LRE1是一种特异性可溶性腺苷酸环化酶的变构抑制剂，用于调控细胞信号传导途径，广泛应用于分子生物学研究。

TDI-10229是一种有效的口服腺苷酸环化酶 (sAC) 抑制剂，IC₅₀ 值为 195 nM，具有良好的生物活性和药代动力学特性，适用于体内工具化合物和代谢研究。

NKY80是一种高效、选择性、非竞争性的 V 型腺苷酸环化酶 (AC) 抑制剂。它对 V 型 AC 的 IC₅₀ 为 8.3 μM，对 III 型和 II 型的抑制作用较弱。该化合物可调节心脏和肺组织中的 AC 活性，适用于心血管及呼吸系统疾病研究。

I942是首个非环核苷酸 (NCN) EPAC1 激动剂，通过调节促炎细胞因子信号传导，减少心血管疾病相关的炎症，具有抗心血管疾病的研究潜力。

KH7是可溶性腺苷酸环化酶（sAC）的特异性抑制剂，在细胞中对重组sACt蛋白（人类和其他物种）的IC50为3-10 μM。KH7也是cAMP的抑制剂。

SQ22536是一种有效的腺苷酸环化酶（AC）抑制剂。

2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart .

LY367385 HCl是一种高效且选择性的 mGluR1a 拮抗剂，其对喹啉诱导的磷酸肌醇水解的 IC50 为 8.8 μM，而对 mGlu5a 的 IC50 大于 100 μM。LY367385 hydrochloride 具有神经保护、抗惊厥和抗癫痫作用。

2′,3′-Dideoxyadenosine is a nucleoside analog of deoxyadenosine. It inhibits adenylyl cyclase and may play a key role in the inhibition of tumor progression. It is a potent inhibitor of reverse transcriptase enzyme of HIV.

Resveratrol is one of the numerous polyphenolic compounds found in several vegetal sources, has a wide spectrum of targets with IC50 of 0.8, 1, 3.3 and 5 μM for Adenylyl cyclase, IKKβ, DNA polymerase α and δ, respectively.

Bithionol is an anti-parasitic drug and can be used to inhibit solid tumor growth in several preclinical cancer models.

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types with binding (IC50=41 nM) to and activation (EC50=0.5 μM) of type I adenylyl cyclase. It is commonly used to raise levels of cAMP in the research of cell physiology.

PACAP 1-38 is a potent PACAP receptor agonist with IC50s of 4 nM, 2 nM, and 1 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 respectively.