Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 / 抑制剂/激动剂 / 神经信号通路 / AChR / Propantheline bromide

溴丙胺太林 /Propantheline bromide {[allProObj[0].p_purity_real_show]}

货号：A265499 同义名： Propantheline (bromide);Neometantyl Ambeed 开学季，买赠积分，赢豪礼

Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.

Propantheline bromide 化学结构 CAS号：50-34-0
Propantheline bromide 化学结构
CAS号：50-34-0
Propantheline bromide 3D分子结构
CAS号：50-34-0
Propantheline bromide 化学结构 CAS号：50-34-0
Propantheline bromide 3D分子结构 CAS号：50-34-0
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Propantheline bromide 纯度/质量文件 产品仅供科研

货号：A265499 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• JACS Au, 2024. Ambeed. [ A148168 ]
• JMC, 2024. Ambeed. [ A187643 ]
• JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]
• Biomacromolecules, 2024. Ambeed. [ A110759 ]
• Biomacromolecules, 2024. Ambeed. [ A203543 ]
更多 >
产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		{[allProObj[0].p_purity_real_show]}
Loganin ++

AChE, IC50: 3.95 μM

 		{[allProObj[0].p_purity_real_show]}
topride HCl ++

AChE, IC50: 2.04 μM

 		{[allProObj[0].p_purity_real_show]}
Dehydroevodiamine HCl ✔ {[allProObj[0].p_purity_real_show]}
Jatrorrhizine ++

AChE, IC50: 872 nM

 		{[allProObj[0].p_purity_real_show]}
Palmatine ++

AChE, IC50: 0.51 μM

 		{[allProObj[0].p_purity_real_show]}
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		{[allProObj[0].p_purity_real_show]}
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		{[allProObj[0].p_purity_real_show]}
Trospium chloride ✔ {[allProObj[0].p_purity_real_show]}
Tiotropium Bromide Monohydrate ✔ {[allProObj[0].p_purity_real_show]}
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		{[allProObj[0].p_purity_real_show]}
Hexamethonium Bromide ✔ {[allProObj[0].p_purity_real_show]}
Pancuronium dibromide ✔ {[allProObj[0].p_purity_real_show]}
Neostigmine bromide ✔ {[allProObj[0].p_purity_real_show]}
Orphenadrine citrate ✔ {[allProObj[0].p_purity_real_show]}
Oxybutynin ✔ {[allProObj[0].p_purity_real_show]}
Irsogladine ✔ PDE {[allProObj[0].p_purity_real_show]}
Pyridostigmine bromide ✔ {[allProObj[0].p_purity_real_show]}
Rivastigmine +

AChR, IC50: 5.5 μM

 		{[allProObj[0].p_purity_real_show]}
Paroxetine hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Rocuronium Bromide ✔ {[allProObj[0].p_purity_real_show]}
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		{[allProObj[0].p_purity_real_show]}
Diphenmanil methylsulfate ✔ {[allProObj[0].p_purity_real_show]}
Umeclidinium bromide ✔ {[allProObj[0].p_purity_real_show]}
Otilonium bromide ✔ {[allProObj[0].p_purity_real_show]}
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		{[allProObj[0].p_purity_real_show]}
Ipratropium bromide ✔ {[allProObj[0].p_purity_real_show]}
Diphenidol HCl ✔ {[allProObj[0].p_purity_real_show]}
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		{[allProObj[0].p_purity_real_show]}
Aclidinium Bromide ++++

M2 mAChR, Ki: 0.1 nM

M4 mAChR, Ki: 0.21 nM

 		{[allProObj[0].p_purity_real_show]}
Oxybutynin chloride ✔ {[allProObj[0].p_purity_real_show]}
Pentoxyverine citrate ✔ {[allProObj[0].p_purity_real_show]}
Solifenacin ✔ {[allProObj[0].p_purity_real_show]}
Catharanthine ✔ {[allProObj[0].p_purity_real_show]}
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		{[allProObj[0].p_purity_real_show]}
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		{[allProObj[0].p_purity_real_show]}
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Propantheline bromide 生物活性

描述 Propantheline bromide (PB) is a hydrolysable anti-cholinergic drug[3]. In addition, propantheline bromide's effectiveness is more than would be expected by prevention of cardioinhibition in neurocardiogenic syncope and would support a role for direct cholinergic control of vascular tone[4]. Vagal suppression was achieved in rats by administering 20 mg/kg propantheline i.p. 2 h and 1 h before gastric gavage of 20 mg/kg ibuprofen as small crushed pieces of a regular release and a fast-dissolving ibuprofen caplets[5]. Propantheline bromide at doses of 0.03--0.3 mg/kg inhibited basal and pentagastrin stimulated gastric secretion, but had no effect on histamine stimulation[6]. Subcutaneously administered propantheline bromide (30 mg/kg) or cimetidine (100 mg/kg) had no effect on gastric lesion and PD reduction caused by hemorrhagic shock[7].

Propantheline bromide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01010048 Urinary Calculus Phase 4 Unknown December 2010 China, Chongqing ... 展开 >> The First Affiliated Hospital, ChongQing medical University Recruiting ChongQing, Chongqing, China, 400016 Contact: Yunfeng He, Doctor    86-23-89011121       Contact: Xiaohou Wu, Doctor    86-23-89011122 收起 <<
NCT01640002 Overactive Bladder Associated ... 展开 >>With HTLV-1 收起 << Phase 1 Unknown April 2013 Brazil ... 展开 >> Service of Imunology - Universitary Hospital Prof. Edgard Santos Recruiting Salvador, Bahia, Brazil, 40110-070 Contact: José Abraão Carneiro Neto    557132838392    abraao.neto@gmail.com    Contact: Edgard Marcelino Carvalho Filho       imuno@ufba.br    Principal Investigator: Edgard Marcelino Carvalho Filho 收起 <<

Propantheline bromide 参考文献

[1]Baraldi C, Freguglia G, et al. Raman and SERS spectra of propantheline bromide. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Feb 15;103:1-10.

[2]Yu JC, Sung RJ. Clinical efficacy of propantheline bromide in neurocardiogenic syncope: pharmacodynamic implications. Cardiovasc Drugs Ther. 1997 Jan;10(6):687-92.

[3]Abd El-Rahman MK, Zaazaa HE, Badr ElDin N, Moustafa AA. Novel strategy for online monitoring of the degradation kinetics of propantheline bromide via a calixarene-based ion-selective electrode. Talanta. 2015 Jan;132:52-8

[4]Yu JC, Sung RJ. Clinical efficacy of propantheline bromide in neurocardiogenic syncope: pharmacodynamic implications. Cardiovasc Drugs Ther. 1997 Jan;10(6):687-92

[5]Jamali F, Aghazadeh-Habashi A. Rapidly dissolving formulations for quick absorption during pain episodes: ibuprofen. Int J Clin Pharmacol Ther. 2008 Feb;46(2):55-63

[6]Dajani EZ, Callison DA, Bianchi RG. Gastric antisecretory effects of propantheline bromide and metiamide in rhesus monkeys. Arch Int Pharmacodyn Ther. 1978 Jul;234(1):107-17

[7]Takeuchi K, Ohno T, Okabe S. Variations of gastric transmucosal potential difference and lesion formation during hemorrhagic shock in the rat. Gastroenterology. 1986 Nov;91(5):1113-22

Propantheline bromide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.15mL

2.23mL

1.12mL

22.30mL

4.46mL

2.23mL

Propantheline bromide 技术信息

CAS号50-34-0
分子式C23H30BrNO3
分子量 448.393
别名 Propantheline (bromide);Neometantyl;SC-3171;Neopepulsan;Pro-Banthine
运输蓝冰
存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(234.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(111.51 mM)，配合低频超声助溶
动物实验配方

Tags: Propantheline | 50-34-0 | mAChR | Muscarinic acetylcholine receptor | mAChR Antagonist | GPCR/G Protein | Neuronal Signaling | mAChR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Propantheline bromide 纯度/质量文件 | Propantheline bromide 亚型比较 | Propantheline bromide 生物活性 | Propantheline bromide 临床数据 | Propantheline bromide 参考文献 | Propantheline bromide 实验方案 | Propantheline bromide 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z