PP121 | mTOR Inhibitor | AmBeed-信号通路专用抑制剂

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PP121 {[allProObj[0].p_purity_real_show]}

货号：A986976

PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.

PP121 化学结构
CAS号：1092788-83-4

PP121 3D分子结构
CAS号：1092788-83-4

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PP121 纯度/质量文件产品仅供科研

货号：A986976 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

mTOR 亚型比较
PDGFR 亚型比较
VEGFR 亚型比较

产品名称	mTOR ↓ ↑	mTORC1 ↓ ↑	mTORC2 ↓ ↑	其他靶点	纯度
AZD-8055	++++ mTOR (truncated), IC50: 0.13 nM mTOR (full length), IC50: 0.8 nM				{[allProObj[0].p_purity_real_show]}
Gedatolisib	++++ mTOR, IC50: 1.6 nM				{[allProObj[0].p_purity_real_show]}
GSK1059615	++ mTOR, IC50: 12 nM				{[allProObj[0].p_purity_real_show]}
Vistusertib	+++ mTOR, IC50: 2.8 nM				{[allProObj[0].p_purity_real_show]}
Torin 1	+++ mTOR, IC50: 4.32 nM	+++ mTORC1, IC50: 2 nM	++ mTORC2, IC50: 10 nM	DNA-PK	{[allProObj[0].p_purity_real_show]}
Dactolisib	+++ mTOR (p70S6K), IC50: 6 nM				{[allProObj[0].p_purity_real_show]}
PI-103	+ mTOR, IC50: 30 nM				{[allProObj[0].p_purity_real_show]}
WAY-600	++ mTOR, IC50: 9 nM				{[allProObj[0].p_purity_real_show]}
Voxtalisib	+ mTOR, IC50: 157 nM				{[allProObj[0].p_purity_real_show]}
PF-04691502	++ mTOR, Ki: 16 nM				{[allProObj[0].p_purity_real_show]}
Onatasertib	++ mTOR, IC50: 16 nM			DNA-PK	{[allProObj[0].p_purity_real_show]}
Chrysophanol	✔			EGFR	{[allProObj[0].p_purity_real_show]}
Samotolisib	✔			DNA-PK	{[allProObj[0].p_purity_real_show]}
Torkinib	+++ mTOR, IC50: 8 nM			PDGFR,DNA-PK	{[allProObj[0].p_purity_real_show]}
Everolimus					{[allProObj[0].p_purity_real_show]}
WYE-354	+++ mTOR, IC50: 5 nM				{[allProObj[0].p_purity_real_show]}
Tacrolimus	✔				{[allProObj[0].p_purity_real_show]}
PP121	++ mTOR, IC50: 13 nM			PDGFR,VEGFR	{[allProObj[0].p_purity_real_show]}
Torin 2	++++ mTOR, IC50: 0.25 nM			DNA-PK	{[allProObj[0].p_purity_real_show]}
Rapamycin	++++ mTOR, IC50: ~0.1 nM				{[allProObj[0].p_purity_real_show]}
GDC-0349	+++ mTOR, Ki: 3.8 nM				{[allProObj[0].p_purity_real_show]}
XL388	++ mTOR, IC50: 9.9 nM	+++ mTORC1, IC50: 8 nM	+ mTORC2, IC50: 166 nM		{[allProObj[0].p_purity_real_show]}
WYE-687	+++ mTOR, IC50: 7 nM				{[allProObj[0].p_purity_real_show]}
Apitolisib	+ mTOR, Ki app: 17 nM				{[allProObj[0].p_purity_real_show]}
WYE-132	++++ mTOR, IC50: 0.19 nM				{[allProObj[0].p_purity_real_show]}
Sapanisertib	++++ mTOR, Ki: 1.4 nM				{[allProObj[0].p_purity_real_show]}
BGT226 maleate	✔				{[allProObj[0].p_purity_real_show]}
ETP-46464	++++ mTOR, IC50: 0.6 nM			DNA-PK	{[allProObj[0].p_purity_real_show]}
PI3K-IN-1	+ mTOR, IC50: 157 nM				{[allProObj[0].p_purity_real_show]}
Zotarolimus	+++ FKBP-12, IC50: 2.8 nM				{[allProObj[0].p_purity_real_show]}
OSI-027	+++ mTOR, IC50: 4 nM	+ mTORC1, IC50: 22 nM	+ mTORC2, IC50: 65 nM		{[allProObj[0].p_purity_real_show]}
Ridaforolimus	++++ mTOR, IC50: 0.2 nM				{[allProObj[0].p_purity_real_show]}
Temsirolimus	+ mTOR, IC50: 1.76 μM				{[allProObj[0].p_purity_real_show]}
CZ415	++ mTOR, pIC50: 8.07				{[allProObj[0].p_purity_real_show]}
SF2523	+ mTOR, IC50: 280 nM			DNA-PK	{[allProObj[0].p_purity_real_show]}
KU-0063794		++ mTORC1, IC50: ~10 nM	++ mTORC2, IC50: ~10 nM		{[allProObj[0].p_purity_real_show]}
Omipalisib		++++ mTORC1, Ki: 0.18 nM	++++ mTORC2, Ki: 0.3 nM		{[allProObj[0].p_purity_real_show]}
Palomid 529		✔			{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	PDGFR ↓ ↑	PDGFRα ↓ ↑	PDGFRβ ↓ ↑	其他靶点	纯度
Tyrphostin A9	+ PDGFR, IC50: 0.5 μM			EGFR	{[allProObj[0].p_purity_real_show]}
Tyrphostin AG1296					{[allProObj[0].p_purity_real_show]}
Motesanib Diphosphate	++ PDGFR, IC50: 84 nM				{[allProObj[0].p_purity_real_show]}
Pazopanib	++ PDGFR, IC50: 84 nM				{[allProObj[0].p_purity_real_show]}
Imatinib	+ PDGFR, IC50: 100 nM			c-Kit	{[allProObj[0].p_purity_real_show]}
Imatinib Mesylate	+ PDGFR, IC50: 100 nM			c-Kit	{[allProObj[0].p_purity_real_show]}
Sennoside B	✔				{[allProObj[0].p_purity_real_show]}
PP121	++++ PDGFR, IC50: 2 nM			mTOR,VEGFR	{[allProObj[0].p_purity_real_show]}
Crenolanib		++++ PDGFRα, Kd: 2.1 nM	++++ PDGFRβ, Kd: 3.2 nM		{[allProObj[0].p_purity_real_show]}
Masitinib		+ PDGFRα, IC50: 540 nM	+ PDGFRβ, IC50: 800 nM		{[allProObj[0].p_purity_real_show]}
Ki8751		++ PDGFRα, IC50: 67 nM		c-Kit	{[allProObj[0].p_purity_real_show]}
Tivozanib		++ PDGFRα, IC50: 40 nM	++ PDGFRβ, IC50: 49 nM		{[allProObj[0].p_purity_real_show]}
Ponatinib		++++ PDGFRα, IC50: 1.1 nM			{[allProObj[0].p_purity_real_show]}
Amuvatinib		++ PDGFRα (V561D), IC50: 40 nM			{[allProObj[0].p_purity_real_show]}
Axitinib		+++ PDGFRα, IC50: 5.0 nM	++++ PDGFRβ, IC50: 1.6 nM		{[allProObj[0].p_purity_real_show]}
CP-673451		+++ PDGFRα, IC50: 10 nM	++++ PDGFRβ, IC50: 1 nM		{[allProObj[0].p_purity_real_show]}
Telatinib		+++ PDGFRα, IC50: 15 nM		c-Kit	{[allProObj[0].p_purity_real_show]}
Nintedanib		++ PDGFRα, IC50: 59 nM	++ PDGFRβ, IC50: 65 nM		{[allProObj[0].p_purity_real_show]}
Avapritinib		++++ PDGFRα (D842V), IC50: 0.5 nM			{[allProObj[0].p_purity_real_show]}
MK-2461			+++ PDGFRβ, IC50: 22 nM		{[allProObj[0].p_purity_real_show]}
Lactate			+++ PDGFRβ, IC50: 27 nM	FLT3,c-Kit	{[allProObj[0].p_purity_real_show]}
Linifanib			++ PDGFRβ, IC50: 66 nM		{[allProObj[0].p_purity_real_show]}
AZD2932			+++ PDGFRβ, IC50: 4 nM	c-Kit	{[allProObj[0].p_purity_real_show]}
Dovitinib			+++ PDGFRβ, IC50: 27 nM	FLT3,c-Kit	{[allProObj[0].p_purity_real_show]}
Sorafenib			++ PDGFRβ, IC50: 57 nM mPDGFRβ, IC50: 57 nM		{[allProObj[0].p_purity_real_show]}
Sunitinib			++++ PDGFRβ , IC50: 2 nM	FLT3	{[allProObj[0].p_purity_real_show]}
Orantinib			+++ PDGFRβ, Ki: 8 nM		{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	VEGFR1 ↓ ↑	VEGFR2 ↓ ↑	VEGFR3 ↓ ↑	其他靶点	纯度
Motesanib Diphosphate	++++ VEGFR1, IC50: 2 nM	++++ VEGFR2/Flk1, IC50: 3 nM VEGFR2, IC50: 3 nM	+++ VEGFR3, IC50: 6 nM	PDGFR,RET	{[allProObj[0].p_purity_real_show]}
Tivozanib	++ VEGFR1, IC50: 30 nM	+++ VEGFR2, IC50: 6.5 nM	++ VEGFR3, IC50: 15 nM		{[allProObj[0].p_purity_real_show]}
Brivanib	+ VEGFR1, IC50: 380 nM	++ VEGFR2, IC50: 25 nM Flk1, IC50: 25 nM			{[allProObj[0].p_purity_real_show]}
Regorafenib	+++ VEGFR1, IC50: 13 nM	+++ VEGFR2, IC50: 4.2 nM	+ VEGFR3, IC50: 46 nM	RET	{[allProObj[0].p_purity_real_show]}
Pazopanib	+++ VEGFR1, IC50: 10 nM	++ VEGFR2, IC50: 30 nM	+ VEGFR3, IC50: 47 nM	PDGFR,FGFR,c-Kit	{[allProObj[0].p_purity_real_show]}
Sitravatinib	+++ VEGFR1 (FLT1), IC50: 6 nM	+++ VEGFR2 (KDR), IC50: 5 nM	++++ VEGFR3 (FLT4), IC50: 2 nM		{[allProObj[0].p_purity_real_show]}
Foretinib	+++ VEGFR1/FLT1, IC50: 6.8 nM	++++ KDR, IC50: 0.86 nM	++++ VEGFR3/FLT4, IC50: 2.8 nM	Tie-2	{[allProObj[0].p_purity_real_show]}
MGCD-265 analog	++++ VEGFR1, IC50: 3 nM	++++ VEGFR2, IC50: 3 nM	++++ VEGFR3, IC50: 4 nM	Tie-2	{[allProObj[0].p_purity_real_show]}
Lactate	+++ VEGFR1/FLT1, IC50: 10 nM	+++ VEGFR2/Flk1, IC50: 13 nM	+++ VEGFR3/FLT4, IC50: 8 nM	FLT3,c-Kit	{[allProObj[0].p_purity_real_show]}
AEE788	+ FLT1, IC50: 59 nM	+ KDR, IC50: 77 nM		EGFR	{[allProObj[0].p_purity_real_show]}
Linifanib	++++ VEGFR1/FLT1, IC50: 3 nM	++++ VEGFR2/KDR, IC50: 4 nM	+ VEGFR3/FLT4, IC50: 190 nM	FLT3	{[allProObj[0].p_purity_real_show]}
Vatalanib 2HCl	+ VEGFR1/FLT1, IC50: 77 nM	++ VEGFR2/Flk1, IC50: 270 nM VEGFR2/KDR, IC50: 37 nM	+ VEGFR3/FLT4, IC50: 660 nM	c-Fms,c-Kit	{[allProObj[0].p_purity_real_show]}
Axitinib	++++ VEGFR1/FLT1, IC50: 0.1 nM	++++ VEGFR2/Flk1, IC50: 0.18 nM VEGFR2/KDR, IC50: 0.2 nM			{[allProObj[0].p_purity_real_show]}
Dovitinib	+++ VEGFR1/FLT1, IC50: 10 nM	+++ VEGFR2/Flk1, IC50: 13 nM	+++ VEGFR3/FLT4, IC50: 8 nM	FLT3,c-Kit	{[allProObj[0].p_purity_real_show]}
ZM 306416	+ VEGFR1, IC50: 0.33 μM			Src	{[allProObj[0].p_purity_real_show]}
KRN-633	+ VEGFR1, IC50: 170 nM	+ VEGFR2, IC50: 160 nM	+ VEGFR3, IC50: 125 nM	BTK,c-Kit	{[allProObj[0].p_purity_real_show]}
OSI-930	+++ FLT1, IC50: 8 nM	+++ KDR, IC50: 9 nM			{[allProObj[0].p_purity_real_show]}
Lenvatinib	++ VEGFR1/FLT1, IC50: 22 nM	++++ VEGFR2/KDR, IC50: 4.0 nM	+++ VEGFR3/FLT4, IC50: 5.2 nM		{[allProObj[0].p_purity_real_show]}
NVP-BAW2881	+ hVEGFR1, IC50: 820 nM	+++ mVEGF2, IC50: 165 nM hVEGFR2, IC50: 9 nM	+ hVEGFR3, IC50: 420 nM		{[allProObj[0].p_purity_real_show]}
Cediranib	+++ VEGFR1/FLT1, IC50: 5 nM	++++ VEGFR2/KDR, IC50: 0.5 nM		c-Kit	{[allProObj[0].p_purity_real_show]}
Nintedanib	++ VEGFR1, IC50: 34 nM	+++ VEGFR2, IC50: 13 nM	+++ VEGFR3, IC50: 13 nM	FLT3	{[allProObj[0].p_purity_real_show]}
BMS-794833		++ VEGFR2, IC50: 15 nM			{[allProObj[0].p_purity_real_show]}
SKLB1002		++ VEGFR2, IC50: 32 nM			{[allProObj[0].p_purity_real_show]}
Cabozantinib S-malate		++++ VEGFR2/KDR, IC50: 0.035 nM			{[allProObj[0].p_purity_real_show]}
Ki8751		++++ VEGFR2, IC50: 0.9 nM		c-Kit	{[allProObj[0].p_purity_real_show]}
SU 5402		++ VEGFR2, IC50: 20 nM			{[allProObj[0].p_purity_real_show]}
Rivoceranib Mesylate		++++ VEGFR2, IC50: 1 nM		RET	{[allProObj[0].p_purity_real_show]}
Ponatinib		++++ VEGFR2, IC50: 1.5 nM			{[allProObj[0].p_purity_real_show]}
LY2874455		+++ VEGFR2, IC50: 7 nM			{[allProObj[0].p_purity_real_show]}
ZM323881 HCl		++++ VEGFR2, IC50: <2 nM			{[allProObj[0].p_purity_real_show]}
AZD2932		+++ VEGFR-2, IC50: 8 nM		c-Kit	{[allProObj[0].p_purity_real_show]}
Cabozantinib		++++ VEGFR2/KDR, IC50: 0.035 nM			{[allProObj[0].p_purity_real_show]}
Sorafenib		++ VEGFR2/Flk1, IC50: 90 nM VEGFR2, IC50: 90 nM			{[allProObj[0].p_purity_real_show]}
CYC-116		++ VEGFR2, Ki: 44 nM		FLT3	{[allProObj[0].p_purity_real_show]}
Golvatinib		++ VEGFR2, IC50: 16 nM			{[allProObj[0].p_purity_real_show]}
Sunitinib		+ VEGFR2 , IC50: 80 nM		FLT3	{[allProObj[0].p_purity_real_show]}
RAF265		++ VEGFR2, EC50: 30 nM			{[allProObj[0].p_purity_real_show]}
PD173074					{[allProObj[0].p_purity_real_show]}
BFH772		++++ VEGFR2, IC50: 3 nM			{[allProObj[0].p_purity_real_show]}
Semaxinib		+ VEGFR2/Flk1, IC50: 1.23 μM			{[allProObj[0].p_purity_real_show]}
Vandetanib		++ VEGFR2, IC50: 40 nM	+ VEGFR3, IC50: 110 nM	EGFR	{[allProObj[0].p_purity_real_show]}
SAR131675			++ VEGFR3, IC50: 23 nM		{[allProObj[0].p_purity_real_show]}
ENMD-2076		+ VEGFR2/KDR, IC50: 58.2 nM	++ VEGFR3/FLT4, IC50: 15.9 nM	FLT3,RET	{[allProObj[0].p_purity_real_show]}
Telatinib		+++ VEGFR2, IC50: 6 nM	++++ VEGFR3, IC50: 4 nM	c-Kit	{[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

PP121 生物活性

靶点	mTOR mTOR, IC50:13 nM DNA-PK DNA-PK, IC50:60 nM PDGFR PDGFR, IC50:2 nM Src Src, IC50:14 nM Abl Abl, IC50:18 nM
描述	PP-121 is a multi-targeted inhibitor of PDGFR, Hck, mTOR, VEGFR2, Src and Abl with IC50 of 2 nM, 8 nM, 10 nM, 12 nM, 14 nM and 18 nM, also inhibits DNA-PK with IC50 of 60 nM.

PP121 参考文献

[1]Peng Y, Zhou Y, et al. The anti-esophageal cancer cell activity by a novel tyrosine/phosphoinositide kinase inhibitor PP121. Biochem Biophys Res Commun. 2015 Sep 11;465(1):137-44.

[2]Apsel B, Blair JA, et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9.

PP121 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.13mL

0.63mL

0.31mL

15.66mL

3.13mL

1.57mL

31.31mL

6.26mL

3.13mL

PP121 技术信息

CAS号	1092788-83-4
分子式	C₁₇H₁₇N₇
分子量	319.364

别名
运输	蓝冰

存储条件

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 18 mg/mL(56.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

PP121 {[allProObj[0].p_purity_real_show]}

PP121 纯度/质量文件产品仅供科研

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mTOR	mTOR, IC50:13 nM
DNA-PK	DNA-PK, IC50:60 nM
PDGFR	PDGFR, IC50:2 nM
Src	Src, IC50:14 nM
Abl	Abl, IC50:18 nM

PP121 {[allProObj[0].p_purity_real_show]}

PP121 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

PP121 质控信息

PP121 生物活性

PP121 参考文献

PP121 实验方案

PP121 技术信息

最近浏览的产品

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PP121 纯度/质量文件产品仅供科研