Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Bromfenac Sodium is a brominated NSAID (nonsteroidal anti-inflammatory drugs) with strong in vitro anti-inflammatory potency. In rat models of acute (carrageenan paw edema) and chronic (adjuvant arthritis) inflammation, preparations of bromfenac at concentrations as low as 0.01-0.32% (0.01-0.32 mg bromfenac) produced significant anti-inflammatory activity when applied to the injected paw or to the backs of rats, and the same dose showed topical analgesic activity in the acetylcholine-induced abdominal constriction test in mice[3]. Bromfenac protects against TGF-β1-induced synthesis of fibronectin, α-SMA, and collagen III in human pterygium fibroblasts and primary human conjunctival fibroblasts at least in part by inactivating the AKT and ERK pathways[4]. Bromfenac was well tolerated when given alone or in combination with intravitreal anti-vascular endothelial growth factor agents, topical corticosteroids, or topical mast-cell stabilizers. The most common adverse event reported was ocular irritation[5].
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