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Dinotefuran

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Chemical Structure| 165252-70-0 同义名 : MTI-446;1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine;Nidinotefuran
CAS号 : 165252-70-0
货号 : A211386
分子式 : C7H14N4O3
纯度 : 98%
分子量 : 202.21
MDL号 : MFCD06795001
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 50 mg/mL(247.27 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Dinotefuran is a furanicotinyl insecticide belonging to the third generation of neonicotinoids. It acts specifically on the nervous system of fleas by inhibiting a nicotinic subclass of acetylcholine receptors. In vitro, the combination of dinotefuran and fipronil in a single formulation exhibited strong synergistic insecticidal activity against C. felis, and also proved effective on artificially infested cats[3]. Moreover, exposure to DIN (Dinotefuran) in peripubertal male mice causes hyperactivity and a disturbance of dopaminergic signaling[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.95mL

0.99mL

0.49mL

24.73mL

4.95mL

2.47mL

49.45mL

9.89mL

4.95mL
参考文献

[1]Liu T, Wang X, et al. Biochemical and genetic toxicity of dinotefuran on earthworms (Eisenia fetida). Chemosphere. 2017 Jun;176:156-164.

[2]Chen Z, Dong F, et al. Response surface methodology for the enantioseparation of dinotefuran and its chiral metabolite in bee products and environmental samples by supercritical fluid chromatography/tandem mass spectrometry. J Chromatogr A. 2015 Sep 4;1410:181-9.

[3]Delcombel R, Karembe H, Nare B, Burton A, Liebenberg J, Fourie J, Varloud M. Synergy between dinotefuran and fipronil against the cat flea (Ctenocephalides felis): improved onset of action and residual speed of kill in adult cats. Parasit Vectors. 2017 Jul 19;10(1):341. doi: 10.1186/s13071-017-2272-8. PMID: 28724438; PMCID: PMC5517796.

[4]Yoneda N, Takada T, Hirano T, Yanai S, Yamamoto A, Mantani Y, Yokoyama T, Kitagawa H, Tabuchi Y, Hoshi N. Peripubertal exposure to the neonicotinoid pesticide dinotefuran affects dopaminergic neurons and causes hyperactivity in male mice. J Vet Med Sci. 2018 Apr 18;80(4):634-637. doi: 10.1292/jvms.18-0014. Epub 2018 Feb 9. PMID: 29434093; PMCID: PMC5938192.