N-Methylcytisine's nicotinic receptors have high affinity (KD = 50 nM)to nAChR from squid optical ganglia.

2'-Methoxykurarinone, a natural product isolated and purified from the roots of Sophora flavescens Ait.

Kushenol A, a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors isolated and purified from the roots of Sophora flavescens Ait., exhibits inhibitory activity against sodium-dependent glucose cotransporter 2(SGLT2 and shows selective alpha-glucosidase inhibitory activity.

Sophoflavescenol is a prenylated flavonol, which shows great inhibitory activity with IC50 of 13 nM against phosphodiesterase 5 (PDE5), and also inhibits RLAR, HRAR, AGE, BACE1, AChE and BChE with IC50s of 0.30 μM, 0.17 μM, 17.89 μg/mL, 10.98 μM, 8.37 μM and 8.21 μM, respectively.

Sophocarpine is a naturally-occuring HERG K+ channel blocker with IC50 ranging in 100-300 μM found from plant Sophora flavescens.

Isoxanthohumol, a natural polyphenol isolated and purified from the roots of Sophora flavescens Ait. with antioxidant, anti-inflammatory, and antiangiogenic properties, shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV), and seems to regulate in vivo vascular proliferation and stabilization and the EC-VSMC-inflammatory crosstalk.

Sophoraflavanone G is a small-molecule inhibitor of STAT signaling by targeting upstream signals of STATs that may have therapeutic potential for cancers caused by persistently activated STAT proteins.

Trifolirhizin is purified from the roots of sophora flavescens L. that possesses potential anti-inflammatory and anti-cancer activities.

Leachianone A, a natural product isolated and purified from the roots of Sophora flavescens, possesses a profound cytotoxic activity against human hepatoma cell line HepG2 in vitro, with an IC(50) value of 3.4mg/mL post-48-h treatment.

Oxysophoridine is a natural product isolated and purified from the herb of Sophora alopecuroidos L. Oxysophoridine inhibited N-methyl-D-aspartate NR1 mRNA and protein expression in the cerebral cortex of mice with cerebral ischemia/reperfusion injury.

Sophoranone is a natural product from sophora subprostrata.

Leachianone G, a natural product isolated and purified from the roots of Sophora flavescens Ait., shows inhibitory activities against pancreatic lipase, and may be used as drug candidate to control obesity. Leachianone G exhibits significant antioxidant potentials in the ABTS, ONOO(-), and total ROS assays, and shows potent antiviral activity (IC(50) = 1.6 mg/mL).

8-Prenylkaempferol, a natural product isolated and purified from the roots of Sophora flavescens, is an effective agent for attenuating pro-inflammatory NO induction, induces differentiation/maturation of MC3T3-E1 osteoblasts by BMP-2/p38/Runx2 pathways, and may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated transcriptional activation of NF-κB and IRF-3 and in part by interfering with IκB degradation which subsequently decreases NF-κB translocation.