Mefenamic Acid | 甲灭酸 | C.I. 473 | COX Inhibitor | AmBeed-信号通路专用抑制剂

首页 / / / / Mefenamic Acid

甲芬那酸 /Mefenamic Acid {[allProObj[0].p_purity_real_show]}

货号：A138400 同义名： 甲灭酸 / C.I. 473;CN-35355

Mefenamic Acid is an inhibitor of COX2 with anti-inflammatory properties, it's a non-steroidal anti-inflammatory agent.

Mefenamic Acid 化学结构
CAS号：61-68-7

Mefenamic Acid 3D分子结构
CAS号：61-68-7

规格	价格	会员价	库存	数量
{[ item.pr_size ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]}	{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}	现货	咨询	- +

购物车0 收藏询单

sales@ambeed.cn tech@ambeed.cn 400-920-2911 产品手册产品订购技术咨询
快速发货顺丰冷链运输，1-2 天到达

品质保证

技术支持

免费溶解

Mefenamic Acid 纯度/质量文件产品仅供科研

货号：A138400 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

环氧化酶亚型比较

产品名称	COX ↓ ↑	COX-1 ↓ ↑	COX-2 ↓ ↑	纯度
Piroxicam	✔			98%
Salicylic acid	✔			98%
Phenacetin	✔			98%
Etodolac	✔			99%
Flunixin meglumine	✔			98%
Ibuprofen L-lysine	✔			99%
Nabumetone	✔			98%
Acemetacin	✔			98%
Diflunisal	✔			98%
Pranoprofen	✔			98%
Ampiroxicam	✔			98%
Meloxicam	✔			98%
Sulindac	✔			98%
Ketoprofen		✔		98%
Mefenamic Acid		✔		95%
Bromfenac sodium		✔		98%
Oxaprozin		✔		99%
Aspirin		✔		99%
Nepafenac		✔		98%
Zaltoprofen		✔		99%
Salicin		✔		98%
Suprofen		✔		99%+
Xanthohumol		✔		99%
Parecoxib			✔	98%
Tolfenamic Acid			+++ COX-2, IC50: 0.2 μM	98%
Etoricoxib			✔	99%
Niflumic Acid			✔	98%
Valdecoxib			++++ COX-2, IC50: 5 nM	99+%
Ibuprofen		+ COX-1, IC50: 13 μM	+ COX-2, IC50: 370 μM	98%
Indomethacin		++ COX1, IC50: 0.28 μM	+ COX-2, IC50: 14 μM	97%
Lornoxicam		++++ COX-1, IC50: 5 nM	++++ COX-2, IC50: 8 nM	98%
Meclofenamic acid sodium		++++ COX-1, IC50: 40 nM	+++ COX-2, IC50: 50 nM	99%
Rofecoxib			++++ COX-2, IC50: 18 nM	98%
Asaraldehyde			✔	98%
Naproxen		+ COX-1, IC50: 8.7 μM	+ COX-2, IC50: 5.2 μM	98%
Diclofenac Sodium Salt		+++ COX-1, IC50: 60 nM	+++ COX-2, IC50: 200 nM	98%
NS-398			++ COX-2, IC50: 3.8 μM	98%
Amfenac Sodium Hydrate		++ COX-1, IC50: 250 nM	+++ COX-2, IC50: 150 nM	98%+
Nimesulide			+ COX-2, IC50: 26 μM	98%
Lumiracoxib		++ COX-1, Ki: 3 μM	+++ COX-2, Ki: 60 nM	98%
Rutaecarpine			✔	95%
Celecoxib			++++ COX-2, IC50: 40 nM	98%
Carprofen			++++ canine COX2, IC50: 30 nM	98%
Ketorolac		++ COX-1 (human), IC50: 1.23 μM	++ COX-2 (human), IC50: 3.50 μM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Mefenamic Acid 生物活性

靶点

COX-1

描述

Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively^[2]. Mefenamic acid exerted cytotoxic effects on KB, Saos-2, and 1321N cells, where the viability was approximately 75%. U-87MG cells were resistant to mefenamic acid^[3]. Moreover, the memory enhancing activity of mefenamic acid might be due to activation of cholinergic transmission that has protected neuroinflammatory and neurodegenerative conditions caused by alcohol^[4]. Mefenamic acid had anti-inflammatory effects but did not reduce the progression of OA (osteoarthritis) lesions, thereby indicating that it is only effective for symptomatic control of OA^[5].

Mefenamic Acid 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02580344	Contraception	Phase 2	Completed	-	Egypt ... 展开 >> Assiut university Assiut, Egypt, 71111 收起 <<
NCT02968823	Pain, Postoperative ... 展开 >> Surgery, Oral 收起 <<	Not Applicable	Recruiting	December 2019	Austria ... 展开 >> MUVienna Recruiting Vienna, Austria Contact: Olga Plattner olga.plattner@meduniwien.ac.at 收起 <<
NCT02943655	Improve Quality of Life ... 展开 >> Heavy Menstrual Bleeding 收起 <<	Phase 3	Recruiting	February 2019	Egypt ... 展开 >> Ahmed Abbas Recruiting Assiut, Cairo, Egypt, 002 Contact: ahmed abbas bmr90@hotmail.com 收起 <<

Mefenamic Acid 参考文献

[1]Pringsheim T, Davenport WJ, et al. Acute treatment and prevention of menstrually related migraine headache: evidence-based review. Neurology. 2008 Apr 22;70(17):1555-63.

[2]Gierse JK, Hauser SD, Creely DP, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995;305 ( Pt 2)(Pt 2):479-484

[3]Hashemipour MA, Mehrabizadeh Honarmand H, Falsafi F, Tahmasebi Arashlo M, Rajabalian S, Gandjalikhan Nassab SA. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016;17(3):219-225

[4]Rajesh V, Mridhulmohan M, Jayaseelan S, Sivakumar P, Ganesan V. Mefenamic Acid Attenuates Chronic Alcohol Induced Cognitive Impairment in Zebrafish: Possible Role of Cholinergic Pathway. Neurochem Res. 2018;43(7):1392-1404

[5]Aguiar GC, Queiroz-Junior CM, Sitta GL, et al. Mefenamic acid decreases inflammation but not joint lesions in experimental osteoarthritis. Int J Exp Pathol. 2016;97(6):438-446

Mefenamic Acid 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.14mL

0.83mL

0.41mL

20.72mL

4.14mL

2.07mL

41.44mL

8.29mL

4.14mL

Mefenamic Acid 技术信息

CAS号	61-68-7
分子式	C₁₅H₁₅NO₂
分子量	241.285

别名	甲灭酸 ;C.I. 473;CN-35355;Apo Mefenamic;Antigen Brand of Mefenamic Acid;Acid, Mefenaminic;Acid, Mefenamic;Mefacit;Clonmel Brand of Mefenamic Acid;Coslan;Parkemed;Ponstel;NSC 94437;CI 473
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 105 mg/mL(435.17 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02580344	Contraception	Phase 2	Completed	-	Egypt ... 展开 >> Assiut university Assiut, Egypt, 71111 收起 <<
NCT02968823	Pain, Postoperative ... 展开 >> Surgery, Oral 收起 <<	Not Applicable	Recruiting	December 2019	Austria ... 展开 >> MUVienna Recruiting Vienna, Austria Contact: Olga Plattner olga.plattner@meduniwien.ac.at 收起 <<
NCT02943655	Improve Quality of Life ... 展开 >> Heavy Menstrual Bleeding 收起 <<	Phase 3	Recruiting	February 2019	Egypt ... 展开 >> Ahmed Abbas Recruiting Assiut, Cairo, Egypt, 002 Contact: ahmed abbas bmr90@hotmail.com 收起 <<
NCT03383133	Metabolic Side Effects of Drug... 展开 >>s 收起 <<	Early Phase 1	Not yet recruiting	April 2018	-
NCT02417337	Pain Postoper... 展开 >>ative Pain Irreversible Pulpitis 收起 <<	Phase 2	Completed	-	Sudan ... 展开 >> University of Khartoum, Faculty of Dentistry, Khartoum, Sudan, 111-11 收起 <<
NCT01598012	Primary Dysmenorrhea	Phase 4	Completed	-	Thailand ... 展开 >> Gynecologic Endocrinology Unit, Department of Obstetric and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University Bangkok, Thailand, 10700 收起 <<
NCT01942122	Endometrioma ... 展开 >>Visual Analogue Pain Scale: Moderate or Severe Pain 收起 <<	Phase 2 Phase 3	Recruiting	February 2019	Indonesia ... 展开 >> Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital (Kencana) Recruiting Jakarta Pusat, Jakarta, Indonesia, 10430 Contact: Kanadi Sumapraja, SpOG(K), MD +6221 3928720 kanadisuma@yahoo.com Contact: Budi Wiweko, SpOG(K), MD +6221 39831098 wiwekobudi@yahoo.co.id Sub-Investigator: R. Muharam, SpOG(K), MD Sub-Investigator: Andon Hestiantoro, SpOG(K), MD Sub-Investigator: Budi Wiweko, SpOG(K), MD Sub-Investigator: Herbert Situmorang, SpOG(K), MD Sub-Investigator: Gita Pratama, SpOG(K), MD Sub-Investigator: Achmad K Harzif, SpOG, MD Sub-Investigator: Mila Maidarti, SpOG, MD Sub-Investigator: Vita Silvana, SpOG, MD Department of Obstetrics and Gynecology, RSUP Persahabatan Recruiting Jakarta Pusat, Jakarta, Indonesia Contact: Botefilia, SpOG (K), MD +62214891708 botefilia@yahoo.com Principal Investigator: Botefilia, SpOG (K), MD Sub-Investigator: Zakia, SpOG, MD Sub-Investigator: Devi Marischa, SpOG, MD Department of Obstetrics and Gynecology RSUP Fatmawati Recruiting Jakarta, Indonesia Contact: Agus S As'adi, SpOG (K), MD +62217501524 agus_surur_asadi@yahoo.com Principal Investigator: Agus S As'adi, SpOG (K), MD Sub-Investigator: Luky S Syahbana, SpOG (K), MD Sub-Investigator: Malvin, SpOG (K), MD 收起 <<
NCT01295294	Uterine Hemorrhage	Phase 4	Completed	-	Denmark ... 展开 >> København NV, Denmark, DK-2400 Odense C, Denmark, DK-5000 Skive, Denmark, DK-7800 Søborg, Denmark, DK-2860 Ålborg, Denmark, DK-9000 Århus C, Denmark, DK-8000 Ireland Mallow, Cork, Ireland Blackrock, Dublin, Ireland Cork, Ireland Norway Elverum, Norway, 2403 Haugesund, Norway, 5507 Trondheim, Norway, 7012 收起 <<
NCT02183025	Dysmenorrhea	Phase 2	Completed	-	-
NCT03070678	Diabetes Mellitus	Phase 1	Completed	-	France ... 展开 >> Investigational site 250001 Gières, France 收起 <<
NCT03323671	Primary Dysmenorrhea	Phase 2 Phase 3	Completed	-	Egypt ... 展开 >> Mansoura University Mansourah, Egypt, 35516 收起 <<
NCT01060696	Infertility	Not Applicable	Unknown	May 2010	Thailand ... 展开 >> Siriraj hospital Mahidol university Bangkok, Thailand, 10700 收起 <<

甲芬那酸 /Mefenamic Acid {[allProObj[0].p_purity_real_show]}

Mefenamic Acid 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Mefenamic Acid 质控信息

Mefenamic Acid 生物活性

Mefenamic Acid 临床研究

Mefenamic Acid 参考文献

Mefenamic Acid 实验方案

Mefenamic Acid 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

甲芬那酸 /Mefenamic Acid {[allProObj[0].p_purity_real_show]}

Mefenamic Acid 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Mefenamic Acid 质控信息

Mefenamic Acid 生物活性

Mefenamic Acid 临床研究

Mefenamic Acid 参考文献

Mefenamic Acid 实验方案

Mefenamic Acid 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

请登录您的专属账户

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

Mefenamic Acid 纯度/质量文件产品仅供科研