Nimesulide | R805 | COX Inhibitor | AmBeed-信号通路专用抑制剂

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尼美舒利 /Nimesulide {[allProObj[0].p_purity_real_show]}

货号：A370794 同义名： R805

Nimesulide is a COX2 selective inhibitor with IC50 of 26 μM.

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Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Nimesulide 化学结构
CAS号：51803-78-2

Nimesulide 3D分子结构
CAS号：51803-78-2

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Nimesulide 纯度/质量文件产品仅供科研

货号：A370794 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

环氧化酶亚型比较

产品名称	COX ↓ ↑	COX-1 ↓ ↑	COX-2 ↓ ↑	纯度
Piroxicam	✔			98%
Salicylic acid	✔			98%
Phenacetin	✔			98%
Etodolac	✔			99%
Flunixin meglumine	✔			98%
Ibuprofen L-lysine	✔			99%
Nabumetone	✔			98%
Acemetacin	✔			98%
Diflunisal	✔			98%
Pranoprofen	✔			98%
Ampiroxicam	✔			98%
Meloxicam	✔			98%
Sulindac	✔			98%
Ketoprofen		✔		98%
Mefenamic Acid		✔		95%
Bromfenac sodium		✔		98%
Oxaprozin		✔		99%
Aspirin		✔		99%
Nepafenac		✔		98%
Zaltoprofen		✔		99%
Salicin		✔		98%
Suprofen		✔		99%+
Xanthohumol		✔		99%
Parecoxib			✔	98%
Tolfenamic Acid			+++ COX-2, IC50: 0.2 μM	98%
Etoricoxib			✔	99%
Niflumic Acid			✔	98%
Valdecoxib			++++ COX-2, IC50: 5 nM	99+%
Ibuprofen		+ COX-1, IC50: 13 μM	+ COX-2, IC50: 370 μM	98%
Indomethacin		++ COX1, IC50: 0.28 μM	+ COX-2, IC50: 14 μM	97%
Lornoxicam		++++ COX-1, IC50: 5 nM	++++ COX-2, IC50: 8 nM	98%
Meclofenamic acid sodium		++++ COX-1, IC50: 40 nM	+++ COX-2, IC50: 50 nM	99%
Rofecoxib			++++ COX-2, IC50: 18 nM	98%
Asaraldehyde			✔	98%
Naproxen		+ COX-1, IC50: 8.7 μM	+ COX-2, IC50: 5.2 μM	98%
Diclofenac Sodium Salt		+++ COX-1, IC50: 60 nM	+++ COX-2, IC50: 200 nM	98%
NS-398			++ COX-2, IC50: 3.8 μM	98%
Amfenac Sodium Hydrate		++ COX-1, IC50: 250 nM	+++ COX-2, IC50: 150 nM	98%+
Nimesulide			+ COX-2, IC50: 26 μM	98%
Lumiracoxib		++ COX-1, Ki: 3 μM	+++ COX-2, Ki: 60 nM	98%
Rutaecarpine			✔	95%
Celecoxib			++++ COX-2, IC50: 40 nM	98%
Carprofen			++++ canine COX2, IC50: 30 nM	98%
Ketorolac		++ COX-1 (human), IC50: 1.23 μM	++ COX-2 (human), IC50: 3.50 μM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Nimesulide 生物活性

靶点

COX-2

COX-2, IC50:26 μM

描述

Nimesulide is a selective COX-2 inhibitor, with IC50s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC50 >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties^[3]. Nimesulide, but not indomethacin, reduced the fever induced by MIP-1alpha, PGF(2alpha), CRF or ET-1. Plasma TNF-alpha levels in LPS-treated rats were also reduced by nimesulide^[4]. Nimesulide (10 µM) effectively decreases VEGF in endometrium cancer cells, and shows no effect on that in normal cells. Nimesulide (10 and 50 µM) dramatically decreases MCP-1 levels in normal cell, and such an effect is also observed with 10 µM in cancer cells. In addition, Nimesulide (50 µM) potently affects IL-8 level in normal cells, but causes no changes in cancer cells^[5].

Nimesulide 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02466581	Rheumatoid Arthritis	Phase 4	Recruiting	December 2021	Sweden ... 展开 >> Karolinska Institutet Recruiting Stockholm, Sweden, 171 76 Contact: Ronald van Vollenhoven, MD, prof +46(8)51776077 ronald.van.vollenhoven@ki.se Contact: Monica Ryden Aulin, PhD +46(8)51771110 monica.ryden.aulin@ki.se 收起 <<
NCT02563756	Knee Osteoarthritis	Not Applicable	Recruiting	September 2022	Sweden ... 展开 >> Karolinska University Hospital Recruiting Stockholm, Sweden Contact: Carl Aulin, MD carl.aulin@karolinska.se Contact: Nicolas Martinez, MD +46709900089 nicolas.martinez-carranza@karolinska.se 收起 <<
NCT03104985	-		Completed	-	-

Nimesulide 参考文献

[1]Rainsford KD; Members of the Consensus Report Group on Nimesulide. Nimesulide -- a multifactorial approach to inflammation and pain: scientific and clinical consensus. Curr Med Res Opin. 2006 Jun;22(6):1161-70.

[2]Bernareggi A. Clinical pharmacokinetics of nimesulide. Clin Pharmacokinet. 1998 Oct;35(4):247-74.

[3]Vago T, Bevilacqua M, Norbiato G. Effect of nimesulide action time dependence on selectivity towards prostaglandin G/H synthase/cyclooxygenase activity. Arzneimittelforschung.1995;45(10):1096-1098

[4]Werner MF, Souza GE, Zampronio AR. Nimesulide-induced antipyresis in rats involves both cyclooxygenase-dependent and independent mechanisms. Eur J Pharmacol. 2006;543(1-3):181-189

[5]Genç S, Attar E, Gürdöl F, Kendigelen S, Bilir A, Serdaroğlu H. The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture. Clin Exp Med. 2007;7(1):6-10

Nimesulide 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.24mL

0.65mL

0.32mL

16.22mL

3.24mL

1.62mL

32.43mL

6.49mL

3.24mL

Nimesulide 技术信息

CAS号	51803-78-2
分子式	C₁₃H₁₂N₂O₅S
分子量	308.31

别名	R805
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 105 mg/mL(340.57 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02466581	Rheumatoid Arthritis	Phase 4	Recruiting	December 2021	Sweden ... 展开 >> Karolinska Institutet Recruiting Stockholm, Sweden, 171 76 Contact: Ronald van Vollenhoven, MD, prof +46(8)51776077 ronald.van.vollenhoven@ki.se Contact: Monica Ryden Aulin, PhD +46(8)51771110 monica.ryden.aulin@ki.se 收起 <<
NCT02563756	Knee Osteoarthritis	Not Applicable	Recruiting	September 2022	Sweden ... 展开 >> Karolinska University Hospital Recruiting Stockholm, Sweden Contact: Carl Aulin, MD carl.aulin@karolinska.se Contact: Nicolas Martinez, MD +46709900089 nicolas.martinez-carranza@karolinska.se 收起 <<
NCT03104985	-		Completed	-	-
NCT02575274	Peri-implantitis	Phase 2 Phase 3	Unknown	July 2016	Brazil ... 展开 >> Federal University of Minas Gerais Belo Horizonte, Minas Gerais, Brazil, 30110031 收起 <<
NCT03400462	Temporomandibular Disorder	Not Applicable	Completed	-	-
NCT03104985	Trophic Ulcers ... 展开 >> Chronic Venous Insufficiency 收起 <<	Not Applicable	Completed	-	Russian Federation ... 展开 >> Tula Municipal Clinical Hospital №2 Tula, Russian Federation, 300002 收起 <<
NCT03616574	Advanced or Metastatic Solid T... 展开 >>umors Advanced or Metastatic Colorectal Cancer (mCRC) 收起 <<	Phase 1	Not yet recruiting	June 2021	-
NCT00932542	Hemorrhoidectomy	Phase 2 Phase 3	Unknown	November 2012	Brazil ... 展开 >> Clínica Reis Neto Campinas, São Paulo, Brazil, 13010-112 收起 <<
NCT03119324	Temporomandibular Joint Disord... 展开 >>ers 收起 <<	Not Applicable	Completed	-	-
NCT01670552	Acute and Chronic Inflammation... 展开 >> Dyspepsia 收起 <<	Phase 3	Unknown	April 2017	Brazil ... 展开 >> Allegisa Recruiting Campinas, São Paulo, Brazil, 13.084-791 Contact: Pedro A. Petersen, MD +5519 3789-8610 alexandra@grupoinvestiga.com.br Contact: Alexandra F. Drumont, SC +5519 3789-8610 alexandra@grupoinvestiga.com.br 收起 <<
NCT01500577	Breast Cancer	Phase 2	Completed	-	Italy ... 展开 >> European Institute of Oncology Milan, Italy 收起 <<
NCT02922712	Knee Osteoarthritis	Phase 4	Completed	-	-
NCT01745614	Pain	Phase 1	Completed	-	-
NCT01306708	Adhesive Capsulitis	Phase 2	Completed	-	Brazil ... 展开 >> Universidade do Sul de Santa Catarina Tubarão, Santa Catarina, Brazil, 88704-900 收起 <<
NCT02229747	Pharyngitis	Phase 4	Completed	-	-
NCT01257126	Upper Respiratory Tract Infect... 展开 >>ions 收起 <<	Phase 4	Withdrawn	-	-
NCT01609205	Rheumatoid Arthritis	Phase 4	Completed	-	Sweden ... 展开 >> Linköping University Hospital Linköping, Sweden The karolinska Institute Stockholm, Sweden, 171 76 收起 <<

尼美舒利 /Nimesulide {[allProObj[0].p_purity_real_show]}

Nimesulide 纯度/质量文件产品仅供科研

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Nimesulide 生物活性

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Nimesulide 实验方案

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尼美舒利 /Nimesulide {[allProObj[0].p_purity_real_show]}

Nimesulide 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Nimesulide 质控信息

Nimesulide 生物活性

Nimesulide 临床研究

Nimesulide 参考文献

Nimesulide 实验方案

Nimesulide 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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