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白藜芦醇 /Resveratrol 98%

货号：A419526 同义名： trans-Resveratrol;SRT501

Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.

Resveratrol 化学结构
CAS号：501-36-0

Resveratrol 3D分子结构
CAS号：501-36-0

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Resveratrol 纯度/质量文件产品仅供科研

货号：A419526 标准纯度： 98% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

DNA 亚型比较
cAMP 亚型比较
NF-κB 亚型比较

产品名称	DNA synthesis ↓ ↑	helicase ↓ ↑	RdRp ↓ ↑	ribonucleotide reductase ↓ ↑	tRNA synthetase ↓ ↑	YB-1 ↓ ↑	其他靶点	纯度
Fexinidazole	✔							99%+
Daptomycin	✔							98%
Blasticidin S·HCl	✔							99%+
Metronidazole	✔							99%+
Daunorubicin HCl	+++ DNA synthesis, Ki: 20 nM							98%
Triglycidyl isocyanurate	✔						p53	98+%
Nedaplatin	✔							99%+
Bendamustine	✔							99%+
Trifluridine	✔							99%+
Robinetin	✔							99%+
Carboplatin	✔							99%
Cidofovir	✔							99%
Cisplatin	✔							99%
Cytarabine	++++ DNA synthesis, IC50: 16 nM							99%+
Acelarin	++++ DNA synthesis, EC50: 0.2 nM							99%+
Oxaliplatin	✔							99%+
YK-4-279		✔						99%+
ML216		+ BLM^636-1298, IC50: 0.97 μM BLM^full-length, IC50: 2.98 μM						99%+
RK-33		✔						99%+
Brr2-IN-3		✔						99%+
Phen-DC3 Trifluoromethanesulfonate		✔						98%
Favipiravir			✔					97%
Suramin sodium salt			++ RdRp, IC50: 0.26 μM					99%+
Clofarabine				++ Ribonucleotide reductase, IC50: 65 nM				99%+
Didox				✔				99%+
(E)-3-AP				✔				99%+
Halofuginone					+++ prolyl-tRNA synthetase, Ki: 18.3nM			99%+
BC-LI-0186					+++ Leucyl-tRNA synthetase, IC50: 46.11 nM Leucyl-tRNA synthetase, Kd: 42.1 nM			98%
SU056						+ YB-1, IC50: 1.73 μM		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	AC ↓ ↑	EPAC1 ↓ ↑	EPAC2 ↓ ↑	纯度
Bithionol	+ sAC, IC50: 4.0 μM			99%+
SQ22536	✔			99%+
ESI-09		++ EPAC1, IC50: 3.2 μM	+++ EPAC2, IC50: 1.4 μM	99%+
HJC0350			+++ EPAC2, IC50: 0.3 μM	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	NF-κB ↓ ↑	其他靶点	纯度
Pyrrolidinedithiocarbamate ammonium	✔		98%
QNZ	++++ NF-κB, IC50: 11 nM		99%+
Sodium 4-Aminosalicylate Dihydrate	✔		99%+
Sodium Salicylate	✔		99%+
Parthenolide	✔	p53	97% HPLC
JSH-23	+ NF-κB, IC50: 7.1 μM		98%
Phenethyl caffeate	✔		99%+
Andrographolide	✔		99%+
Curcumin	✔	Nrf2,HDAC	98%
SC75741	+++ NF-κB, EC50: 200 nM		99%+
CBL0137 HCl	++ NF-κB, EC50: 0.47 μM	p53	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Resveratrol 生物活性

靶点

SIRT1
JNK1

JNK1, IC50:50 μM

描述

Resveratrol inhibits the activity of Cyclooxygenase, lipooxygenase, PKCs and p56, ERK1, JNK1, p38, IKK β, Src, STAT3, Ribonucleotide Reductase, DNA polymerases α and δ, PKD, PKC α, Quinone reductase 2, and Aromatase with IC50 of 0.035-60 μM. Resveratrol is also an activator of Adenylyl cyclase and AMPK with EC50 of 0.8 μM and 50 μM, respectively. The roles of Resveratrol as inhibitor or activator enable its effects on decreasing cell inflammatory associated behaviors, growth inhibition and induction of apoptosis in cancer cells, reversal of endothelin-1 stimulated cell responses, inhibition of phorbol ester-induced expression of COX-2, inhibition of DNA synthesis in cell, resistance to menadione-induced cell death, and improvement of cell mitochondrial function and glucose/lipid metabolism.
Resveratrol is also an activator of sirtuins. Resveratrol lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD, and increases cell survival by stimulating SIRT1-dependent deacetylation of p53. In yeast, Resveratrol mimics calorie restriction by stimulating Sir2, increasing DNA stability and extending lifespan.
Resveratrol is effective at protecting isolated rat hearts against ischemia/reperfusion injury via its antioxidant activity, with improved recovery of developed pressure and aortic flow, reduction of malondialdehyde concentrations and reduction of infarct size.^[1][2]

Resveratrol 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
HEK293 cells		Function assay	48 h	Inhibition of TNF-alpha-induced NF-kappaB activity expressed in HEK293 cells after 48 hrs by luciferase reporter gene assay, IC50=0.173 μM	20527891
HEK293T cells		Function assay		Inhibition of TNF-alpha-induced NF-kappaB activation in HEK293T cells, IC50=20 μM	17125270
human 293 cells		Function assay	24 h	Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay, IC50=16.1 μM	18487053
human A549 cells		Proliferation assay	48 h	Antiproliferative activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay, IC50=4.47e-05	21851083

Resveratrol 动物研究

Dose	Rat: 10 mg/kg, 100 mg/kg^[7] (i.g.) Mice: 1 mg/kg - 5 mg/kg^[7] (i.p.), 150 mg/kg^[7] (p.o.) Nude Mice: 25 mg/kg^[7] (i.p.)
Administration	i.g., p.o., i.p.

Resveratrol 参考文献

[1]Pirola L, Frojdo S. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60(5):323-32.

[2]Howitz KT, Bitterman KJ, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003 Sep 11;425(6954):191-6.

[3]Zunino SJ, Storms DH, et al. Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. Int J Oncol. 2012;40(4):1277-84.

[4]Thirunavukkarasu M, Penumathsa SV, et al. Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med. 2007;43(5):720-9.

[5]Harper CE, Cook LM, et al. Genistein and resveratrol, alone and in combination, suppress prostate cancer in SV-40 tag rats. Prostate. 2009;69(15):1668-82.

[6]Singh M, Parent S, et al. Resveratrol modulates the expression of PTGS2 and cellular proliferation in the normal rat endometrium in an AKT-dependent manner. Biol Reprod. 2011;84(5):1045-52.

Resveratrol 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.38mL

0.88mL

0.44mL

21.91mL

4.38mL

2.19mL

43.81mL

8.76mL

4.38mL

Resveratrol 技术信息

CAS号	501-36-0
分子式	C₁₄H₁₂O₃
分子量	228.24

别名	trans-Resveratrol;SRT501;Vineatrol 20M.;Resvida;CA1201;RM1812;(E)-Resveratrol
运输	蓝冰

存储条件

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(460.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 45 mg/mL(197.16 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇

动物实验配方

5% DMSO+30% PEG 300+water 15 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

HEK293 cells		Function assay	48 h	Inhibition of TNF-alpha-induced NF-kappaB activity expressed in HEK293 cells after 48 hrs by luciferase reporter gene assay, IC50=0.173 μM	20527891
HEK293T cells		Function assay		Inhibition of TNF-alpha-induced NF-kappaB activation in HEK293T cells, IC50=20 μM	17125270
human 293 cells		Function assay	24 h	Inhibition of TNFalpha induced NF-kappaB activation in human 293 cells after 24 hrs by luciferase reporter gene assay, IC50=16.1 μM	18487053
human A549 cells		Proliferation assay	48 h	Antiproliferative activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay, IC50=4.47e-05	21851083
human Caco-2 cells		Cytotoxic assay	3 days	Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay	20627379
human CCD-18Co cells	1 μM	Function assay	18 h	Antiinflammatory activity in human CCD-18Co cells assessed inhibition of IL1beta-induced PGE2 production at 1 uM after 18 hrs	20866032
human COLO205 cells		Proliferation assay		Antiproliferative activity against human COLO205 cells by MTT assay , IC50=23.5 μM	25455486
human H460 cells		Proliferation assay	72 h	Antiproliferative activity against human H460 cells after 72 hrs, IC50=12.9 μM	20409723
human H460 cells	20 μM	Function assay	24 h	Cell cycle arrest in human H460 cells assessed as accumulation at G2/M phase at 20 uM after 24 hrs by propidium iodide staining-based flow cytometry	20409723
human HeLa cells		Proliferation assay	48 h	Antiproliferative activity against human HeLa cells assessed as cell viability after 48 hrs by SRB assay, IC50=2.25e-05 μM	21851083
human HeLa cells		Function assay	30 mins	Inhibition of Hedgehog signaling pathway in human HeLa cells assessed as inhibition of PMA induced luciferase treated 30 mins before induction	23547843
human HL60 cell line		Proliferation assay		Antiproliferative activity against human HL60 cell line, IC50=5 μM	16686543
human HT144 cells		Proliferation assay	5 days	Antiproliferative activity against human HT144 cells after 5 days by acid phosphatase assay， IC50=40 μM	19481462
human HT-29 cells		Cytotoxic assay	3 days	Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay, IC50=45.3 μM	20627379
human Huh7.5.1 cells		Cytotoxic assay	72 h	Cytotoxicity against human Huh7.5.1 cells after 72 hrs, IC50=10.6 μM	23673225
human K562 cell line		Proliferation assay		Antiproliferative activity against human K562 cell line expressing Bcr-Abl, IC50=28 μM	16686543
human LS 174T cells	10 μM	Cytotoxic assay	4 days	Cytotoxicity against human LS 174T cells at 10 uM for 4 days by vi-cell cell viability analysis	21291235
human MCF7 cells		Proliferation assay	48 h	Antiproliferative activity against human MCF7 cells assessed as cell viability after 48 hrs by SRB assay, IC50=7.91e-05	21851083
human MCF7 cells		Function assay	6 h	Inhibition of phorbol ester-induced ornithine decarboxylase in human MCF7 cells after 6 hrs, IC50=19 μM	10075742
human MDA468 cells		Proliferation assay		Antiproliferative activity against human MDA468 cells by MTT assay, IC50=45.2 μM	25455486
human MDA-MB-231 cells		Function assay	6 days	Antitumor activity against human MDA-MB-231 cells after 6 days by SRB assay, IC50=20.5 μM	20728369
human MG63 cells	0.1 to 10 uM	Function assay	7 days	Increase in ALP activity in human MG63 cells at 0.1 to 10 uM after 7 days	17513867
human MGC803 cells		Proliferation assay		Antiproliferative activity against human MGC803 cells by MTT assay, IC50=42 μM	25455486
human SH-SY5Y cells		Function assay		Neuroprotective activity in human SH-SY5Y cells assessed as inhibition H2O2-induced reduction of cell viability at 10 uM after 24 hrs by phase-contrast micrograph analysis	24269515
human SK-MEL cells		Cytotoxic assay	48 h	Cytotoxicity against human SK-MEL cells assessed as growth inhibition measured after 48 hrs by XTT assay， IC50=47.3 μM	23547843
human SK-N-SH cells		Proliferation assay	48 h	Antiproliferative activity against human SK-N-SH cells assessed as cell viability after 48 hrs by SRB assay, IC50=4.03e-05	21851083
human SW480 cells		Proliferation assay	48 h	Antiproliferative activity against human SW480 cells assessed as cell viability using propidium iodide staining after 48 hrs, IC50=20 μM	20395019
human SW480 cells	10 μM	Cytotoxic assay	2 days	Cytotoxicity against human SW480 cells at 10 uM for 2 days by vi-cell cell viability analysis	21291235
human T47D cells	1 μM	Proliferation assay		Antiproliferative activity against human T47D cells at 1 uM by flow cytometry	17513867
human THP1 cells	100 μM	Function assay	1 h	Inhibition of FSL1-induced upregulation of dectin-1 mRNA expression in in human THP1 cells at 100 uM after 1 hr by RT-PCR	17938187
human U2OS cells	100 μM	Function assay		Activation of SIRT1 in human U2OS cells assessed as decrease in p53 deacetylation level at 100 uM	18046409
human U937 cells		Cytotoxic assay	48 h	Cytotoxicity against human U937 cells after 48 hrs by WST1 test, IC50=17 μM	16252924
HUVEC	100 μM	Function assay	1 day	Induction of mitochondrial biogenesis in H2O2-induced HUVEC at 100 umol/L pretreated for 1 day followed by compound washout and H2O2-treatment measured after 10 days by MitoTracker Red staining-based assay	23859249
MCF7 cells		Cytotoxic assay	72 h	Cytotoxicity against human estrogen receptor positive MCF7 cells after 72 hrs by MTT assay， IC50=28.07 μM	23860590
mouse 3T3L1 cells		Function assay	7 days	Antiadipogenic activity against mouse 3T3L1 cells assessed as inhibition of differentiation after 7 days by oil-red O staining, IC50=31.4 μM	19757853
mouse C2C12 cells	50 μM	Function assay	16 h	Increase in mitochondrial function in mouse C2C12 cells assessed as enhancement of mitochondrial density at 50 uM after 16 hrs by green FM dye straining-based fluorescence assay	19663498
mouse Hepa1clc7 cells		Cytotoxic assay	72 h	Cytotoxicity against mouse Hepa1clc7 cells after 72 hrs, IC50=11 μM	10075742
mouse HT22 cells		Function assay	24 h	Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxytosis after 24 hrs by MTT assay	21129978
mouse MC3T3-E1 cells	1 μM	Apoptosis assay	48 h	Inhibition of antiapoptotic activity in mouse MC3T3-E1 cells at 1 uM after 48 hrs in presence of BMP2-specific neutralizing antibody	17513867
mouse NIH/3T3 cells		Cytotoxic assay	96 h	Cytotoxicity against mouse NIH/3T3 cells after 96 hrs by SRB assay, IC50=24.22 μM	22749392
RAW264.7 cells		Function assay		Inhibitory effect on PGE-2 production in LPS-stimulated RAW264.7 cells, IC50=4 μM	15080988
SKBR3 cells		Cytotoxic assay	72 h	Cytotoxicity against human estrogen receptor negative SKBR3 cells after 72 hrs by MTT assay， IC50=41.42 μM	23860590

白藜芦醇 /Resveratrol 98%

Resveratrol 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Resveratrol 质控信息

Resveratrol 生物活性

Resveratrol 细胞研究

Resveratrol 动物研究

Resveratrol 参考文献

Resveratrol 实验方案

Resveratrol 技术信息

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白藜芦醇 /Resveratrol 98%

Resveratrol 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Resveratrol 质控信息

Resveratrol 生物活性

Resveratrol 细胞研究

Resveratrol 动物研究

Resveratrol 参考文献

Resveratrol 实验方案

Resveratrol 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Resveratrol 纯度/质量文件产品仅供科研