酮咯酸 /Ketorolac
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货号：A147716
同义名：
RS37619
Ketorolac, a non-selective COX inhibitor with IC50s of 1.23 μM and 3.50 μM for COX1 and COX2, is a non-steroidal anti-inflammatory drug.
Ketorolac 化学结构
Ketorolac 3D分子结构
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Ketorolac 纯度/质量文件 产品仅供科研
货号：A147716
标准纯度：
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产品说明书
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Ketorolac 质控信息
Ketorolac 生物活性
靶点
COX-2
COX-2 (human), IC50:3.50 μM
COX-1
COX-1 (human), IC50:1.23 μM
描述
Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. In the animal model, both ketorolac 0.4% and bromfenac 0.09% demonstrated maximal anti-inflammatory activity in treated eyes[3] [4] [5]
Ketorolac 参考文献
[1] Berg J, Fellier H, et al. The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm Res. 1999 Jul;48(7):369-79.
[2] Jett MF, Ramesha CS, et al. Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J Pharmacol Exp Ther. 1999 Mar;288(3):1288-97.
[3] Waterbury LD, Silliman D, Jolas T. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006;22(6):1133-1140
[4] Fracon RN, Teófilo JM, Moris IC, Lamano T. Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010;18(6):630-634
[5] Hsieh YC, Liang WY, Tsai SK, Wong CS. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005;100(4):1134-1139
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Ketorolac 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.92mL
0.78mL
0.39mL
19.59mL
3.92mL
1.96mL
39.17mL
7.83mL
3.92mL
Ketorolac 技术信息
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