货号：A120991同义名：
氨芬酸钠一水合物
/ Amfenac Sodium Monohydrate;Amfenac (sodium salt hydrate)
Amfenac Sodium Monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.
Amfenac Sodium Monohydrate is a COX-2 (cyclooxygenase-2) inhibitor. Amfenac affected both COX-2 transfected and non-transfected uveal melanoma cells in terms of their proliferation rates as well as their suppressive effects on macrophage cytotoxic activity[3]. Treatment of UM (uveal melanoma) cell lines with amfenac prior to radiation led to a marked reduction in proliferation rates. There appears to be a radioprotective effect of amfenac on human fibroblasts[4]. 5×10-4 M Amfenac Sodium Hydrate inhibits the release of the enzyme 35.3 and 16.3% in the presence of 10-8, and 10-7 M FMLP, respectively. Addition of 10-4 M Amfenac Sodium Hydrate causes 28.3% inhibition of aggregation of polgmorphonuclear leukocgtes (PMNs) during incubation for 16 min with 10-8 M FMLP[5]. Moreover, Amfenac treatment significantly inhibited VEGF-induced tube formation and proliferation by EC. Amfenac treatment significantly reduced retinal prostanoid production and NV (neovascularization) in OIR[6].
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