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/ Neochlorogenic acid

新绿原酸 /Neochlorogenic acid {[allProObj[0].p_purity_real_show]}

货号：A612121 同义名： 金银花 / trans-5-O-Caffeoylquinic acid;5-Caffeoylquinic Acid Ambeed 开学季，买赠积分，赢豪礼

Neochlorogenic Acid is a naturally occuring phenolic acid commonly found in apricots with effect on inhibiting the oxidation of low-density lipoprotein.

Neochlorogenic acid 化学结构 CAS号：906-33-2
Neochlorogenic acid 化学结构
CAS号：906-33-2
Neochlorogenic acid 3D分子结构
CAS号：906-33-2
Neochlorogenic acid 化学结构 CAS号：906-33-2
Neochlorogenic acid 3D分子结构 CAS号：906-33-2
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Neochlorogenic acid 纯度/质量文件 产品仅供科研

货号：A612121 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 NF-κB ↓ 其他靶点 纯度
Pyrrolidinedithiocarbamate ammonium ✔ {[allProObj[0].p_purity_real_show]}
QNZ ++++

NF-κB, IC50: 11 nM

 		{[allProObj[0].p_purity_real_show]}
Sodium 4-Aminosalicylate Dihydrate ✔ {[allProObj[0].p_purity_real_show]}
Sodium Salicylate ✔ {[allProObj[0].p_purity_real_show]}
Parthenolide ✔ p53 {[allProObj[0].p_purity_real_show]}
JSH-23 +

NF-κB, IC50: 7.1 μM

 		{[allProObj[0].p_purity_real_show]}
Phenethyl caffeate ✔ {[allProObj[0].p_purity_real_show]}
Andrographolide ✔ {[allProObj[0].p_purity_real_show]}
Curcumin ✔ HDAC,Nrf2 {[allProObj[0].p_purity_real_show]}
SC75741 +++

NF-κB, EC50: 200 nM

 		{[allProObj[0].p_purity_real_show]}
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

 		p53 {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ {[allProObj[0].p_purity_real_show]}
Salicylic acid ✔ {[allProObj[0].p_purity_real_show]}
Phenacetin ✔ {[allProObj[0].p_purity_real_show]}
Etodolac ✔ {[allProObj[0].p_purity_real_show]}
Flunixin meglumine ✔ {[allProObj[0].p_purity_real_show]}
Ibuprofen L-lysine ✔ {[allProObj[0].p_purity_real_show]}
Nabumetone ✔ {[allProObj[0].p_purity_real_show]}
Acemetacin ✔ {[allProObj[0].p_purity_real_show]}
Diflunisal ✔ {[allProObj[0].p_purity_real_show]}
Pranoprofen ✔ {[allProObj[0].p_purity_real_show]}
Ampiroxicam ✔ {[allProObj[0].p_purity_real_show]}
Meloxicam ✔ {[allProObj[0].p_purity_real_show]}
Sulindac ✔ {[allProObj[0].p_purity_real_show]}
Ketoprofen ✔ {[allProObj[0].p_purity_real_show]}
Mefenamic Acid ✔ {[allProObj[0].p_purity_real_show]}
Bromfenac sodium ✔ {[allProObj[0].p_purity_real_show]}
Oxaprozin ✔ {[allProObj[0].p_purity_real_show]}
Aspirin ✔ {[allProObj[0].p_purity_real_show]}
Nepafenac ✔ {[allProObj[0].p_purity_real_show]}
Zaltoprofen ✔ {[allProObj[0].p_purity_real_show]}
Salicin ✔ {[allProObj[0].p_purity_real_show]}
Suprofen ✔ {[allProObj[0].p_purity_real_show]}
Xanthohumol ✔ {[allProObj[0].p_purity_real_show]}
Parecoxib ✔ {[allProObj[0].p_purity_real_show]}
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		{[allProObj[0].p_purity_real_show]}
Etoricoxib ✔ {[allProObj[0].p_purity_real_show]}
Niflumic Acid ✔ {[allProObj[0].p_purity_real_show]}
Valdecoxib ++++

COX-2, IC50: 5 nM

 		{[allProObj[0].p_purity_real_show]}
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		{[allProObj[0].p_purity_real_show]}
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		{[allProObj[0].p_purity_real_show]}
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		{[allProObj[0].p_purity_real_show]}
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		{[allProObj[0].p_purity_real_show]}
Rofecoxib ++++

COX-2, IC50: 18 nM

 		{[allProObj[0].p_purity_real_show]}
Asaraldehyde ✔ {[allProObj[0].p_purity_real_show]}
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		{[allProObj[0].p_purity_real_show]}
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		{[allProObj[0].p_purity_real_show]}
NS-398 ++

COX-2, IC50: 3.8 μM

 		{[allProObj[0].p_purity_real_show]}
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		{[allProObj[0].p_purity_real_show]}
Nimesulide +

COX-2, IC50: 26 μM

 		{[allProObj[0].p_purity_real_show]}
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		{[allProObj[0].p_purity_real_show]}
Rutaecarpine ✔ {[allProObj[0].p_purity_real_show]}
Celecoxib ++++

COX-2, IC50: 40 nM

 		{[allProObj[0].p_purity_real_show]}
Carprofen ++++

canine COX2, IC50: 30 nM

 		{[allProObj[0].p_purity_real_show]}
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Neochlorogenic acid 生物活性

描述 Neochlorogenic Acid is a naturally occuring phenolic acid commonly found in apricots with effect on inhibiting the oxidation of low-density lipoprotein. Neochlorogenic acid (NCA) shows a reduction of lipopolysaccharide (LPS)-induced NO production by suppressing iNOS and COX-2 protein expression and production of pro-inflammatory cytokines, such as TNF-α and IL-1β, in BV2 microglia cells. In addition, phosphorylated p38 MAPK and NF-κB p65 are also inhibited by Neochlorogenic acid in activated microglia. iNOS and COX-2 levels are increased in LPS-induced BV2 cells, but this increase is significantly inhibited after treatment with 50 and 100 μM Neochlorogenic acid[3]. Neochlorogenic acid exhibited an IC50 of 20 µM in human gastric carcinoma cells. After 6 weeks of neochlorogenic acid administration to mice, the average tumor volumes and growth for the untreated control group were significantly higher than the treated groups[4]. Neochlorogenic acid showed the anti-photoaging effect through ameliorating UVB-induced collagen degradation, reinforcing the skin barrier[5].

Neochlorogenic acid 参考文献

[1]Kim M, Choi SY, Lee P, Hur J. Neochlorogenic Acid Inhibits Lipopolysaccharide-Induced Activation and Pro-inflammatory Responses in BV2 Microglial Cells. Neurochem Res. 2015 Sep;40(9):1792-8.

[2]Gaivelyte K, Jakstas V, et al. Variation in the contents of neochlorogenic acid, chlorogenic acid and three quercetin glycosides in leaves and fruits of Rowan (Sorbus) species and varieties from collections in Lithuania. Nat Prod Commun. 2013 Aug;8(8):1105-10.

[3]Kim M, Choi SY, Lee P, Hur J. Neochlorogenic Acid Inhibits Lipopolysaccharide-Induced Activation and Pro-inflammatory Responses in BV2 Microglial Cells. Neurochem Res. 2015 Sep;40(9):1792-8

[4]Fang W, Ma Y, Wang J, Yang X, Gu Y, Li Y. In vitro and in vivo antitumor activity of neochlorogenic acid in human gastric carcinoma cells are complemented with ROS generation, loss of mitochondrial membrane potential and apoptosis induction. J BUON. 2019 Jan-Feb;24(1):221-226

[5]Ahn HS, Kim HJ, Na C, Jang DS, Shin YK, Lee SH. The Protective Effect of Adenocaulon himalaicum Edgew. and Its Bioactive Compound Neochlorogenic Acid against UVB-Induced Skin Damage in Human Dermal Fibroblasts and Epidermal Keratinocytes. Plants (Basel). 2021 Aug 13;10(8):1669

Neochlorogenic acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.22mL

5.64mL

2.82mL

Neochlorogenic acid 技术信息

CAS号906-33-2
分子式C16H18O9
分子量 354.31
别名 金银花 ;trans-5-O-Caffeoylquinic acid;5-Caffeoylquinic Acid;5-O-Caffeoylquinic acid;Neochlorogenate
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(296.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 2 mg/mL(5.64 mM)，配合低频超声助溶
动物实验配方

Tags: Neochlorogenic acid | trans-5-O-Caffeoylquinic acid;5-Caffeoylquinic Acid;5-O-Caffeoylquinic acid;Neochlorogenate | 金银花 | Plant Standard | TNF Receptor | Apoptosis | COX | NF-κB | IL | Lonicera | Phenylpropanane | AmBeed-信号通路专用抑制剂 | Neochlorogenic acid 纯度/质量文件 | Neochlorogenic acid 亚型比较 | Neochlorogenic acid 生物活性 | Neochlorogenic acid 参考文献 | Neochlorogenic acid 实验方案 | Neochlorogenic acid 技术信息

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