pharmacodynamic implications. Cardiovasc Drugs Ther. 1997 Jan;10(6):687-92

[5]Jamali F, Aghazadeh-Habashi A. Rapidly dissolving formulations for quick absorption during pain episodes: ibuprofen. Int J Clin Pharmacol Ther. 2008 Feb;46(2):55-63

[6]Dajani EZ, Callison DA, Bianchi RG. Gastric antisecretory effects of propantheline bromide and metiamide in rhesus monkeys. Arch Int Pharmacodyn Ther. 1978 Jul;234(1):107-17

[7]Takeuchi K, Ohno T, Okabe S. Variations of gastric transmucosal potential difference and lesion formation during hemorrhagic shock in the rat. Gastroenterology. 1986 Nov;91(5):1113-22

Propantheline bromide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.15mL

2.23mL

1.12mL

22.30mL

4.46mL

2.23mL

Propantheline bromide 技术信息

CAS号50-34-0
分子式C23H30BrNO3
分子量 448.393
别名 Propantheline (bromide);Neometantyl;SC-3171;Neopepulsan;Pro-Banthine
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 105 mg/mL(234.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(111.51 mM)，配合低频超声助溶
动物实验配方

Tags: Propantheline | 50-34-0 | mAChR | Muscarinic acetylcholine receptor | mAChR Antagonist | GPCR/G Protein | Neuronal Signaling | mAChR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Propantheline bromide 纯度/质量文件 | Propantheline bromide 亚型比较 | Propantheline bromide 生物活性 | Propantheline bromide 临床数据 | Propantheline bromide 参考文献 | Propantheline bromide 实验方案 | Propantheline bromide 技术信息

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