Nepafenac is a selective COX2 inhibitor and is prodrug of amfenac used in the treatment of pain and inflammation associated with cataract surgery.
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HazMat fee for 500 gram (Estimated)
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USD 15-60
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USD 80+
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USD 150+
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USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery. Nepafenac exhibited only weak COX-1 inhibitory activity (IC50 = 64.3 microM). In vitro, a single topical ocular dose of nepafenac (0.1%) inhibited prostaglandin synthesis in the iris/ciliary body (85 - 95%) and the retina/choroid (55%)[3]. Nepafenac administration significantly suppresses PGE2 synthesis in the retina/choroid. Topical nepafenac administration also significantly inhibits prostaglandin (PG)-mediated blood-retinal barrier breakdown and concurrent protein extravasation into the vitreous[4]. Short term perfusion (5 min) of the corneal surface with 0.1% nepafenac resulted in sustained flux of drug across the cornea for 6h. Under identical conditions only 3.3 microM of diclofenac accumulated on the corneal endothelial side compared to 16.7 microM nepafenac[5]. An intracameral concentration of up to 1% nepafenac does not adversely affect the rabbit eye. Nepafenac fails to prevent miosis but inhibits prostaglandin release during phacoemulsification surgery[6].
United States, Minnesota
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Minnesota Eye Consultants, P.A.
Bloomington, Minnesota, United States, 55431
Associated Eye Care
Stillwater, Minnesota, United States, 55082
United States, New York
Ophthalmic Consultants of Long Island
Garden City, New York, United States, 11530
United States, South Carolina
Carolina Eyecare Physicians, LLC
Mount Pleasant, South Carolina, United States, 29464 收起 <<
Brazil
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Recruiting
Santos, Sao Paulo, Brazil, 11055360
Contact: Gustavo T Grottone, MD, MBA, MSc 551381515130 gtg2001@terra.com.br
Principal Investigator: Gustavo T Grottone, MD, MBA 收起 <<
India
... 展开 >> Aravind Eye Hospital
Recruiting
Madurai, Tamil Nadu, India
Contact: S.R. Rathinam
Principal Investigator: S.R. Rathinam, FAMS, PhD
Sub-Investigator: G. Vedhanayaki, DO 收起 <<
United States, Kentucky
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Cincinnati Eye Institute-Edgewood
Recruiting
Edgewood, Kentucky, United States, 41017
Contact: Edward Holland, MD 859-331-9000 ext 4517
United States, New York
Ophthalmic Consultants of Long Island
Recruiting
Garden City, New York, United States, 11530
Contact: Eric Donnenfeld, MD 516-500-4201
United States, South Carolina
Kerry Solomon, MD
Recruiting
Mount Pleasant, South Carolina, United States, 29464
Contact: Kerry Solomon, MD 843-881-3937 收起 <<
United States, California
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Harvard Eye Associates
Laguna Hills, California, United States, 92653
United States, Kentucky
Cincinnati Eye Institute
Edgewood, Kentucky, United States, 41017 收起 <<
Malaysia
... 展开 >> Hospital Universiti Sains Malaysia
Kubang Kerian, Kelantan, Malaysia, 16150
Hospital Selayang
Batu Caves, Selangor, Malaysia, 68000 收起 <<
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