硫氯酚 /Bithionol
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货号：A138799
同义名：
硫双二氯酚
/ CP 3438;Actamer
Bithionol is an anti-parasitic drug and can be used to inhibit solid tumor growth in several preclinical cancer models.
Bithionol 化学结构
Bithionol 3D分子结构
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Bithionol 纯度/质量文件 产品仅供科研
货号：A138799
标准纯度：
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Bithionol 质控信息
Bithionol 生物活性
靶点
描述
Bithionol is a potent sAC-specific inhibitor with IC50 value of 4μM[3] [4]
作用机制
Bithionol binds to the sAC-specific, allosteric binding site for the physiological activator. It induces rearrangements of substrate binding residues and of Arg176, a trigger between the active site and allosteric site.[3]
Bithionol 动物研究
Dose
Horse: 5 mg/kg, 10 mg/kgEvaluation of Anthelmintic Efficacy of Bithionol Paste against Tapeworms Naturally Infected in Horses, by Fecal Examination and Necropsy[3] [4]
Administration
p.o.
Bithionol 参考文献
[1] Kleinboelting S, Ramos-Espiritu L, et al. Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J Biol Chem. 2016 Apr 29;291(18):9776-84.
[2] Jakobsen E, Lange SC, et al. The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms. Biochem Pharmacol. 2018 Sep;155:92-101.
[3] Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, Glickman JF, Levin LR, Buck J, Steegborn C. Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site. J Biol Chem. 2016 Apr 29;291(18):9776-84. doi: 10.1074/jbc.M115.708255. Epub 2016 Mar 9. PMID: 26961873; PMCID: PMC4850313.
[4] Jakobsen E, Lange SC, Andersen JV, Desler C, Kihl HF, Hohnholt MC, Stridh MH, Rasmussen LJ, Waagepetersen HS, Bak LK. The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms. Biochem Pharmacol. 2018 Sep;155:92-101. doi: 10.1016/j.bcp.2018.06.023. Epub 2018 Jun 22. PMID: 29940175.
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Bithionol 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.81mL
0.56mL
0.28mL
14.04mL
2.81mL
1.40mL
28.09mL
5.62mL
2.81mL
Bithionol 技术信息
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