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呋虫胺 /Dinotefuran {[allProObj[0].p_purity_real_show]}

货号:A211386 同义名: MTI-446;1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine

Dinotefuran is the third generation of neonicotinoid group,which works through inhibiting nAchRs.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Dinotefuran 化学结构 CAS号:165252-70-0
Dinotefuran 化学结构
CAS号:165252-70-0
Dinotefuran 3D分子结构
CAS号:165252-70-0
Dinotefuran 化学结构 CAS号:165252-70-0
Dinotefuran 3D分子结构 CAS号:165252-70-0
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Dinotefuran 纯度/质量文件 产品仅供科研

货号:A211386 标准纯度: {[allProObj[0].p_purity_real_show]}
批次查询: 批次纯度:

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产品名称 AChE AChR mAChR nAChR 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

98%
Loganin ++

AChE, IC50: 3.95 μM

99%+
topride HCl ++

AChE, IC50: 2.04 μM

98%
Dehydroevodiamine HCl 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

99%+
Palmatine ++

AChE, IC50: 0.51 μM

98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

98%
Trospium chloride 99%
Tiotropium Bromide Monohydrate 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

98%
Hexamethonium Bromide 99%
Pancuronium dibromide 98%
Neostigmine bromide 98%
Orphenadrine citrate 98%
Oxybutynin 98%
Irsogladine PDE 98%
Pyridostigmine bromide 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

98%
Paroxetine hydrochloride 97%
Rocuronium Bromide 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

98%
Diphenmanil methylsulfate 98%
Umeclidinium bromide 95%
Otilonium bromide 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

98%
Ipratropium bromide 98%
Diphenidol HCl 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

98%
Oxybutynin chloride 99%
Pentoxyverine citrate 98%
Solifenacin 98%
Catharanthine 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Dinotefuran 生物活性

描述 Dinotefuran is a furanicotinyl insecticide belonging to the third generation of neonicotinoids. It acts specifically on the nervous system of fleas by inhibiting a nicotinic subclass of acetylcholine receptors. In vitro, the combination of dinotefuran and fipronil in a single formulation exhibited strong synergistic insecticidal activity against C. felis, and also proved effective on artificially infested cats[3]. Moreover, exposure to DIN (Dinotefuran) in peripubertal male mice causes hyperactivity and a disturbance of dopaminergic signaling[4].

Dinotefuran 参考文献

[1]Liu T, Wang X, et al. Biochemical and genetic toxicity of dinotefuran on earthworms (Eisenia fetida). Chemosphere. 2017 Jun;176:156-164.

[2]Chen Z, Dong F, et al. Response surface methodology for the enantioseparation of dinotefuran and its chiral metabolite in bee products and environmental samples by supercritical fluid chromatography/tandem mass spectrometry. J Chromatogr A. 2015 Sep 4;1410:181-9.

[3]Delcombel R, Karembe H, Nare B, Burton A, Liebenberg J, Fourie J, Varloud M. Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats. Parasit Vectors. 2017 Jul 19;10(1):341. doi: 10.1186/s13071-017-2272-8. PMID: 28724438; PMCID: PMC5517796.

[4]Yoneda N, Takada T, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N. Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice. J Vet Med Sci. 2018 Apr 18;80(4):634-637. doi: 10.1292/jvms.18-0014. Epub 2018 Feb 9. PMID: 29434093; PMCID: PMC5938192.

Dinotefuran 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.95mL

0.99mL

0.49mL

24.73mL

4.95mL

2.47mL

49.45mL

9.89mL

4.95mL

Dinotefuran 技术信息

CAS号165252-70-0
分子式C7H14N4O3
分子量 202.21
别名 MTI-446;1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine;Nidinotefuran
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

H2O: 50 mg/mL(247.27 mM),配合低频超声助溶

动物实验配方
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