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Rocuronium Bromide

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Chemical Structure| 119302-91-9 同义名 : ORG 9426 Bromide;Rocuronium (bromide);(+)-Rocuronium;ORG 9426
CAS号 : 119302-91-9
货号 : A248225
分子式 : C32H53BrN2O4
纯度 : 98%
分子量 : 609.68
MDL号 : MFCD00867768
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(172.22 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(164.02 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • AChR
描述 Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia. Rocuronium bromide induced inflammation and pain in CPAE cells[3]. Rocuronium reduced the indirectly elicited twitch tensions in normal (IC50 = 9.84 μM) and all pretreated diaphragms in a concentration-dependent fashion[4]. Rocuronium possesses a very stable cardiovascular profile and a rapid onset of action[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.64mL

0.33mL

0.16mL

8.20mL

1.64mL

0.82mL

16.40mL

3.28mL

1.64mL
参考文献

[1]Narimatsu E, Niiya T, et al. Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependent fashion. Am J Emerg Med. 2012 Jul;30(6):901-7.

[2]Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8.

[3]Baek SB, Shin MS, Han JH, Moon SW, Chang B, Jeon JW, Yi JW, Chung JY. Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E2 Synthesis in Endothelial Cells. Int Neurourol J. 2016 Dec;20(4):296-303.

[4]Narimatsu E, Niiya T, Takahashi K, Yamauchi M, Yamakage M. Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependent fashion. Am J Emerg Med. 2012 Jul;30(6):901-7.

[5]Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8.