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/ Aspirin

乙酰水杨酸 /Aspirin 99%

货号：A1457229 同义名： 阿司匹林;邻乙酰水杨酸 / Acetylsalicylic Acid;ASA Ambeed 开学季，买赠积分，赢豪礼

Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an anti-inflammatory compound that inhibits Cox-1.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Aspirin 化学结构 CAS号：50-78-2
Aspirin 化学结构
CAS号：50-78-2
Aspirin 3D分子结构
CAS号：50-78-2
Aspirin 化学结构 CAS号：50-78-2
Aspirin 3D分子结构 CAS号：50-78-2
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Aspirin 纯度/质量文件 产品仅供科研

货号：A1457229 标准纯度： 99%
批次查询： 批次纯度:

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产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 99%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Rofecoxib ++++

COX-2, IC50: 18 nM

 		98%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		98%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		98%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Aspirin 生物活性

靶点

  • COX-1
描述 Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1]. Aspirin and other non-steroid anti-inflammatory drugs inhibit the activity of cyclooxygenase (COX) which leads to the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever[2]. Aspirin acetylates serine-530 of cyclooxygenase-1 (COX-1), thereby blocking thromboxane A (2) synthesis in platelets and reducing platelet aggregation. Aspirin and salicylate at therapeutic concentrations inhibit COX-2 protein expression through interference with binding of CCAAT/enhancer binding protein beta (C/EBPbeta) to its cognate site on COX-2 promoter/enhancer. Aspirin at suprapharmacological concentrations inhibits NF-kappaB-mediated gene transcription and protects tissue from injury[3]. Low-dose aspirin therapy (75-162 mg) is reasonable for patients with diabetes mellitus and a 10-year risk of cardiovascular events >10%[4]. Among those with suspected evolving MI (myocardial infarction), aspirin significantly reduces the risk of reinfarction, stroke, and vascular mortality[5].

Aspirin 细胞研究

细胞系 浓度 检测类型 检测时间 活动说明 数据源
human AGS cells 15-60 μmol/L Function assay 12 h Inhibition of Escherichia coli-stimulated IL-8 production in human AGS cells at 15 to 60 umol/L after 12 hrs by ELISA 20153183
human HCT116 cells 1 mM Function assay 6 h Inhibition of TNF-alpha-induced NF-kappaB activation in human HCT116 cells at 1 mM after 6 hrs by luciferase reporter gene assay 22154834
human MDA-MB-231 cells 100 μM Function assay 30 mins Irreversible inhibition of COX-1 in human MDA-MB-231 cells assessed as inhibition of arachidonic acid-induced PGE2 formation at 100 uM incubated for 30 mins followed by compound washout measured 30 mins post arachidonic acid challenge by radioimmunoassay 23651359
human PANC1 cells 300 μM Growth inhibition assay 48 h Growth inhibition of human PANC1 cells at 300 uM after 48 hrs by alamar blue assay 22494617

Aspirin 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02326350 Acute Respiratory Distress Syn... 展开 >>drome 收起 << Phase 2 Enrolling by invitation July 2017 -
NCT01784159 Sepsis Phase 2 Active, not recruiting January 2019 Brazil ... 展开 >> Hospital São Paulo São Paulo, Brazil, 04024002 收起 <<
NCT00178464 - Completed - -

Aspirin 参考文献

[1]Yin MJ, Yamamoto Y, et al. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature. 1998 Nov 5;396(6706):77-80.

[2]Kopp E, Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9.

[3]Mitchell JA, Akarasereenont P, Thiemermann C, Flower RJ, Vane JR. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7

[4]Vane JR, Botting RM. The mechanism of action of aspirin. Thromb Res. 2003 Jun 15;110(5-6):255-8

[5]Wu KK. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12

[6]Pignone M, Williams CD. Aspirin for primary prevention of cardiovascular disease in diabetes mellitus. Nat Rev Endocrinol. 2010 Nov;6(11):619-28

[7]Hennekens CH. Aspirin in chronic cardiovascular disease and acute myocardial infarction. Clin Cardiol. 1990 Mar;Suppl 5:V62-6; discussion V67-72

Aspirin 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.55mL

1.11mL

0.56mL

27.75mL

5.55mL

2.78mL

55.51mL

11.10mL

5.55mL

Aspirin 技术信息

CAS号50-78-2
分子式C9H8O4
分子量 180.157
别名 阿司匹林;邻乙酰水杨酸;2-乙酰氧基苯甲酸 ;Acetylsalicylic Acid;ASA;Claradin;Acetylin;NSC 406186;NSC 27223
运输蓝冰
存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 105 mg/mL(582.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Aspirin | Acetylsalicylic Acid;ASA;Claradin;Acetylin;NSC 406186;NSC 27223 | 阿司匹林;邻乙酰水杨酸;2-乙酰氧基苯甲酸 | Inflammation Model | Drug Standard | Anti-inflammation | Cyclooxygenase (COX) | Cyclooxygenase (COX) Inhibitor | COX | AmBeed-信号通路专用抑制剂 | Aspirin 纯度/质量文件 | Aspirin 亚型比较 | Aspirin 生物活性 | Aspirin 细胞研究 | Aspirin 临床数据 | Aspirin 参考文献 | Aspirin 实验方案 | Aspirin 技术信息

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