CAY10526是特异性的微粒体前列腺素 E2 合成酶 1 (mPGES1) 抑制剂。它通过选择性调节 mPGES1 表达抑制 PGE2 的产生，但不影响 COX-2。在黑色素瘤移植模型中，CAY10526 抑制肿瘤生长并增加细胞凋亡，同时降低 BCL-2 和 BCL-XL (抗凋亡) 蛋白水平，并增加 BAX 和 BAK (促凋亡) 以及切割的 caspase 3 水平，在三种表达 mPGES1 的黑色素瘤细胞系中抑制细胞活力 (IC50 < 5 μM)。

hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.

Pizuglanstat is a hematopoietic prostaglandin synthase inhibitor.

HPGDS inhibitor 1 is a selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.

Limaprost is a PGE1 analog and potent platelet adhesion inhibitor.

AT 56 is an orally active L-PGDS inhibitor with IC50 value of 95μM. It inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.

Bismuth subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin G/H Synthase 1/2.

Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.

Esflurbiprofen, also known as BTS-24332; SFPP; TT-063, is a cyclooxygenase (COX) inhibitor indicated for the treatment of osteoarthritis pain and inflammation.

Dehydroevodiamine is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.

Dehydroevodiamine HCl is an alkaloid isolated from E. rutaecarpa and possesses anti-inflammatory, antiarrhythmic, hypotensive, and anti-amnesic biological activities.

PGS-IN-1是一种有效的前列腺素合成酶抑制剂，IC50 为 0.28 μM，亦可抑制 5-脂氧合酶的活性，IC50 为 1.05 μM。

Sinensetin is a methylated flavone isolated and purified from the fruit of Citrus aurantium L. with antimutagenic, anticancer, and anti-inflammatory activities.

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.

GSK-2894631A is a highly potent and selective HPGDS inhibitor with IC50 value of 9.9nM.