Flunixin meglumine | Flunixin (meglumine) | COX Inhibitor

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氟尼辛葡甲胺 /Flunixin meglumine 98%

货号：A101184 同义名： Flunixin (meglumine);Banamine

Flunixin meglumine is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity.

Flunixin meglumine 化学结构
CAS号：42461-84-7

Flunixin meglumine 3D分子结构
CAS号：42461-84-7

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Flunixin meglumine 纯度/质量文件产品仅供科研

货号：A101184 标准纯度： 98% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

环氧化酶亚型比较

产品名称	COX ↓ ↑	COX-1 ↓ ↑	COX-2 ↓ ↑	纯度
Piroxicam	✔			98%
Salicylic acid	✔			98%
Phenacetin	✔			98%
Etodolac	✔			99%
Flunixin meglumine	✔			98%
Ibuprofen L-lysine	✔			99%
Nabumetone	✔			98%
Acemetacin	✔			98%
Diflunisal	✔			98%
Pranoprofen	✔			98%
Ampiroxicam	✔			98%
Meloxicam	✔			98%
Sulindac	✔			98%
Ketoprofen		✔		98%
Mefenamic Acid		✔		95%
Bromfenac sodium		✔		98%
Oxaprozin		✔		99%
Aspirin		✔		99%
Nepafenac		✔		98%
Zaltoprofen		✔		99%
Salicin		✔		98%
Suprofen		✔		99%+
Xanthohumol		✔		99%
Parecoxib			✔	98%
Tolfenamic Acid			+++ COX-2, IC50: 0.2 μM	98%
Etoricoxib			✔	99%
Niflumic Acid			✔	98%
Valdecoxib			++++ COX-2, IC50: 5 nM	99+%
Ibuprofen		+ COX-1, IC50: 13 μM	+ COX-2, IC50: 370 μM	98%
Indomethacin		++ COX1, IC50: 0.28 μM	+ COX-2, IC50: 14 μM	97%
Lornoxicam		++++ COX-1, IC50: 5 nM	++++ COX-2, IC50: 8 nM	98%
Meclofenamic acid sodium		++++ COX-1, IC50: 40 nM	+++ COX-2, IC50: 50 nM	99%
Rofecoxib			++++ COX-2, IC50: 18 nM	98%
Asaraldehyde			✔	98%
Naproxen		+ COX-1, IC50: 8.7 μM	+ COX-2, IC50: 5.2 μM	98%
Diclofenac Sodium Salt		+++ COX-1, IC50: 60 nM	+++ COX-2, IC50: 200 nM	98%
NS-398			++ COX-2, IC50: 3.8 μM	98%
Amfenac Sodium Hydrate		++ COX-1, IC50: 250 nM	+++ COX-2, IC50: 150 nM	98%+
Nimesulide			+ COX-2, IC50: 26 μM	98%
Lumiracoxib		++ COX-1, Ki: 3 μM	+++ COX-2, Ki: 60 nM	98%
Rutaecarpine			✔	95%
Celecoxib			++++ COX-2, IC50: 40 nM	98%
Carprofen			++++ canine COX2, IC50: 30 nM	98%
Ketorolac		++ COX-1 (human), IC50: 1.23 μM	++ COX-2 (human), IC50: 3.50 μM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Flunixin meglumine 生物活性

靶点

描述

Flunixin Meglumine (FM) is a potent inhibitor of COX used as analgesic agent with anti-inflammatory and antipyretic activity. Intravenous FM, 1.1 mg kg-1, significantly inhibited carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, < 0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h. Flunixin meglumine significantly inhibited the rise in skin temperature but had a limited effect on exudate WBC(white blood cell). Flunixin meglumine was a more potent COX inhibitor than PBZ (phenylbutazone) and was more selective for the inducible form of COX in vivo^[3]. Administration of flunixin meglumine improved pregnancy rates in excitable recipient cows following embryo transfer without affecting the proportion of non-pregnant cows returning to estrus^[4].

Flunixin meglumine 参考文献

[1]Bryant CE, Farnfield BA, et al. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am J Vet Res. 2003 Feb;64(2):211-5.

[2]Anderson KL, Smith AR, et al. Efficacy of flunixin meglumine for the treatment of endotoxin-induced bovine mastitis. Am J Vet Res. 1986 Jun;47(6):1366-72.

[3]Cheng Z, Nolan AM, McKellar QA. Measurement of cyclooxygenase inhibition in vivo: a study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation. 1998;22(4):353-366

[4]Kasimanickam RK, Hall JB, Estill CT, et al. Flunixin meglumine improves pregnancy rate in embryo recipient beef cows with an excitable temperament. Theriogenology. 2018;107:70-77

Flunixin meglumine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.03mL

0.41mL

0.20mL

10.17mL

2.03mL

1.02mL

20.35mL

4.07mL

2.03mL

Flunixin meglumine 技术信息

CAS号	42461-84-7
分子式	C₂₁H₂₈F₃N₃O₇
分子量	491.458

别名	Flunixin (meglumine);Banamine;Flunixin-S;Flumeglumine;NIH 10250;Flunixin Meglumin
运输	蓝冰

存储条件

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(213.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 50 mg/mL(101.74 mM)，配合低频超声助溶

动物实验配方

氟尼辛葡甲胺 /Flunixin meglumine 98%

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Flunixin meglumine 生物活性

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Flunixin meglumine 技术信息

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氟尼辛葡甲胺 /Flunixin meglumine 98%

Flunixin meglumine 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Flunixin meglumine 质控信息

Flunixin meglumine 生物活性

Flunixin meglumine 参考文献

Flunixin meglumine 实验方案

Flunixin meglumine 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Flunixin meglumine 纯度/质量文件产品仅供科研