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/ 环氧化酶 / Ibuprofen L-lysine

布洛芬L-赖氨酸 /Ibuprofen L-lysine {[allProObj[0].p_purity_real_show]}

货号：A336048 同义名： 布洛芬赖氨酸盐 / Ibuprofen Lysine;(±)-Ibuprofen L-lysine

Ibuprofen lysine is a non-steroidal anti-inflammatory drug (NSAID).

Ibuprofen L-lysine 化学结构 CAS号：57469-77-9
Ibuprofen L-lysine 化学结构
CAS号：57469-77-9
Ibuprofen L-lysine 3D分子结构
CAS号：57469-77-9
Ibuprofen L-lysine 化学结构 CAS号：57469-77-9
Ibuprofen L-lysine 3D分子结构 CAS号：57469-77-9
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Ibuprofen L-lysine 纯度/质量文件 产品仅供科研

货号：A336048 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 COX ↓ COX-1 ↓ COX-2 ↓ 其他靶点 纯度
Piroxicam ✔ 98%
Salicylic acid ✔ 98%
Phenacetin ✔ 98%
Etodolac ✔ 99%
Flunixin meglumine ✔ 98%
Ibuprofen L-lysine ✔ 99%
Nabumetone ✔ 98%
Acemetacin ✔ 98%
Diflunisal ✔ 98%
Pranoprofen ✔ 98%
Ampiroxicam ✔ 98%
Meloxicam ✔ 98%
Sulindac ✔ 98%
Ketoprofen ✔ 98%
Mefenamic Acid ✔ 95%
Bromfenac sodium ✔ 98%
Oxaprozin ✔ 99%
Aspirin ✔ 99%
Nepafenac ✔ 98%
Zaltoprofen ✔ 99%
Salicin ✔ 98%
Suprofen ✔ 99%+
Xanthohumol ✔ 99%
Parecoxib ✔ 98%
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

 		98%
Etoricoxib ✔ 99%
Niflumic Acid ✔ 98%
Valdecoxib ++++

COX-2, IC50: 5 nM

 		99+%
Ibuprofen +

COX-1, IC50: 13 μM

 		+

COX-2, IC50: 370 μM

 		98%
Indomethacin ++

COX1, IC50: 0.28 μM

 		+

COX-2, IC50: 14 μM

 		97%
Lornoxicam ++++

COX-1, IC50: 5 nM

 		++++

COX-2, IC50: 8 nM

 		98%
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

 		+++

COX-2, IC50: 50 nM

 		99%
Rofecoxib ++++

COX-2, IC50: 18 nM

 		98%
Asaraldehyde ✔ 98%
Naproxen +

COX-1, IC50: 8.7 μM

 		+

COX-2, IC50: 5.2 μM

 		98%
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

 		+++

COX-2, IC50: 200 nM

 		98%
NS-398 ++

COX-2, IC50: 3.8 μM

 		98%
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

 		+++

COX-2, IC50: 150 nM

 		98%+
Nimesulide +

COX-2, IC50: 26 μM

 		98%
Lumiracoxib ++

COX-1, Ki: 3 μM

 		+++

COX-2, Ki: 60 nM

 		98%
Rutaecarpine ✔ 95%
Celecoxib ++++

COX-2, IC50: 40 nM

 		98%
Carprofen ++++

canine COX2, IC50: 30 nM

 		98%
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

 		++

COX-2 (human), IC50: 3.50 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ibuprofen L-lysine 生物活性

靶点

  • COX
描述 Ibuprofen Lysine is a widely used non-steroidal anti-inflammatory drug (NSAID) that exerts analgesic and anti-inflammatory actions. Ibuprofen Lysine is a continuous infusion instead of a traditional bolus for treating Patent Ductus Arteriosus (PDA). Ibuprofen lysine was stable over 24 hours in Luer-lok polypropylene syringes[3]. The mechanism of action for both indomethacin and ibuprofen lysine is through inhibition of prostaglandin synthesis, resulting in ductal constriction. Ibuprofen lysine has demonstrated significantly less effects on cerebral, renal, and mesenteric blood flow in premature neonates when compared with indomethacin[4]. The positive effects of Hyal 50% on chondral lesions were maintained in the presence of ibuprofen-lysine with the adjunctive effect of an increased limb usage, most likely due to less pain and discomfort[5].

Ibuprofen L-lysine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02583399 Pain Fever Phase 4 Recruiting December 2018 United States, Kentucky ... 展开 >> Kosair Charaties Pediatric Research Unit Recruiting Louisville, Kentucky, United States, 40202 Contact: John W Berkenbosch, MD          United States, Mississippi University of Mississippi Medical Center Recruiting Jackson, Mississippi, United States, 39216 Contact: Dana Lindsay, BSN    601-815-9480       Principal Investigator: Mary Taylor, MD          United States, Texas Children's Medical Center Dallas Recruiting Dallas, Texas, United States, 75235 Contact: John Zhong, MD          Contact: Roxana Polaski, RN    (214) 456-8559       Baylor College of Medicine/Texas Children's Hospital Not yet recruiting Houston, Texas, United States, 77030 Contact: Chris Glover, MD          Contact: Margaret Owens-Stuberfield 收起 <<
NCT02963701 Healthy Volunteers Phase 1 Completed - South Africa ... 展开 >> Bloemfontein Early Phase Clinical Unit, PAREXEL International (South Africa) Bloemfontein, South Africa, 9301 收起 <<
NCT02912650 Post-surgical Pain Following E... 展开 >>xtraction of Molar Teeth 收起 << Phase 3 Completed - United States, Utah ... 展开 >> Jean Brown Research Salt Lake City, Utah, United States, 84124 收起 <<

Ibuprofen L-lysine 参考文献

[1]Pai VB, Sakadjian A, Puthoff TD. Ibuprofen lysine for the prevention and treatment of patent ductus arteriosus. Pharmacotherapy. 2008 Sep;28(9):1162-82.

[2]Mehlisch DR, Jasper RD, et al. Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain. Clin Ther. 1995 Sep-Oct;17(5):852-60.

[3]Garcia J, Garg A, Song Y, Fotios A, Andersen C, Garg S. Compatibility of intravenous ibuprofen with lipids and parenteral nutrition, for use as a continuous infusion. PLoS One. 2018;13(1):e0190577. Published 2018 Jan 3

[4]Pai VB, Sakadjian A, Puthoff TD. Ibuprofen lysine for the prevention and treatment of patent ductus arteriosus. Pharmacotherapy. 2008;28(9):1162-1182

[5]Barbucci R, Fini M, Giavaresi G, et al. Hyaluronic acid hydrogel added with ibuprofen-lysine for the local treatment of chondral lesions in the knee: in vitro and in vivo investigations. J Biomed Mater Res B Appl Biomater. 2005;75(1):42-48

Ibuprofen L-lysine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.84mL

0.57mL

0.28mL

14.19mL

2.84mL

1.42mL

28.37mL

5.67mL

2.84mL

Ibuprofen L-lysine 技术信息

CAS号57469-77-9
分子式C19H32N2O4
分子量 352.468
别名 布洛芬赖氨酸盐 ;Ibuprofen Lysine;(±)-Ibuprofen L-lysine;Arflamin, Ibuprofen lysinate, Ibuprofen lysine, NeoProfen, Saren
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C
溶解度
动物实验配方

PO 0.5% CMC-Na 60 mg/mL clear

Tags: Ibuprofen | 57469-77-9 | (±)-Ibuprofen | COX | COX-1 Inhibitor | Immunology/Inflammation | Apoptosis | Anti-infection | COX | Apoptosis | Parasite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Ibuprofen L-lysine 纯度/质量文件 | Ibuprofen L-lysine 亚型比较 | Ibuprofen L-lysine 生物活性 | Ibuprofen L-lysine 临床数据 | Ibuprofen L-lysine 参考文献 | Ibuprofen L-lysine 实验方案 | Ibuprofen L-lysine 技术信息

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