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Mefenamic Acid
甲芬那酸 /Mefenamic Acid
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货号：A138400
同义名：
甲灭酸
/ C.I. 473;CN-35355
Mefenamic Acid is an inhibitor of COX2 with anti-inflammatory properties, it's a non-steroidal anti-inflammatory agent.
Mefenamic Acid 化学结构
Mefenamic Acid 3D分子结构
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Mefenamic Acid 纯度/质量文件 产品仅供科研
货号：A138400
标准纯度：
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Mefenamic Acid 质控信息
Mefenamic Acid 生物活性
靶点
描述
Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively[2] [3] [4] [5]
Mefenamic Acid 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT02580344
Contraception
Phase 2
Completed
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Egypt
... 展开 >> Assiut university
Assiut, Egypt, 71111 收起 <<
NCT02968823
Pain, Postoperative
... 展开 >> Surgery, Oral 收起 <<
Not Applicable
Recruiting
December 2019
Austria
... 展开 >> MUVienna
Recruiting
Vienna, Austria
Contact: Olga Plattner olga.plattner@meduniwien.ac.at 收起 <<
NCT02943655
Improve Quality of Life
... 展开 >> Heavy Menstrual Bleeding 收起 <<
Phase 3
Recruiting
February 2019
Egypt
... 展开 >> Ahmed Abbas
Recruiting
Assiut, Cairo, Egypt, 002
Contact: ahmed abbas bmr90@hotmail.com 收起 <<
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Mefenamic Acid 参考文献
[1] Pringsheim T, Davenport WJ, et al. Acute treatment and prevention of menstrually related migraine headache: evidence-based review. Neurology. 2008 Apr 22;70(17):1555-63.
[2] Gierse JK, Hauser SD, Creely DP, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995;305 ( Pt 2)(Pt 2):479-484
[3] Hashemipour MA, Mehrabizadeh Honarmand H, Falsafi F, Tahmasebi Arashlo M, Rajabalian S, Gandjalikhan Nassab SA. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016;17(3):219-225
[4] Rajesh V, Mridhulmohan M, Jayaseelan S, Sivakumar P, Ganesan V. Mefenamic Acid Attenuates Chronic Alcohol Induced Cognitive Impairment in Zebrafish: Possible Role of Cholinergic Pathway. Neurochem Res. 2018;43(7):1392-1404
[5] Aguiar GC, Queiroz-Junior CM, Sitta GL, et al. Mefenamic acid decreases inflammation but not joint lesions in experimental osteoarthritis. Int J Exp Pathol. 2016;97(6):438-446
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Mefenamic Acid 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
4.14mL
0.83mL
0.41mL
20.72mL
4.14mL
2.07mL
41.44mL
8.29mL
4.14mL
Mefenamic Acid 技术信息
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