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去氢吴茱萸碱 /Dehydroevodiamine {[allProObj[0].p_purity_real_show]}

货号:A787273 同义名: DHED Ambeed 开学季,买赠积分,赢豪礼

Dehydroevodiamine is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.

Dehydroevodiamine 化学结构 CAS号:67909-49-3
Dehydroevodiamine 化学结构
CAS号:67909-49-3
Dehydroevodiamine 3D分子结构
CAS号:67909-49-3
Dehydroevodiamine 化学结构 CAS号:67909-49-3
Dehydroevodiamine 3D分子结构 CAS号:67909-49-3
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Dehydroevodiamine 纯度/质量文件 产品仅供科研

货号:A787273 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 NF-κB 其他靶点 纯度
Pyrrolidinedithiocarbamate ammonium {[allProObj[0].p_purity_real_show]}
QNZ ++++

NF-κB, IC50: 11 nM

{[allProObj[0].p_purity_real_show]}
Sodium 4-Aminosalicylate Dihydrate {[allProObj[0].p_purity_real_show]}
Sodium Salicylate {[allProObj[0].p_purity_real_show]}
Parthenolide p53 {[allProObj[0].p_purity_real_show]}
JSH-23 +

NF-κB, IC50: 7.1 μM

{[allProObj[0].p_purity_real_show]}
Phenethyl caffeate {[allProObj[0].p_purity_real_show]}
Andrographolide {[allProObj[0].p_purity_real_show]}
Curcumin HDAC,Nrf2 {[allProObj[0].p_purity_real_show]}
SC75741 +++

NF-κB, EC50: 200 nM

{[allProObj[0].p_purity_real_show]}
CBL0137 HCl ++

NF-κB, EC50: 0.47 μM

p53 {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 COX COX-1 COX-2 其他靶点 纯度
Piroxicam {[allProObj[0].p_purity_real_show]}
Salicylic acid {[allProObj[0].p_purity_real_show]}
Phenacetin {[allProObj[0].p_purity_real_show]}
Etodolac {[allProObj[0].p_purity_real_show]}
Flunixin meglumine {[allProObj[0].p_purity_real_show]}
Ibuprofen L-lysine {[allProObj[0].p_purity_real_show]}
Nabumetone {[allProObj[0].p_purity_real_show]}
Acemetacin {[allProObj[0].p_purity_real_show]}
Diflunisal {[allProObj[0].p_purity_real_show]}
Pranoprofen {[allProObj[0].p_purity_real_show]}
Ampiroxicam {[allProObj[0].p_purity_real_show]}
Meloxicam {[allProObj[0].p_purity_real_show]}
Sulindac {[allProObj[0].p_purity_real_show]}
Ketoprofen {[allProObj[0].p_purity_real_show]}
Mefenamic Acid {[allProObj[0].p_purity_real_show]}
Bromfenac sodium {[allProObj[0].p_purity_real_show]}
Oxaprozin {[allProObj[0].p_purity_real_show]}
Aspirin {[allProObj[0].p_purity_real_show]}
Nepafenac {[allProObj[0].p_purity_real_show]}
Zaltoprofen {[allProObj[0].p_purity_real_show]}
Salicin {[allProObj[0].p_purity_real_show]}
Suprofen {[allProObj[0].p_purity_real_show]}
Xanthohumol {[allProObj[0].p_purity_real_show]}
Parecoxib {[allProObj[0].p_purity_real_show]}
Tolfenamic Acid +++

COX-2, IC50: 0.2 μM

{[allProObj[0].p_purity_real_show]}
Etoricoxib {[allProObj[0].p_purity_real_show]}
Niflumic Acid {[allProObj[0].p_purity_real_show]}
Valdecoxib ++++

COX-2, IC50: 5 nM

{[allProObj[0].p_purity_real_show]}
Ibuprofen +

COX-1, IC50: 13 μM

+

COX-2, IC50: 370 μM

{[allProObj[0].p_purity_real_show]}
Indomethacin ++

COX1, IC50: 0.28 μM

+

COX-2, IC50: 14 μM

{[allProObj[0].p_purity_real_show]}
Lornoxicam ++++

COX-1, IC50: 5 nM

++++

COX-2, IC50: 8 nM

{[allProObj[0].p_purity_real_show]}
Meclofenamic acid sodium ++++

COX-1, IC50: 40 nM

+++

COX-2, IC50: 50 nM

{[allProObj[0].p_purity_real_show]}
Rofecoxib ++++

COX-2, IC50: 18 nM

{[allProObj[0].p_purity_real_show]}
Asaraldehyde {[allProObj[0].p_purity_real_show]}
Naproxen +

COX-1, IC50: 8.7 μM

+

COX-2, IC50: 5.2 μM

{[allProObj[0].p_purity_real_show]}
Diclofenac Sodium Salt +++

COX-1, IC50: 60 nM

+++

COX-2, IC50: 200 nM

{[allProObj[0].p_purity_real_show]}
NS-398 ++

COX-2, IC50: 3.8 μM

{[allProObj[0].p_purity_real_show]}
Amfenac Sodium Hydrate ++

COX-1, IC50: 250 nM

+++

COX-2, IC50: 150 nM

{[allProObj[0].p_purity_real_show]}
Nimesulide +

COX-2, IC50: 26 μM

{[allProObj[0].p_purity_real_show]}
Lumiracoxib ++

COX-1, Ki: 3 μM

+++

COX-2, Ki: 60 nM

{[allProObj[0].p_purity_real_show]}
Rutaecarpine {[allProObj[0].p_purity_real_show]}
Celecoxib ++++

COX-2, IC50: 40 nM

{[allProObj[0].p_purity_real_show]}
Carprofen ++++

canine COX2, IC50: 30 nM

{[allProObj[0].p_purity_real_show]}
Ketorolac ++

COX-1 (human), IC50: 1.23 μM

++

COX-2 (human), IC50: 3.50 μM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。
产品名称 eNOS iNOS nNOS 其他靶点 纯度
1400W 2HCl +

eNOS, Ki: 50 μM

++++

iNOS, Kd: <7 nM

++

nNOS, Ki: 2 μM

{[allProObj[0].p_purity_real_show]}
L-NAME HCl +++

eNOS, Ki: 39 nM

++

iNOS, Ki: 4.4 μM

+++

nNOS, Ki: 15 nM

{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Dehydroevodiamine 生物活性

描述 Dehydroevodiamine (DHED) is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, and has an antiarrhythmic effect in guinea-pig ventricular myocytes[3]. Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages[4]. Similarly to the cholinesterase inhibitor, physostigmine (0.03--0.3 mg/kg, i.p.), dehydroevodiamine (0.75--12.0 mg/kg, i.p.) administered 30 min before the training trial, immediately after the training trial, and 30 min before the retention test significantly improved scopolamine- and beta-amyloid peptide-(25--35)-induced amnesia[5]. DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats[6]. DHED could suppress the overactivation of GSK-3 (glycogen synthase kinase-3) and improve tau hyperphosphorylation and spatial memory deficit of the rats[7]. DHED (Pre-incubation of the brain slices with DHED) can attenuate CA(calyculin A)-induced tau hyperphosphorylation at multiple AD-related sites in metabolically active rat brain slices[8].

Dehydroevodiamine 参考文献

[1]Shin KY, Kim KY, Suh YH. Dehydroevodiamine·HCl enhances cognitive function in memory-impaired rat models. Korean J Physiol Pharmacol. 2017 Jan;21(1):55-64.

[2]Shin KY, Noh SJ, et al. Dehydroevodiamine•HCl Protects Against Memory Impairment and Cerebral Amyloid-β Production in Tg2576 Mice by Acting as a γ-Secretase Inhibitor. CNS Neurol Disord Drug Targets. 2016;15(8):935-944.

[3]Loh SH, Tsai YT, Lee CY, Chang CY, Tsai CS, Cheng TH, Lin CI. Antiarrhythmic effects of dehydroevodiamine in isolated human myocardium and cardiomyocytes. J Ethnopharmacol. 2014 May 14;153(3):753-62

[4]Noh EJ, Ahn KS, Shin EM, Jung SH, Kim YS. Inhibition of lipopolysaccharide-induced iNOS and COX-2 expression by dehydroevodiamine through suppression of NF-kappaB activation in RAW 264.7 macrophages. Life Sci. 2006 Jul 10;79(7):695-701

[5]Wang HH, Chou CJ, Liao JF, Chen CF. Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5

[6]Shin KY, Kim KY, Suh YH. Dehydroevodiamine•HCl enhances cognitive function in memory-impaired rat models. Korean J Physiol Pharmacol. 2017 Jan;21(1):55-64

[7]Peng JH, Zhang CE, Wei W, Hong XP, Pan XP, Wang JZ. Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats. Neuropharmacology. 2007 Jun;52(7):1521-7

[8]Fang J, Liu R, Tian Q, Hong XP, Wang SH, Cao FY, Pan XP, Wang JZ. Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices. Acta Pharmacol Sin. 2007 Nov;28(11):1717-23

Dehydroevodiamine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.32mL

0.66mL

0.33mL

16.59mL

3.32mL

1.66mL

33.18mL

6.64mL

3.32mL

Dehydroevodiamine 技术信息

CAS号67909-49-3
分子式C19H15N3O
分子量 301.342
别名 DHED
运输蓝冰
存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 7 mg/mL(23.23 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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