Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic. In competition studies, glycopyrrolate and ipratropium bromide bind human peripheral lung and human airway smooth muscle (HASM) muscarinic receptors with affinities in the nanomolar range (K1 values 0.5-3.6 nM). Similar to ipratropium bromide, glycopyrrolate showed no selectivity in its binding to the M1-M3 receptors. Glycopyrrolate bind human and guinea-pig airway muscarinic receptors with high affinity[3]. Glycopyrrolate 1 mg was not superior to placebo, whereas 2 mg showed a significant clinical improvement of nocturnal sialorrhea compared with placebo. Glycopyrrolate seemed to be a tolerable anticholinergic agent in the treatment of clozapine-associated sialorrhea[4]. It has now become common practice to use a dosage ratio of 0.2 mg glycopyrrolate to 1.0 mg neostigmine for NMB (reversal of neuromuscular blockade) reversal[5]. Glycopyrrolate is virtually without side effects to the central nervous system because it penetrates the blood-brain barrier poorly. Glycopyrrolate has a slow and erratic absorption from the gastrointestinal system, but even low plasma levels are associated with a distinct and long-lasting antisialogic effect[6].
United Kingdom
... 展开 >> Novartis Investigative Site
Sheffield, South Yorkshire, United Kingdom, S10 2JF
Novartis Investigative Site
Bradford, West Yorkshire, United Kingdom, BD9 6RJ
Novartis Investigative Site
Manchester, United Kingdom, M23 9QZ 收起 <<
United Kingdom
... 展开 >> Novartis Investigative Site
Sheffield, South Yorkshire, United Kingdom, S10 2JF
Novartis Investigative Site
Bradford, West Yorkshire, United Kingdom, BD9 6RJ
Novartis Investigative Site
Manchester, United Kingdom, M23 9QZ 收起 <<
Squamous Cell Head and Neck Ca... 展开 >>ncer
Radiation Induced Xerostomia
Salivary Hypofunction 收起 <<
Phase 1
Phase 2
Recruiting
November 1, 2022
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center, 9000 Rockville Pike
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 prpl@mail.cc.nih.gov 收起 <<
United States, Georgia
... 展开 >>
Raj C. Dedhia
Recruiting
Atlanta, Georgia, United States, 30308
Contact: Raj C Dedhia, MD, MS 404-778-3015 raj.dedhia@emory.edu 收起 <<
Netherlands
... 展开 >> GSK Investigational Site
Beek En Donk, Netherlands, 5741 CG
GSK Investigational Site
Beek, Netherlands, 6191JW
GSK Investigational Site
Eindhoven, Netherlands, 5623 EJ
GSK Investigational Site
Hengelo, Netherlands, 7555 DL
GSK Investigational Site
Hoorn, Netherlands, 1624 NP
GSK Investigational Site
Kloosterhaar, Netherlands, 7694 AC
GSK Investigational Site
Nijverdal, Netherlands, 7442 LS
GSK Investigational Site
Rotterdam, Netherlands, 3051 GV
GSK Investigational Site
Zutphen, Netherlands, 7207 AE
United Kingdom
GSK Investigational Site
Northwood, Middlesex, United Kingdom, HA6 2RN
GSK Investigational Site
London, United Kingdom, EC1M 6BQ
GSK Investigational Site
London, United Kingdom, SW17 0QT
GSK Investigational Site
Sidcup, Kent, United Kingdom, DA14 6LT 收起 <<
United States, New York
... 展开 >>
James J. Peters VA Medical Center
Recruiting
Bronx, New York, United States, 10468
Contact: Brian Lyons 718-584-9000 ext 3128 brian.lyons@va.gov
Contact: Joshua Hobson 718-584-9000 ext 3129 joshua.hobson@va.gov
Principal Investigator: Mark A. Korsten, MD
Sub-Investigator: William A. Bauman, MD
Sub-Investigator: Miroslav Radulovic, MD
Sub-Investigator: Marinella D. Galea, MD
Sub-Investigator: Ann M. Spungen, EdD 收起 <<
United States, California
... 展开 >>
Childrens Hospital Los Angeles ( Site 0030)
Recruiting
Los Angeles, California, United States, 90027
Contact: Study Coordinator 323-361-8649
Lucille Packard Children's Hospital ( Site 0006)
Completed
Palo Alto, California, United States, 94304
United States, District of Columbia
Children's National Medical Center ( Site 0008)
Recruiting
Washington, District of Columbia, United States, 20010
Contact: Study Coordinator 202-476-2025
United States, Michigan
C.S. Mott Children's Hospital/ University of Michigan Medical center ( Site 0014)
Recruiting
Ann Arbor, Michigan, United States, 48109-4245
Contact: Study Coordinator 734-763-2435
United States, New Jersey
Saint Peter's University Hospital [New Brunswick, NJ] ( Site 0009)
Completed
New Brunswick, New Jersey, United States, 08901
United States, North Carolina
Duke University Medical Center ( Site 0019)
Recruiting
Durham, North Carolina, United States, 27710
Contact: Study Coordinator 919-681-4877
United States, Pennsylvania
Children's Hospital of Pittsburgh of UPMC ( Site 0005)
Recruiting
Pittsburgh, Pennsylvania, United States, 15224
Contact: Study Coordinator 412-692-6390 收起 <<
United States, Michigan
... 展开 >>
Henry Ford Health Systems
Not yet recruiting
Detroit, Michigan, United States, 48202
Contact: Mary Jarzebowski, MD 313-282-5673 mjarzeb1@hfhs.org 收起 <<
United States, Florida
... 展开 >>
Clinical Research of West Florida, Inc.
Clearwater, Florida, United States, 33765
United States, North Carolina
American Health Research, Inc.
Charlotte, North Carolina, United States, 28207
North Carolina Clinical Research
Raleigh, North Carolina, United States, 27607
United States, Oregon
Clinical Research Institute of Southern Oregon, PC
Medford, Oregon, United States, 97504
United States, South Carolina
Palmetto Medical Research Associates, LLC
Easley, South Carolina, United States, 29640
Greenville Pharmaceutical Research, Inc.
Greenville, South Carolina, United States, 29615
Upstate Pharmaceutical Research
Greenville, South Carolina, United States, 29615
S. Carolina
Spartanburg, South Carolina, United States, 29303
Spartanburg Medical Research
Spartanburg, South Carolina, United States, 29303
CU Pharmaceutical Research
Union, South Carolina, United States, 29379 收起 <<
Korea, Republic of
... 展开 >>
Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine
Recruiting
Suwon, Seoul, Korea, Republic of
Contact: Ji Eun Kim 82-31-219-5575 收起 <<
United States, North Carolina
... 展开 >>
Duke Asthma, Allergy, and Airway Center
Recruiting
Durham, North Carolina, United States, 27705
Contact: Erika Coleman 919-479-0861 收起 <<
United States, West Virginia
... 展开 >>
WVU Healthcare Ruby Memorial Hospital
Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Pavithra Ranganathan, MD 304-598-4929 ranganathanp@wvuhealthcare.com
Contact: Matthew Ellison, MD 304-598-4929 EllisonMa@wvuhealthcare.com
Principal Investigator: Pavithra Ranganathan, MD
Sub-Investigator: Matthew Ellison, MD 收起 <<
Vocal Cord Function in Neck Pr... 展开 >>ocedures 收起 <<
Not Applicable
Recruiting
September 26, 2020
United States, New York
... 展开 >>
Mount Sinai Queens
Not yet recruiting
Long Island City, New York, United States, 11102
Mount Sinai Beth Israel
Recruiting
New York, New York, United States, 10003
Mount Sinai West
Recruiting
New York, New York, United States, 10019
Mount Sinai St. Luke's
Recruiting
New York, New York, United States, 10025
The Mount Sinai Hospital
Recruiting
New York, New York, United States, 10029 收起 <<
United States, Arizona
... 展开 >>
Pearl Investigative Site
Glendale, Arizona, United States
United States, California
Pearl Investigative Site
Rancho Mirage, California, United States
United States, Connecticut
Pearl Investigative Site
Waterbury, Connecticut, United States
United States, Florida
Pearl Investigative Site
Clearwater, Florida, United States, 33765
Pearl Investigative Site
Clearwater, Florida, United States
Pearl Investigative Site
Pensacola, Florida, United States
Pearl Investigative Site
Winter Park, Florida, United States, 32789
United States, Louisiana
Pearl Investigative Site
Lafayette, Louisiana, United States
United States, Massachusetts
Pearl Investigative Site
North Dartmouth, Massachusetts, United States
United States, Minnesota
Pearl Investigative Site
Fridley, Minnesota, United States
United States, Missouri
Pearl Investigative Site
St. Louis, Missouri, United States
United States, New Jersey
Pearl Investigative Site
Summit, New Jersey, United States
United States, Ohio
Pearl Investigative Site
Cincinnati, Ohio, United States
United States, Oregon
Pearl Investigative Site
Medford, Oregon, United States, 97504
Pearl Investigative Site
Medford, Oregon, United States
United States, South Carolina
Pearl Investigative Site
Rock Hill, South Carolina, United States
Pearl Investigative Site
Spartanburg, South Carolina, United States, 29303
United States, Texas
Pearl Investigative Site
San Antonio, Texas, United States
United States, West Virginia
Pearl Investigative Site
Morgantown, West Virginia, United States 收起 <<
United States, New York
... 展开 >>
James J. Peters VA Medical Center
Recruiting
The Bronx, New York, United States, 10468
Contact: Brian Lyons 718-584-9000 ext 3128 brian.lyons@va.gov
Contact: Joshua Hobson 718-584-9000 ext 3129 joshua.hobson@va.gov
Principal Investigator: Mark A. Korsten, MD
Sub-Investigator: William A. Bauman, MD
Sub-Investigator: Miroslav Radulovic, MD
Sub-Investigator: Marinella D. Galea, MD
Sub-Investigator: Ann M. Spungen, EdD
Sub-Investigator: Gregory Schilero, MD 收起 <<
Malignant Neoplasms of Urinary... 展开 >> Tract
Bladder Cancer 收起 <<
Phase 4
Recruiting
September 2020
United States, Texas
... 展开 >>
University of Texas MD Anderson Cancer Center
Recruiting
Houston, Texas, United States, 77030
Contact: Clinical Research Operations CR_Study_Registration@mdanderson.org 收起 <<
United States, California
... 展开 >>
UCSF Helen Diller Cancer Center
San Francisco, California, United States, 94115
UCSF Moffitt-Long Hospital
San Francisco, California, United States, 94143 收起 <<
United States, Missouri
... 展开 >>
Novartis Investigator Site
Saint Louis, Missouri, United States
United States, North Carolina
Novartis Investigator Site
Charlotte, North Carolina, United States
Novartis Investigator site
Raleigh, North Carolina, United States
Belgium
Novartis Investigator Site
Antwerpen, Belgium
Novartis Investigator Site
Gent, Belgium
Novartis Investigator Site
Jambes, Belgium
Novartis Investigator Site
Saint Vith, Belgium
Canada
Novartis Investigator Site
Moncton, Canada
Novartis Investigator Site
Montreal, Canada
Novartis Investigator site
Toronto, Canada
Germany
Novartis Investigator Site
Bad Worishofen, Germany
Novartis Investigator Site
Berlin, Germany
Novartis Investigator Site
Frankfurt, Germany
Novartis Investigator Site
Mainz, Germany
Novartis Investigator Site
Rudersdorf, Germany
Novartis Investigator Site
Wiesbaden, Germany
Netherlands
Novartis Investigator Site
Almelo, Netherlands
Novartis Investigator Site
Breda, Netherlands
Novartis Investigator site
Eindhoven, Netherlands
Novartis investigator site
Heerlen, Netherlands
Novartis Investigator Site
Nijmegen, Netherlands
Novartis Investigator Site
Veldhoven, Netherlands 收起 <<
United States, Alabama
... 展开 >>
Universityof Alabama
Recruiting
Birmingham, Alabama, United States, 35294
Contact: Erica Anderson eanderson@uabmc.edu
Principal Investigator: Mark Dransfield
United States, California
University of California
Recruiting
Los Angeles, California, United States, 90095
Contact: Miguel Villarreal MiguelVillarreal@mednet.ucla.edu
Principal Investigator: Igor Barjaktarevic, MD, PhD
University of California
Recruiting
San Francisco, California, United States, 94143
Contact: Sundos Yassin sundos.yassin@ucsf.edu
Principal Investigator: Stephen Lazarus, MD
LABIOMED at Harbor-UCLA Medical Center
Recruiting
Torrance, California, United States, 90502
Contact: Carmen Lopez-Garcia Clopez_garcia@labiomed.org
Principal Investigator: William Stringer, MD
United States, Illinois
University of Illinois
Recruiting
Chicago, Illinois, United States, 60608
Contact: Lauren Castro lschra3@uic.edu
Principal Investigator: Jerry Krishnan, MD, PhD
Northwestern University
Recruiting
Chicago, Illinois, United States, 60657
Contact: Jenny Hixon j-franzen@northwestern.edu
Principal Investigator: Ravi Kalhan
United States, Iowa
University of Iowa
Recruiting
Iowa City, Iowa, United States, 52242
Contact: Fozia Ghaforr fozia-ghafoor@uiowa.edu
Principal Investigator: Alejandro Comellas
United States, Maryland
Johns Hopkins University
Recruiting
Baltimore, Maryland, United States, 21224
Contact: Cheryl Clare cdaniel9@jhu.edu
Principal Investigator: Bob Wise
United States, Michigan
University of Michigan
Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Crystal Cutlip ccutlip@umich.edu
Principal Investigator: MeiLan Han
United States, Minnesota
Minneapolis VA Medical Center
Recruiting
Minneapolis, Minnesota, United States, 55417
Contact: Allison Aase Allison.Aase@va.gov
Principal Investigator: Chris Wendt, MD
Minnesota Health partners
Recruiting
Saint Paul, Minnesota, United States, 55130
Contact: Pamela Neuenfeldt, MPH pamela.j.neuenfeldt@healthpartners.com
Principal Investigator: Charlene McEvoy
United States, New York
Cornell University
Recruiting
New York, New York, United States, 10021
Contact: Matthew Marcelino mam2225@med.cornell.edu
Principal Investigator: Robert kaner, MD
United States, North Carolina
Duke University
Recruiting
Durham, North Carolina, United States, 27705
Contact: Erika Coleman erika.coleman@duke.edu
Principal Investigator: Neil MacIntyre
United States, Pennsylvania
Temple University
Recruiting
Philadelphia, Pennsylvania, United States, 19140
Contact: Dee Fehrle Delores.Fehrle@tuhs.temple.edu
Principal Investigator: Gerard Criner, MD
University of Pittsburgh
Recruiting
Pittsburgh, Pennsylvania, United States, 15213
Contact: Elizabeth Stempkowski stempkowskiem@upmc.edu
Principal Investigator: Toru Nyunoya, MD
United States, Texas
Baylor College of Medicine
Recruiting
Houston, Texas, United States, 77505
Contact: Brock Melissa mbrock@bcm.edu
Principal Investigator: Nicola Hanania, MD, MS
United States, Utah
University of Utah
Recruiting
Salt Lake City, Utah, United States, 84132
Contact: Newsha Sedghi u0984618@utah.edu
Principal Investigator: Kanner Richard 收起 <<
United States, New Jersey
... 展开 >>
Memoral Sloan Kettering Basking Ridge
Recruiting
Basking Ridge, New Jersey, United States, 07920
Contact: German Echeverry, MD 212-639-8865
United States, New York
Memorial Sloan Kettering Cancer Center @ Commack
Recruiting
Commack, New York, United States, 11725
Contact: German Echeverry, MD 212-639-8865
Memoral Sloan Kettering Westchester
Recruiting
Harrison, New York, United States, 10604
Contact: German Echeverry, MD 212-639-8865
Memorial Sloan - Kettering Cancer Center
Recruiting
New York, New York, United States, 10021
Contact: German Echeverry, MD 212-639-8865 收起 <<
United Kingdom
... 展开 >> Lancashire Care NHS Foundation Trust
Preston, Lancashire, United Kingdom
Mersey Care NHS Trust
Liverpool, Merseyside, United Kingdom 收起 <<
United States, California
... 展开 >>
California Dermatology & Clinical Research Institute
Encinitas, California, United States, 92024
Center For Dermatology Clinical Research
Fremont, California, United States, 94538
United States, Florida
Olympian Clinical Research
Tampa, Florida, United States, 33609
Kenneth R. Beer MD
West Palm Beach, Florida, United States, 33401
United States, Indiana
Shideler Clinical Research Center
Carmel, Indiana, United States, 46032
United States, Missouri
Saint Louis University Dermatology
Saint Louis, Missouri, United States, 63122
United States, Ohio
Haber Dermatology and Cosmetic Surgery
Beachwood, Ohio, United States, 44122
United States, Tennessee
Rivergate Dermatology Clinical Research Center, PLLC
Goodlettsville, Tennessee, United States, 37072
United States, Texas
DermResearch, Inc
Austin, Texas, United States, 78759
United States, Utah
Dermatology Research Center, Inc.
Salt Lake City, Utah, United States, 84117
United States, Virginia
Virginia Clinical Research, Inc.
Norfolk, Virginia, United States, 23507
United States, Washington
Dermatology Associates
Seattle, Washington, United States, 98101
Women's Clinical Research Center
Seattle, Washington, United States, 98105
Premier Clinical Research
Spokane, Washington, United States, 99204
Canada
Innovaderm Research Inc.
Montreal, Canada, H2K 4L5 收起 <<
United States, Colorado
... 展开 >>
Rocky Mountain Pediatrics
Lakewood, Colorado, United States, 80214
United States, Georgia
Child Neurology Associates, PC
Atlanta, Georgia, United States, 30342
United States, New York
St. Mary's for Children
Bayside, New York, United States, 11360
United States, Ohio
Akron's Childrens
Akron, Ohio, United States, 44308
Hattie Larltham Center for Children with Disabilities
Mantua, Ohio, United States, 44255
United States, Oklahoma
The Children's Center
Bethany, Oklahoma, United States, 73008
United States, Texas
Alamo City Clinical Research
San Antonio, Texas, United States, 78258 收起 <<
United Kingdom
... 展开 >> Queen Anne Street Medical Center
London, United Kingdom, W1G 8HU
Medicines evaluation Unit Ltd.
Manchester, United Kingdom, M23 9QZ 收起 <<
United States, Iowa
... 展开 >>
University of Iowa
Recruiting
Iowa City, Iowa, United States, 52242
Contact: Kokila N Thenuwara, MD 319-541-8634 kokila-thenuwara@uiowa.edu
Principal Investigator: Kokila N Thenuwara, MD 收起 <<
United States, Arkansas
... 展开 >>
Burke Pharmaceutical Research
Hot Springs, Arkansas, United States, 71913
Gary M. Petrus, MD, PA
Little Rock, Arkansas, United States, 72202
United States, California
California Dermatology & Clinical Research Institute
Encinitas, California, United States, 92024
Center For Dermatology Clinical Research
Fremont, California, United States, 94538
United States, Florida
Florida Academic Dermatology Center
Miami, Florida, United States, 33136
Kenneth R. Beer, MD, PA
West Palm Beach, Florida, United States, 33401
United States, Indiana
Shideler Clinical Research Center
Carmel, Indiana, United States, 46032
United States, Kansas
Cypress Medical Research Center, LLC
Wichita, Kansas, United States, 67226
United States, Minnesota
Minnesota Clinical Study Center
Fridley, Minnesota, United States, 55432
United States, Missouri
Saint Louis University Dermatology
Saint Louis, Missouri, United States, 63122
United States, Nebraska
Skin Specialists, PC
Omaha, Nebraska, United States, 68144
United States, New Jersey
The Dermatology Group, PC
Verona, New Jersey, United States, 07044
United States, Oregon
Oregon Medical Research Center
Portland, Oregon, United States, 97223
United States, Texas
J&S Studies, Inc.
College Station, Texas, United States, 77845
Clinical Trials of Texas, Inc.
San Antonio, Texas, United States, 78229
United States, Utah
Dermatology Research Center, Inc.
Salt Lake City, Utah, United States, 84117
United States, Virginia
Virginia Clinical Research, Inc.
Norfolk, Virginia, United States, 23507
Westend Dermatology Associates
Richmond, Virginia, United States, 23233
United States, Washington
Dermatology Associates
Seattle, Washington, United States, 98101
Women's Clinical Research Center
Seattle, Washington, United States, 98105
Premier Clinical Research
Spokane, Washington, United States, 99204 收起 <<
United States, California
... 展开 >>
Los Angeles Biomedical Institute, Inc (LABIOMED)
Recruiting
Torrance, California, United States, 90509
Contact: William Stringer, MD 424-571-7626 wstringer@labiomed.org
Contact: Leticia Diaz, RN 310-222-8022 ext 7258 ldiaz@labiomed.org
Principal Investigator: William W Stringer, MD 收起 <<
Korea, Republic of
... 展开 >>
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine
Seoul, Korea, Republic of, 03722 收起 <<
Korea, Republic of
... 展开 >>
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine
Recruiting
Seoul, Korea, Republic of, 03722
Contact: Ki-Young Lee, MD 收起 <<
Korea, Republic of
... 展开 >>
Seoul National University of Hospital
Recruiting
Seoul, Korea, Republic of, Korea, Republic of
Contact: Hee-Pyoung Park, PhD +82-10-2971-7647 hppark@snu.ac.kr
Principal Investigator: Hyun-Chang Kim, MD
Principal Investigator: Hee-Pyoung Park, PhD 收起 <<
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