Neochlorogenic Acid is a naturally occuring phenolic acid commonly found in apricots with effect on inhibiting the oxidation of low-density lipoprotein.
Neochlorogenic Acid is a naturally occuring phenolic acid commonly found in apricots with effect on inhibiting the oxidation of low-density lipoprotein. Neochlorogenic acid (NCA) shows a reduction of lipopolysaccharide (LPS)-induced NO production by suppressing iNOS and COX-2 protein expression and production of pro-inflammatory cytokines, such as TNF-α and IL-1β, in BV2 microglia cells. In addition, phosphorylated p38 MAPK and NF-κB p65 are also inhibited by Neochlorogenic acid in activated microglia. iNOS and COX-2 levels are increased in LPS-induced BV2 cells, but this increase is significantly inhibited after treatment with 50 and 100 μM Neochlorogenic acid[3]. Neochlorogenic acid exhibited an IC50 of 20 µM in human gastric carcinoma cells. After 6 weeks of neochlorogenic acid administration to mice, the average tumor volumes and growth for the untreated control group were significantly higher than the treated groups[4]. Neochlorogenic acid showed the anti-photoaging effect through ameliorating UVB-induced collagen degradation, reinforcing the skin barrier[5].
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