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重楼皂苷I /Polyphyllin I {[allProObj[0].p_purity_real_show]}

货号：A563817 同义名： 重楼皂甙 / (+)-Polyphyllin D

Polyphyllin D, a natural product isolated and purified from the rhizomes of Paris yunnanensis Franch. with anti-angiongenic, toxic and anti-cancer effects, induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C and cleaved-caspase-3 levels.

Polyphyllin I 化学结构
CAS号：50773-41-6

Polyphyllin I 3D分子结构
CAS号：50773-41-6

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Polyphyllin I 纯度/质量文件产品仅供科研

货号：A563817 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

Akt 亚型比较
JNK 亚型比较
mTOR 亚型比较
自噬亚型比较

产品名称	Akt ↓ ↑	Akt1 ↓ ↑	Akt2 ↓ ↑	Akt3 ↓ ↑	其他靶点	纯度
Honokiol	✔				MEK	{[allProObj[0].p_purity_real_show]}
PF-04691502	++++ P-Akt (T308), IC50: 7.5 nM P-Akt (S473), IC50: 3.8 nM					{[allProObj[0].p_purity_real_show]}
PHT-427	+ Akt, Ki: 2.7 μM					{[allProObj[0].p_purity_real_show]}
Deguelin	✔				PI3K	{[allProObj[0].p_purity_real_show]}
TIC10 isomer	✔				ERK	{[allProObj[0].p_purity_real_show]}
Perifosine	+ Akt, IC50: 4.7 μM					{[allProObj[0].p_purity_real_show]}
Miltefosine	✔				PI3K,PKC	{[allProObj[0].p_purity_real_show]}
Triciribine	+ Akt, IC50: 130 nM					{[allProObj[0].p_purity_real_show]}
Uprosertib		+ Akt1, IC50: 180 nM	+ Akt2, IC50: 328 nM	++ Akt3, IC50: 38 nM		{[allProObj[0].p_purity_real_show]}
Afuresertib		++++ Akt1, Ki: 0.08 nM	++++ Akt2, Ki: 2 nM	++++ Akt3, Ki: 2.6 nM		{[allProObj[0].p_purity_real_show]}
Miransertib		++++ Akt1, IC50: 5 nM	++++ Akt2, IC50: 4.5 nM	++ Akt3, IC50: 16 nM		{[allProObj[0].p_purity_real_show]}
GSK-690693		++++ Akt1, IC50: 2 nM	+++ Akt2, IC50: 13 nM	+++ Akt3, IC50: 9 nM		{[allProObj[0].p_purity_real_show]}
AT7867		++ Akt1, IC50: 32 nM	++ Akt2, IC50: 17 nM	++ Akt3, IC50: 47 nM	PKA	{[allProObj[0].p_purity_real_show]}
AKT inhibitor VIII		++ Akt1, IC50: 58 nM	+ Akt2, IC50: 210 nM	+ Akt3, IC50: 2119 nM		{[allProObj[0].p_purity_real_show]}
MK-2206 2HCl		+++ Akt1, IC50: 8 nM	+++ Akt2, IC50: 12 nM	+ Akt3, IC50: 65 nM		{[allProObj[0].p_purity_real_show]}
Ipatasertib		++++ Akt1, IC50: 5 nM	++ Akt2, IC50: 18 nM	+++ Akt3, IC50: 8 nM		{[allProObj[0].p_purity_real_show]}
AT13148		++ Akt1, IC50: 38 nM	+ Akt2, IC50: 402 nM	++ Akt3, IC50: 50 nM	PKA	{[allProObj[0].p_purity_real_show]}
Capivasertib		++++ Akt1, IC50: 3 nM	+++ Akt2, IC50: 8 nM	+++ Akt3, IC50: 8 nM		{[allProObj[0].p_purity_real_show]}
A-674563 HCl		+++ Akt1, Ki: 11 nM			PKA	{[allProObj[0].p_purity_real_show]}
CCT128930			+++ Akt2, IC50: 6 nM		PKA	{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	JNK ↓ ↑	JNK1 ↓ ↑	JNK2 ↓ ↑	JNK3 ↓ ↑	其他靶点	纯度
Mulberroside A	✔					{[allProObj[0].p_purity_real_show]}
Loureirin B	✔				Potassium Channel,Calcium Channel	{[allProObj[0].p_purity_real_show]}
Ginsenoside Re	✔				NF-κB	{[allProObj[0].p_purity_real_show]}
(+)-(3R,8S)-Falcarindiol	✔				STAT,ERK	{[allProObj[0].p_purity_real_show]}
trans-Zeatin	✔				p38 MAPK,ERK	{[allProObj[0].p_purity_real_show]}
Urolithin B	✔				ERK,NF-κB	{[allProObj[0].p_purity_real_show]}
Cucurbitacin IIb	✔				NF-κB	{[allProObj[0].p_purity_real_show]}
Astragaloside IV	✔				mTOR,Akt,NF-κB	{[allProObj[0].p_purity_real_show]}
NDMC101	✔					{[allProObj[0].p_purity_real_show]}
DB07268		++++ JNK1, IC50: 9 nM				{[allProObj[0].p_purity_real_show]}
SP600125	+ MKK4, IC50: 0.4 μM	+++ JNK1, IC50: 40 nM	+++ JNK2, IC50: 40 nM	+++ JNK3, IC50: 90 nM		{[allProObj[0].p_purity_real_show]}
JNK-IN-7		++++ JNK1, IC50: 1.5 nM	++++ JNK2, IC50: 2 nM	++++ JNK3, IC50: 0.7 nM		{[allProObj[0].p_purity_real_show]}
JNK-IN-8		++++ JNK1, IC50: 4.7 nM	+++ JNK2, IC50: 18.7 nM	++++ JNK3, IC50: 1 nM		{[allProObj[0].p_purity_real_show]}
3,3',5-Triiodo-L-thyronine		++ JNK1, Kd: 240 nM	++ JNK2, Kd: 290 nM	+++ JNK3, Kd: 66 nM		{[allProObj[0].p_purity_real_show]}
IQ-1S free acid		+ JNK1, IC50: 390 nM	++ JNK2, IC50: 360 nM	+++ JNK3, IC50: 87 nM		{[allProObj[0].p_purity_real_show]}
BI-78D3	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM		{[allProObj[0].p_purity_real_show]}
Bentamapimod		+++ JNK1, IC50: 80 nM	+++ JNK2, IC50: 90 nM	++ JNK3, IC50: 230 nM		{[allProObj[0].p_purity_real_show]}
Resveratrol		+ JNK1, IC50: 50 μM				{[allProObj[0].p_purity_real_show]}
Indirubin-3′-oxime		✔				{[allProObj[0].p_purity_real_show]}
SU3327	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM		{[allProObj[0].p_purity_real_show]}
JNK Inhibitor VIII		++++ JNK1, IC50: 45 nM JNK1, Ki: 2 nM	++++ JNK2, Ki: 4 nM JNK2, IC50: 160 nM	+++ JNK3, Ki: 52 nM		{[allProObj[0].p_purity_real_show]}
Doramapimod			✔			{[allProObj[0].p_purity_real_show]}
RPI-1			✔			{[allProObj[0].p_purity_real_show]}
TCS JNK 5a			++ JNK2, pIC50: 6.5	++ JNK3, pIC50: 6.7		{[allProObj[0].p_purity_real_show]}
SP 600125, negative control			+ JNK2, IC50: 18 μM	+ JNK3, IC50: 24 μM		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	mTOR ↓ ↑	mTORC1 ↓ ↑	mTORC2 ↓ ↑	其他靶点	纯度
AZD-8055	++++ mTOR (full length), IC50: 0.8 nM mTOR (truncated), IC50: 0.13 nM				{[allProObj[0].p_purity_real_show]}
Gedatolisib	++++ mTOR, IC50: 1.6 nM				{[allProObj[0].p_purity_real_show]}
GSK1059615	++ mTOR, IC50: 12 nM				{[allProObj[0].p_purity_real_show]}
Vistusertib	+++ mTOR, IC50: 2.8 nM				{[allProObj[0].p_purity_real_show]}
Torin 1	+++ mTOR, IC50: 4.32 nM	+++ mTORC1, IC50: 2 nM	++ mTORC2, IC50: 10 nM	DNA-PK	{[allProObj[0].p_purity_real_show]}
Dactolisib	+++ mTOR (p70S6K), IC50: 6 nM				{[allProObj[0].p_purity_real_show]}
PI-103	+ mTOR, IC50: 30 nM				{[allProObj[0].p_purity_real_show]}
WAY-600	++ mTOR, IC50: 9 nM				{[allProObj[0].p_purity_real_show]}
Voxtalisib	+ mTOR, IC50: 157 nM				{[allProObj[0].p_purity_real_show]}
PF-04691502	++ mTOR, Ki: 16 nM				{[allProObj[0].p_purity_real_show]}
Onatasertib	++ mTOR, IC50: 16 nM			DNA-PK	{[allProObj[0].p_purity_real_show]}
Chrysophanol	✔			EGFR	{[allProObj[0].p_purity_real_show]}
Samotolisib	✔			DNA-PK	{[allProObj[0].p_purity_real_show]}
Torkinib	+++ mTOR, IC50: 8 nM			DNA-PK,PDGFR	{[allProObj[0].p_purity_real_show]}
Everolimus					{[allProObj[0].p_purity_real_show]}
WYE-354	+++ mTOR, IC50: 5 nM				{[allProObj[0].p_purity_real_show]}
Tacrolimus	✔				{[allProObj[0].p_purity_real_show]}
PP121	++ mTOR, IC50: 13 nM			PDGFR,VEGFR	{[allProObj[0].p_purity_real_show]}
Torin 2	++++ mTOR, IC50: 0.25 nM			DNA-PK	{[allProObj[0].p_purity_real_show]}
Rapamycin	++++ mTOR, IC50: ~0.1 nM				{[allProObj[0].p_purity_real_show]}
GDC-0349	+++ mTOR, Ki: 3.8 nM				{[allProObj[0].p_purity_real_show]}
XL388	++ mTOR, IC50: 9.9 nM	+++ mTORC1, IC50: 8 nM	+ mTORC2, IC50: 166 nM		{[allProObj[0].p_purity_real_show]}
WYE-687	+++ mTOR, IC50: 7 nM				{[allProObj[0].p_purity_real_show]}
Apitolisib	+ mTOR, Ki app: 17 nM				{[allProObj[0].p_purity_real_show]}
WYE-132	++++ mTOR, IC50: 0.19 nM				{[allProObj[0].p_purity_real_show]}
Sapanisertib	++++ mTOR, Ki: 1.4 nM				{[allProObj[0].p_purity_real_show]}
BGT226 maleate	✔				{[allProObj[0].p_purity_real_show]}
ETP-46464	++++ mTOR, IC50: 0.6 nM			DNA-PK	{[allProObj[0].p_purity_real_show]}
PI3K-IN-1	+ mTOR, IC50: 157 nM				{[allProObj[0].p_purity_real_show]}
Zotarolimus	+++ FKBP-12, IC50: 2.8 nM				{[allProObj[0].p_purity_real_show]}
OSI-027	+++ mTOR, IC50: 4 nM	+ mTORC1, IC50: 22 nM	+ mTORC2, IC50: 65 nM		{[allProObj[0].p_purity_real_show]}
Ridaforolimus	++++ mTOR, IC50: 0.2 nM				{[allProObj[0].p_purity_real_show]}
Temsirolimus	+ mTOR, IC50: 1.76 μM				{[allProObj[0].p_purity_real_show]}
CZ415	++ mTOR, pIC50: 8.07				{[allProObj[0].p_purity_real_show]}
SF2523	+ mTOR, IC50: 280 nM			DNA-PK	{[allProObj[0].p_purity_real_show]}
KU-0063794		++ mTORC1, IC50: ~10 nM	++ mTORC2, IC50: ~10 nM		{[allProObj[0].p_purity_real_show]}
Omipalisib		++++ mTORC1, Ki: 0.18 nM	++++ mTORC2, Ki: 0.3 nM		{[allProObj[0].p_purity_real_show]}
Palomid 529		✔			{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Autophagy ↓ ↑	其他靶点	纯度
SBI-0206965	+++ ULK2, IC50: 711 nM ULK1, IC50: 108 nM		{[allProObj[0].p_purity_real_show]}
Hydroxychloroquine sulfate	✔		{[allProObj[0].p_purity_real_show]}
Valproic acid sodium	✔	HDAC	{[allProObj[0].p_purity_real_show]}
PFK-015	++ PFKFB3, IC50: 207 nM		{[allProObj[0].p_purity_real_show]}
MRT68921 hydrochloride	++++ ULK2, IC50: 1.1 nM ULK1, IC50: 2.9 nM		{[allProObj[0].p_purity_real_show]}
ROC-325	✔		{[allProObj[0].p_purity_real_show]}
Autophinib	+++ Autophagy, IC50: 40 nM		{[allProObj[0].p_purity_real_show]}
Lys05	✔		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Polyphyllin I 生物活性

描述

Polyphyllin D, a natural product isolated and purified from the rhizomes of Paris yunnanensis Franch. with anti-angiongenic, toxic and anti-cancer effects, induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C and cleaved-caspase-3 levels.

Polyphyllin I 参考文献

[1]Yu Q, Li Q, et al. Polyphyllin D induces apoptosis in U87 human glioma cells through the c-Jun NH2-terminal kinase pathway. J Med Food. 2014 Sep;17(9):1036-42.

[2]Wu L, Li Q, Liu Y. Polyphyllin D induces apoptosis in K562/A02 cells through G2/M phase arrest. J Pharm Pharmacol. 2014 May;66(5):713-21.

Polyphyllin I 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.17mL

0.23mL

0.12mL

5.85mL

1.17mL

0.58mL

11.70mL

2.34mL

1.17mL

Polyphyllin I 技术信息

CAS号	50773-41-6
分子式	C₄₄H₇₀O₁₆
分子量	855.017

别名	重楼皂甙 ;(+)-Polyphyllin D
运输	蓝冰

存储条件

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(122.8 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

重楼皂苷I /Polyphyllin I {[allProObj[0].p_purity_real_show]}

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重楼皂苷I /Polyphyllin I {[allProObj[0].p_purity_real_show]}

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全球学术期刊中引用的产品

Polyphyllin I 质控信息

Polyphyllin I 生物活性

Polyphyllin I 参考文献

Polyphyllin I 实验方案

Polyphyllin I 技术信息

最近浏览的产品

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