HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM.
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HJC0350 is a selective EPAC2 antagonist with IC50 value of 0.3μM for competing with 8-NBD-cAMP binding of EPAC2[3]. HJC0350 at 0.3μM represented inhibitory effects of the insulinotropic function of AWRK6 in the mouse pancreatic β cell line Min6 cells[4].
作用机制
HJC0350 inhibited EPAC2 in a competitive manner.[3]
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