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N-Methylcytisine
N-甲基金雀花碱 /N-Methylcytisine
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货号：A900570
同义名：
N-甲基野靛碱
/ Caulophylline;N-Me-cy
N-Methylcytisine's nicotinic receptors have high affinity (KD = 50 nM)to nAChR from squid optical ganglia.
N-Methylcytisine 化学结构
N-Methylcytisine 3D分子结构
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N-Methylcytisine 纯度/质量文件 产品仅供科研
货号：A900570
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N-Methylcytisine 质控信息
N-Methylcytisine 生物活性
描述
N-Methylcytisine(NMC), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. Oral administration (1, 4 and 16 mg/kg) of NMC attenuated the DSS(dextran sulfate sodium)-induced clinical symptoms and pathological damage. In addition, NMC treatment significantly reduced myeloperoxidase activity and level of pro-inflammatory cytokines. NMC blocked the activation of NF-κB by inhibiting IκB and IKK phosphorylation[3] [4]
N-Methylcytisine 参考文献
[1] Wang S, Wu H, et al. Determination of N-methylcytisine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 15;990:118-24.
[2] Pliashkevich IuG, Demushkin VP. [N-methylcytisine--a selective ligand of nicotinic receptors of acetylcholine in the CNS] . Biull Eksp Biol Med. 1987 Dec;104(12):690-2. Russian.
[3] Jiao YF, Lu M, Zhao YP, Liu N, Niu YT, Niu Y, Zhou R, Yu JQ. N-Methylcytisine Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Mice by Inhibiting the Inflammatory Response. Molecules. 2018 Feb 25;23(3):510
[4] Terada M, Ishii AI, Kino H, Sano M. Studies on chemotherapy of parasitic helminths (VIII). Effects of some possible neurotransmitters on the motility of Angiostrongylus cantonensis. Jpn J Pharmacol. 1982 Aug;32(4):643-53
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N-Methylcytisine 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
4.90mL
0.98mL
0.49mL
24.48mL
4.90mL
2.45mL
48.96mL
9.79mL
4.90mL
N-Methylcytisine 技术信息
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