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/ Meclofenamic acid sodium

甲氯芬那酸 钠盐 /Meclofenamic acid sodium {[allProObj[0].p_purity_real_show]}

货号：A267516 同义名： 甲氯灭酸钠 / Meclofenamate sodium;Meclofenamate (sodium salt)

Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.

Meclofenamic acid sodium 化学结构 CAS号：6385-02-0
Meclofenamic acid sodium 化学结构
CAS号：6385-02-0
Meclofenamic acid sodium 3D分子结构
CAS号：6385-02-0
Meclofenamic acid sodium 化学结构 CAS号：6385-02-0
Meclofenamic acid sodium 3D分子结构 CAS号：6385-02-0
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Meclofenamic acid sodium 纯度/质量文件 产品仅供科研

货号：A267516 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 99%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Rofecoxib ++++

COX-2, IC50: 18 nM

 		98%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		98%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		98%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Meclofenamic acid sodium 生物活性

靶点

  • COX-2

    COX-2, IC50:50 nM

  • COX-1

    COX-1, IC50:40 nM
描述 Meclofenamate Sodium (MS) is an nonsteroidal anti-inflammatory drugs (NSAIDs) used to reduce pain. Addition of exogenous proteasome to MS treated cells improved cell viability[2]. Single 100- and 200-mg doses of meclofenamate sodium are as safe as, and significantly more effective than, codeine 60 mg or placebo for episiotomy pain[3]. In the majority of patients (headache and craniofacial pain), the meclofenamate sodium period scored lowest or second-lowest after the follow-up period in mean pain intensity[4]. Meclofenamate sodium in the dose administered was equally effective in relieving pain and inflammation and restoring restricted function in patients with acute gout as indometacin when used in the generally recommended dose for this indication. Meclofenamate sodium, even at these high dosage levels, was better tolerated than indometacin[5]. Similar improvement in mobility of the vertebral column and spondylitic pain could be achieved with meclofenamate sodium and indometacin in patients with ankylosing spondylitis. Meclofenamate sodium offers an effective and safe alternative to indometacin in the treatment of patients with ankylosing spondylitis[6].

Meclofenamic acid sodium 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02429570 Recurrent Brain Metastases ... 展开 >> Progressive Brain Metastases 收起 << Not Applicable Active, not recruiting April 2019 United States, Florida ... 展开 >> Baptist Health South Florida Miami, Florida, United States, 33143 United States, New Jersey Memoral Sloan Kettering Cancer Center Basking Ridge, New Jersey, United States Memorial Sloan Kettering Monmouth Middletown, New Jersey, United States, 07748 United States, New York Memorial Sloan Kettering Cancer Center at Commack Commack, New York, United States, 11725 Memorial Sloan Kettering Westchester Harrison, New York, United States, 10604 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, Pennsylvania Lehigh Valley Health Network Allentown, Pennsylvania, United States, 18103 收起 <<
NCT02930005 Psychotic Disorders ... 展开 >> Schizophrenia Schizoaffective Disorder Bipolar Disorder 收起 << Phase 2 Enrolling by invitation November 4, 2017 United States, Texas ... 展开 >> Harris County Psychiatric Center Houston, Texas, United States, 77021 收起 <<

Meclofenamic acid sodium 参考文献

[1]Eleftheriou CG, Cehajic-Kapetanovic J, et al. Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin. Mol Vis. 2017 Jun 16;23:334-345.

[2]Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. J Mol Cell Cardiol. 2016;94:131-144

[3]Hebertson RM, Storey N, Turner JL. Analgesic efficacy of meclofenamate sodium in episiotomy pain. Pharmacotherapy. 1986;6(5):205-210

[4]Mongini F, Bona G, Garnero M, Gioria A. Efficacy of meclofenamate sodium versus placebo in headache and craniofacial pain. Headache. 1993;33(1):22-28

[5]Eberl R, Dunky A. Meclofenamate sodium in the treatment of acute gout. Results of a double-blind study. Arzneimittelforschung. 1983;33(4A):641-643

[6]Ebner W, Poal Ballarin JM, Boussina I. Meclofenamate sodium in the treatment of ankylosing spondylitis. Report of a European double-blind controlled multicenter study. Arzneimittelforschung.1983;33(4A):660-663

Meclofenamic acid sodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.14mL

0.63mL

0.31mL

15.72mL

3.14mL

1.57mL

31.43mL

6.29mL

3.14mL

Meclofenamic acid sodium 技术信息

CAS号6385-02-0
分子式C14H10Cl2NNaO2
分子量 318.13
别名 甲氯灭酸钠 ;Meclofenamate sodium;Meclofenamate (sodium salt);Meclofenamic Acid;CI 583
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 120 mg/mL(377.2 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(314.34 mM)，配合低频超声助溶
动物实验配方

Tags: Meclofenamic acid sodium | Meclofenamate sodium;Meclofenamate (sodium salt);Meclofenamic Acid;CI 583 | 甲氯灭酸钠 | Cyclooxygenase (COX) | Cyclooxygenase (COX) Inhibitor | COX | AmBeed-信号通路专用抑制剂 | Meclofenamic acid sodium 纯度/质量文件 | Meclofenamic acid sodium 亚型比较 | Meclofenamic acid sodium 生物活性 | Meclofenamic acid sodium 临床数据 | Meclofenamic acid sodium 参考文献 | Meclofenamic acid sodium 实验方案 | Meclofenamic acid sodium 技术信息

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