Salicin is a non-selective COX-1 and COX-2 inhibitor, it is a phenol β-glycosid isolated and purified from the peel of Salix alba L.and shows anti-inflammatory effects.
Salicin is a natural COX inhibitor. At the cellular level, salicin attenuates IL-1β-induced mitochondrial injury as revealed by its preservation on mitochondrial membrane potential (MMP). Furthermore, salicin inhibits IL-1β-induced production of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), vascular adhesion molecules such as intercellular cell adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and high-mobility group protein 1 (HMGB-1) [3]. Salicin significantly reduced cell viability, cytokines, and matrix metalloproteinases-1/-3 expression in IL-1β-induced RA-FLSs and inhibited ROS generation and p65 phosphorylation as compared with IL-1β-induced treatment. Moreover, salicin promoted Nrf2 nuclear translocation and HO-1 expression and reduced ROS production in IL-1β-induced RA-FLSs[4].
United States, North Carolina
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ASU Human Performance Laboratory, North Carolina Research Campus
Kannapolis, North Carolina, United States, 28081 收起 <<
United States, North Carolina
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ASU Human Performance Laboratory, North Carolina Research Campus
Kannapolis, North Carolina, United States, 28081 收起 <<
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