Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the prodrug of the active metabolite 6MNA. Nabumetone (50 μmol - 2 mmol) dose-dependently inhibits the proliferation of K-562 and Meg-01 cells, but shows no obvious apoptotic effect. Nabumetone potentiates the apoptotic effect of ADR (Adriamycin) in the K-562 cell line. Moreover, Nabumetone reduces Bcl-2 expression[3]. An oral dose of nabumetone (79 mg/kg) or intravenous 6MNA produced effective anti-inflammatory activity together with significant inhibition of paw exudate PGE2. An anti-inflammatory oral dose of nabumetone or intravenous 6MNA produced minimal effects on gastric 6-keto-PGF1 alpha production, with an absence of gastric damage, in contrast to indomethacin[4]. When compared with currently available NSAIDs, nabumetone may be associated with a significantly lower incidence of gastroduodenal ulcer, and that nabumetone also appears to be safer for use in elderly patients and in those with renal or hepatic impairment[5].
Korea, Republic of
... 展开 >>
Soonchunhyang University Cheonan Hospital
Recruiting
Cheonan, Chungcheongnam-do, Korea, Republic of, 31151
Contact: SaeHwan Lee, Professor
Principal Investigator: SaeHwan Lee, Professor
Soon Chun Hyang University Bucheon Hospital
Recruiting
Bucheon, Gyeonggi do, Korea, Republic of, 14584
Contact: Sang Gyune Kim, Professor 82-32-621-5079 mcnulty@schmc.ac.kr
Principal Investigator: Sang Gyune Kim
Korea University Ansan Hospital
Recruiting
Ansan, Gyeonggi-do, Korea, Republic of, 15355
Contact: Young Kul Jung, Professor
Principal Investigator: Young Kul Jung, Professor
Inha University Hospital
Recruiting
Jung-gu, Incheon, Korea, Republic of, 22332
Contact: Jin-Woo Lee, Professor
Principal Investigator: Jin-Woo Lee, Professor
Gachon University Gil Medical Center
Recruiting
Incheon, Korea, Republic of, 21565
Contact: Oh Sang Kwon, Professor
Principal Investigator: Oh Sang Kwon, Professor
Severance hospital
Recruiting
Seoul, Korea, Republic of, 03722
Contact: Jun Yong Park, Professor
Principal Investigator: Jun Yong Park, Professor
Soonchunhyang University Hospital
Recruiting
Seoul, Korea, Republic of, 04401
Contact: Jae Young Jang, Professor
Principal Investigator: Jae Young Jang, Professor
Hanyang university hospital
Recruiting
Seoul, Korea, Republic of, 04763
Contact: Dae Won Jun, Professor
Principal Investigator: Dae Won Jun, Professor
Ewha Womans University Mokdong Hospital
Recruiting
Seoul, Korea, Republic of, 07985
Contact: Tae Hun Kim, Professor
Principal Investigator: Tae Hun Kim, Professor
Wonju severance christian hospital
Recruiting
Wonju, Korea, Republic of, 26426
Contact: Moon young Kim, Professor
Principal Investigator: Moon young Kim, Professor 收起 <<
Korea, Republic of
... 展开 >>
Asan Medical Center
Seoul, Korea, Republic of
Chung-Ang University Hospital
Seoul, Korea, Republic of
Inje University Seoul Paik Hospital
Seoul, Korea, Republic of
Seoul National University Hospital
Seoul, Korea, Republic of
SMG-SNU Boramae Medical Center
Seoul, Korea, Republic of
The Catholic University of Korea, Seoul ST. Mary's Hospital
Seoul, Korea, Republic of 收起 <<
搜索
