货号:A612121 同义名: 金银花 / trans-5-O-Caffeoylquinic acid;5-Caffeoylquinic Acid
Neochlorogenic Acid is a naturally occuring phenolic acid commonly found in apricots with effect on inhibiting the oxidation of low-density lipoprotein.
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产品名称 | NF-κB ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pyrrolidinedithiocarbamate ammonium | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
QNZ |
++++
NF-κB, IC50: 11 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Sodium 4-Aminosalicylate Dihydrate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Sodium Salicylate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Parthenolide | ✔ | p53 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
JSH-23 |
+
NF-κB, IC50: 7.1 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Phenethyl caffeate | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Andrographolide | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Curcumin | ✔ | HDAC,Nrf2 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
SC75741 |
+++
NF-κB, EC50: 200 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
CBL0137 HCl |
++
NF-κB, EC50: 0.47 μM |
p53 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
产品名称 | COX ↓ ↑ | COX-1 ↓ ↑ | COX-2 ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Piroxicam | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Salicylic acid | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Phenacetin | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Etodolac | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Flunixin meglumine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Ibuprofen L-lysine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nabumetone | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Acemetacin | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Diflunisal | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Pranoprofen | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Ampiroxicam | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Meloxicam | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Sulindac | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Ketoprofen | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Mefenamic Acid | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Bromfenac sodium | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Oxaprozin | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Aspirin | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Nepafenac | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Zaltoprofen | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Salicin | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Suprofen | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Xanthohumol | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Parecoxib | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Tolfenamic Acid |
+++
COX-2, IC50: 0.2 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Etoricoxib | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Niflumic Acid | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Valdecoxib |
++++
COX-2, IC50: 5 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Ibuprofen |
+
COX-1, IC50: 13 μM |
+
COX-2, IC50: 370 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Indomethacin |
++
COX1, IC50: 0.28 μM |
+
COX-2, IC50: 14 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Lornoxicam |
++++
COX-1, IC50: 5 nM |
++++
COX-2, IC50: 8 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Meclofenamic acid sodium |
++++
COX-1, IC50: 40 nM |
+++
COX-2, IC50: 50 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Rofecoxib |
++++
COX-2, IC50: 18 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Asaraldehyde | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Naproxen |
+
COX-1, IC50: 8.7 μM |
+
COX-2, IC50: 5.2 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Diclofenac Sodium Salt |
+++
COX-1, IC50: 60 nM |
+++
COX-2, IC50: 200 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
NS-398 |
++
COX-2, IC50: 3.8 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Amfenac Sodium Hydrate |
++
COX-1, IC50: 250 nM |
+++
COX-2, IC50: 150 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Nimesulide |
+
COX-2, IC50: 26 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Lumiracoxib |
++
COX-1, Ki: 3 μM |
+++
COX-2, Ki: 60 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Rutaecarpine | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Celecoxib |
++++
COX-2, IC50: 40 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Carprofen |
++++
canine COX2, IC50: 30 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Ketorolac |
++
COX-1 (human), IC50: 1.23 μM |
++
COX-2 (human), IC50: 3.50 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Neochlorogenic Acid is a naturally occuring phenolic acid commonly found in apricots with effect on inhibiting the oxidation of low-density lipoprotein. Neochlorogenic acid (NCA) shows a reduction of lipopolysaccharide (LPS)-induced NO production by suppressing iNOS and COX-2 protein expression and production of pro-inflammatory cytokines, such as TNF-α and IL-1β, in BV2 microglia cells. In addition, phosphorylated p38 MAPK and NF-κB p65 are also inhibited by Neochlorogenic acid in activated microglia. iNOS and COX-2 levels are increased in LPS-induced BV2 cells, but this increase is significantly inhibited after treatment with 50 and 100 μM Neochlorogenic acid[3]. Neochlorogenic acid exhibited an IC50 of 20 µM in human gastric carcinoma cells. After 6 weeks of neochlorogenic acid administration to mice, the average tumor volumes and growth for the untreated control group were significantly higher than the treated groups[4]. Neochlorogenic acid showed the anti-photoaging effect through ameliorating UVB-induced collagen degradation, reinforcing the skin barrier[5]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.82mL 0.56mL 0.28mL |
14.11mL 2.82mL 1.41mL |
28.22mL 5.64mL 2.82mL |
CAS号 | 906-33-2 |
分子式 | C16H18O9 |
分子量 | 354.31 |
别名 | 金银花 ;trans-5-O-Caffeoylquinic acid;5-Caffeoylquinic Acid;5-O-Caffeoylquinic acid;Neochlorogenate |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(296.35 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 2 mg/mL(5.64 mM),配合低频超声助溶 |
动物实验配方 |