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/ 环氧化酶 / Flunixin meglumine

氟尼辛葡甲胺 /Flunixin meglumine {[allProObj[0].p_purity_real_show]}

货号：A101184 同义名： Flunixin (meglumine);Banamine

Flunixin meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.

Flunixin meglumine 化学结构 CAS号：42461-84-7
Flunixin meglumine 化学结构
CAS号：42461-84-7
Flunixin meglumine 3D分子结构
CAS号：42461-84-7
Flunixin meglumine 化学结构 CAS号：42461-84-7
Flunixin meglumine 3D分子结构 CAS号：42461-84-7
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Flunixin meglumine 纯度/质量文件 产品仅供科研

货号：A101184 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 99%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Rofecoxib ++++

COX-2, IC50: 18 nM

 		98%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		98%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		98%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Flunixin meglumine 生物活性

靶点

  • COX
描述 Flunixin Meglumine (FM) is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. Intravenous FM, 1.1 mg kg-1, significantly inhibited carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, < 0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h. Flunixin meglumine significantly inhibited the rise in skin temperature but had a limited effect on exudate WBC(white blood cell). Flunixin meglumine was a more potent COX inhibitor than PBZ (phenylbutazone) and was more selective for the inducible form of COX in vivo[3]. Administration of flunixin meglumine improved pregnancy rates in excitable recipient cows following embryo transfer without affecting the proportion of non-pregnant cows returning to estrus[4].

Flunixin meglumine 参考文献

[1]Bryant CE, Farnfield BA, et al. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res. 2003 Feb;64(2):211-5.

[2]Anderson KL, Smith AR, et al. Efficacy of flunixin meglumine for the treatment of endotoxin-induced bovine mastitis. Am J Vet Res. 1986 Jun;47(6):1366-72.

[3]Cheng Z, Nolan AM, McKellar QA. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998;22(4):353-366

[4]Kasimanickam RK, Hall JB, Estill CT, et al. Flunixin meglumine improves pregnancy rate in embryo recipient beef cows with an excitable temperament. Theriogenology. 2018;107:70-77

Flunixin meglumine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.17mL

2.03mL

1.02mL

20.35mL

4.07mL

2.03mL

Flunixin meglumine 技术信息

CAS号42461-84-7
分子式C21H28F3N3O7
分子量 491.458
别名 Flunixin (meglumine);Banamine;Flunixin-S;Flumeglumine;NIH 10250;Flunixin Meglumin
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 105 mg/mL(213.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(101.74 mM)，配合低频超声助溶
动物实验配方

Tags: Flunixin | 42461-84-7 | COX | Cyclooxygenase | COX Inhibitor | Immunology/Inflammation | COX | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Flunixin meglumine 纯度/质量文件 | Flunixin meglumine 亚型比较 | Flunixin meglumine 生物活性 | Flunixin meglumine 参考文献 | Flunixin meglumine 实验方案 | Flunixin meglumine 技术信息

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