奥沙普秦 /Oxaprozin
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货号：A395168
同义名：
Oxaprozinum;Wy21743
Oxaprozin 是一种 COX 抑制剂，其 IC50 分别为 2.2 μM（人血小板 COX-1）和 36 μM（IL-1 刺激的人滑膜细胞 COX-2）。它是一种非甾体抗炎药（NSAID），用于缓解与骨关节炎和类风湿性关节炎相关的炎症、肿胀、僵硬和关节疼痛。
Oxaprozin 化学结构
Oxaprozin 3D分子结构
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Oxaprozin 纯度/质量文件 产品仅供科研
货号：A395168
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Oxaprozin 质控信息
Oxaprozin 生物活性
靶点
描述
Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB. Oxaprozin reversed in a dose-dependent manner immune complex-induced survival of monocytes, without affecting the apoptosis of resting cells. Other NSAIDs (Non-steroidal anti-inflammatory drugs) are ineffective. Oxaprozin-mediated inhibition of the Akt/IKK/NF-kappaB pathway contributes to its anti-inflammatory properties[3] [4]
Oxaprozin 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT03350386
Healthy
Phase 1
Completed
-
Japan
... 展开 >> P-One Clinic
Hachiōji, Tokyo, Japan, 192-0071 收起 <<
Oxaprozin 参考文献
[1] Maestrelli F, Cirri M, et al. Improvement of oxaprozin solubility and permeability by the combined use of cyclodextrin, chitosan, and bile components. Eur J Pharm Biopharm. 2011 Aug;78(3):385-93.
[2] Kean WF. Oxaprozin: kinetic and dynamic profile in the treatment of pain. Curr Med Res Opin. 2004 Aug;20(8):1275-7.
[3] Ottonello L, Bertolotto M, Montecucco F, Bianchi G, Dallegri F. Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009;157(2):294-306
[4] Montecucco F, Bertolotto M, Ottonello L, Quercioli A, Mach F, Dallegri F. Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways. J Biomed Biotechnol. 2009;2009:478785
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Oxaprozin 实验方案
计算器
摩尔计算器
总药量计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.41mL
0.68mL
0.34mL
17.05mL
3.41mL
1.70mL
34.09mL
6.82mL
3.41mL
Oxaprozin 技术信息
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