JNK-IN-8 | JNK Inhibitor XVI | JNK Inhibitor (GMP) | AmBeed-信号通路专用抑制剂

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JNK-IN-8 {[allProObj[0].p_purity_real_show]}

货号：A206353 同义名： JNK Inhibitor XVI;c-Jun N-terminal Kinase Inhibitor XVI

JNK-IN-8是一种高效的JNK抑制剂，对JNK1、JNK2和JNK3的IC50值分别为4.7 nM、18.7 nM和1 nM。

JNK-IN-8 化学结构
CAS号：1410880-22-6

JNK-IN-8 3D分子结构
CAS号：1410880-22-6

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JNK-IN-8 纯度/质量文件产品仅供科研

货号：A206353 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell, 2024, 101755. Ambeed. [ A399663 ]; • EMBO J., 2024. Ambeed. [ A295334 ]; • JMC, 2024, 67(20): 18265-18289. Ambeed. [ A538667 , A341145 , A117430 , A172297 ]; • JMC, 2024. Ambeed. [ A210558 , A1518164 ]; • Cell Death Discov., 2024, 10, 436. Ambeed. [ A384235 ]; 更多 >

JNK 亚型比较

产品名称	JNK ↓ ↑	JNK1 ↓ ↑	JNK2 ↓ ↑	JNK3 ↓ ↑	其他靶点	纯度
Mulberroside A	✔					99%+
Loureirin B	✔				Potassium Channel,Calcium Channel	99%+
Ginsenoside Re	✔				NF-κB	98%
(+)-(3R,8S)-Falcarindiol	✔				STAT,ERK	99%+
trans-Zeatin	✔				ERK,p38 MAPK	95+%
Urolithin B	✔				NF-κB,ERK	95%
Cucurbitacin IIb	✔				NF-κB	98+%
Astragaloside IV	✔				NF-κB,Akt,mTOR	98%
NDMC101	✔					99%+
DB07268		++++ JNK1, IC50: 9 nM				99%+
SP600125	+ MKK4, IC50: 0.4 μM	+++ JNK1, IC50: 40 nM	+++ JNK2, IC50: 40 nM	+++ JNK3, IC50: 90 nM		98%
JNK-IN-7		++++ JNK1, IC50: 1.5 nM	++++ JNK2, IC50: 2 nM	++++ JNK3, IC50: 0.7 nM		98+%
JNK-IN-8		++++ JNK1, IC50: 4.7 nM	+++ JNK2, IC50: 18.7 nM	++++ JNK3, IC50: 1 nM		99%+
3,3',5-Triiodo-L-thyronine		++ JNK1, Kd: 240 nM	++ JNK2, Kd: 290 nM	+++ JNK3, Kd: 66 nM		98%
IQ-1S free acid		+ JNK1, IC50: 390 nM	++ JNK2, IC50: 360 nM	+++ JNK3, IC50: 87 nM		98%
BI-78D3	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM		99%+
Bentamapimod		+++ JNK1, IC50: 80 nM	+++ JNK2, IC50: 90 nM	++ JNK3, IC50: 230 nM		98%
Resveratrol		+ JNK1, IC50: 50 μM				98%
Indirubin-3′-oxime		✔				99%+
SU3327	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM		99%+
JNK Inhibitor VIII		++++ JNK1, Ki: 2 nM JNK1, IC50: 45 nM	++++ JNK2, IC50: 160 nM JNK2, Ki: 4 nM	+++ JNK3, Ki: 52 nM		98%
Doramapimod			✔			99%+
RPI-1			✔			97%
TCS JNK 5a			++ JNK2, pIC50: 6.5	++ JNK3, pIC50: 6.7		98%
SP 600125, negative control			+ JNK2, IC50: 18 μM	+ JNK3, IC50: 24 μM		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

JNK-IN-8 生物活性

靶点	JNK1 JNK1, IC50:4.7 nM JNK2 JNK2, IC50:18.7 nM JNK3 JNK3, IC50:1 nM
描述	c-Jun N-terminal kinases (JNK1/2/3) are key enzymes in the inflammatory signaling network. JNK-IN-8 is a covalent JNK inhibitor with IC50 values of 4.67, 18.7, and 0.98 nM for JNK1, JNK2, and JNK3, respectively. The EC50 values of JNK-IN-8 for the inhibition of c-Jun phosphorylation in Hela and A375 cells are 486 and 338 nM, respectively. JNK-IN-8 possessed a selective S (10) score of 0.031^[3]. In P411-T1 patient-derived xenograft-derived cells, treatment with 1μM JNK-IN-8 for 24 h led to a significant decrease in p-JUN. JNK-IN-8 at 1 μM also enhanced the inhibitory effect of FOLFOX chemotherapy on cell growth and reversed FOLFOX-induced JUN activation in P441-T1, P442-T1, CFPAC-1, and MIA PaCa-2 cells. In mice bearing pancreatic ductal adenocarcinoma tumors, JNK-IN-8 (30 mg/kg, 2×/week) enhanced the efficacy of FOLFOX chemotherapy on tumor growth^[4].
作用机制	JNK-IN-8 inhibits the kinase activity of JNK through the medication of a conserved cysteine in its ATP-binding motif^[3].

JNK-IN-8 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
human A375 cells		Function assay	1 h	Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation, IC50=0.338 μM	25415535
human HeLa cells		Function assay	1 h	Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation, IC50=0.486 μM	25415535

JNK-IN-8 参考文献

[1]19(1):140-154. doi:10.1016/j.chembiol.2011.11.010

[2]5(8):e129905. doi:10.1172/jci.insight.129905

JNK-IN-8 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.85mL

1.97mL

0.99mL

19.70mL

3.94mL

1.97mL

JNK-IN-8 技术信息

CAS号	1410880-22-6
分子式	C₂₉H₂₉N₇O₂
分子量	507.586

别名	JNK Inhibitor XVI;c-Jun N-terminal Kinase Inhibitor XVI
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C

溶解度

DMSO: 35 mg/mL(68.95 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

2% DMSO+30% PEG 300+5% Tween 80+water 10 mg/mL

JNK-IN-8 {[allProObj[0].p_purity_real_show]}

JNK-IN-8 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

JNK-IN-8 质控信息

JNK-IN-8 生物活性

JNK-IN-8 细胞研究

JNK-IN-8 参考文献

JNK-IN-8 实验方案

JNK-IN-8 技术信息

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JNK1	JNK1, IC50:4.7 nM
JNK2	JNK2, IC50:18.7 nM
JNK3	JNK3, IC50:1 nM

JNK-IN-8 {[allProObj[0].p_purity_real_show]}

JNK-IN-8 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

JNK-IN-8 质控信息

JNK-IN-8 生物活性

JNK-IN-8 细胞研究

JNK-IN-8 参考文献

JNK-IN-8 实验方案

JNK-IN-8 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

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JNK-IN-8 纯度/质量文件产品仅供科研