Honokiol | NSC 293100 | Plant Standard | Akt | AmBeed-信号通路专用抑制剂

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和厚朴酚 /Honokiol {[allProObj[0].p_purity_real_show]}

货号：A146214 同义名： NSC 293100

Honokiol是一种具有强效抗氧化、抗炎、抗血管生成和抗癌活性的双苯植物化学物，通过靶向多种信号分子抑制 Akt 激活，并能轻易穿过血脑屏障。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Honokiol 化学结构
CAS号：35354-74-6

Honokiol 3D分子结构
CAS号：35354-74-6

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Honokiol 纯度/质量文件产品仅供科研

货号：A146214 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Akt 亚型比较

产品名称	Akt ↓ ↑	Akt1 ↓ ↑	Akt2 ↓ ↑	Akt3 ↓ ↑	其他靶点	纯度
Honokiol	✔				MEK	98%
PF-04691502	++++ P-Akt (S473), IC50: 3.8 nM P-Akt (T308), IC50: 7.5 nM					98+%
PHT-427	+ Akt, Ki: 2.7 μM					99%+
Deguelin	✔				PI3K	99%+
TIC10 isomer	✔				ERK	98+%
Perifosine	+ Akt, IC50: 4.7 μM					98%
Miltefosine	✔				PI3K,PKC	98%
Triciribine	+ Akt, IC50: 130 nM					99%+
Uprosertib		+ Akt1, IC50: 180 nM	+ Akt2, IC50: 328 nM	++ Akt3, IC50: 38 nM		99%+
Afuresertib		++++ Akt1, Ki: 0.08 nM	++++ Akt2, Ki: 2 nM	++++ Akt3, Ki: 2.6 nM		99%+
Miransertib		++++ Akt1, IC50: 5 nM	++++ Akt2, IC50: 4.5 nM	++ Akt3, IC50: 16 nM		98+%
GSK-690693		++++ Akt1, IC50: 2 nM	+++ Akt2, IC50: 13 nM	+++ Akt3, IC50: 9 nM		99%+
AT7867		++ Akt1, IC50: 32 nM	++ Akt2, IC50: 17 nM	++ Akt3, IC50: 47 nM	PKA	99%+
AKT inhibitor VIII		++ Akt1, IC50: 58 nM	+ Akt2, IC50: 210 nM	+ Akt3, IC50: 2119 nM		98+%
MK-2206 2HCl		+++ Akt1, IC50: 8 nM	+++ Akt2, IC50: 12 nM	+ Akt3, IC50: 65 nM		99%+
Ipatasertib		++++ Akt1, IC50: 5 nM	++ Akt2, IC50: 18 nM	+++ Akt3, IC50: 8 nM		99%+
AT13148		++ Akt1, IC50: 38 nM	+ Akt2, IC50: 402 nM	++ Akt3, IC50: 50 nM	PKA	98+%
Capivasertib		++++ Akt1, IC50: 3 nM	+++ Akt2, IC50: 8 nM	+++ Akt3, IC50: 8 nM		99%+
A-674563 HCl		+++ Akt1, Ki: 11 nM			PKA	98%
CCT128930			+++ Akt2, IC50: 6 nM		PKA	98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Honokiol 生物活性

靶点

描述

Honokiol is a phenylpropanoid molecule, a biaryl-type lignan, present in the genus Magnolia. Neonatal rats, when injected with honokiol (10 mg/kg), acute pain response was subdued. And the application of 25 mg/kg honokiol to guinea pig models lowered the testosterone level^[3]. In addition,honokiol was able to prevent doxorubicin (Dox)-induced senescence of H9c2 cardiomyocytes ^[4]. Honokiol (10 mg/kg, orally) effectively reversed the hepatotoxicity indices elevations and abnormal histopathological changes induced by Concanavalin A (Con A)^[5].

Honokiol 细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源
HEK293 cells		Function assay		Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay, EC50=11.8 μM	20695472
HEK293 cells		Function assay	24-48 h	Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay	24959987
Hep-G2 cells		Cytotoxicity assay		Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined, IC50=16.5 μM	15582432
human A2780 cells		Proliferation assay		Antiproliferative activity against cisplatin-sensitive human A2780 cells by MTT assay, IC50=30.5 μM	19589678

Honokiol 参考文献

[1]Ishitsuka K, Hideshima T, et al. Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis. Blood. 2005 Sep 1;106(5):1794-800.

[2]Bai X, Cerimele F, et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem. 2003 Sep 12;278(37):35501-7.

[3]Wu XY, Zhang CX, Deng LC, Xiao J, Yuan X, Zhang B, Hou ZB, Sheng ZH, Sun L, Jiang QC, Zhao W. Overexpressed D2 Dopamine Receptor Inhibits Non-Small Cell Lung Cancer Progression through Inhibiting NF-κB Signaling Pathway. Cell Physiol Biochem. 2018;48(6):2258-2272. doi: 10.1159/000492644. Epub 2018 Aug 16. PMID: 30114693.

[4]Huang PP, Fu J, Liu LH, Wu KF, Liu HX, Qi BM, Liu Y, Qi BL. Honokiol antagonizes doxorubicin‑induced cardiomyocyte senescence by inhibiting TXNIP‑mediated NLRP3 inflammasome activation. Int J Mol Med. 2020 Jan;45(1):186-194. doi: 10.3892/ijmm.2019.4393. Epub 2019 Nov 1. PMID: 31746354; PMCID: PMC6889937.

[5]Elfeky MG, Mantawy EM, Gad AM, Fawzy HM, El-Demerdash E. Mechanistic aspects of antifibrotic effects of honokiol in Con A-induced liver fibrosis in rats: Emphasis on TGF-β/SMAD/MAPK signaling pathways. Life Sci. 2020 Jan 1;240:117096. doi: 10.1016/j.lfs.2019.117096. Epub 2019 Nov 21. PMID: 31760097.

Honokiol 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.75mL

0.75mL

0.38mL

18.77mL

3.75mL

1.88mL

37.55mL

7.51mL

3.75mL

Honokiol 技术信息

CAS号	35354-74-6
分子式	C₁₈H₁₈O₂
分子量	266.334

别名	NSC 293100
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 50 mg/mL(187.73 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

2% DMSO+40% PEG 300+2% Tween 80+water 2 mg/mL

细胞研究

细胞系	浓度	检测类型	检测时间	活动说明	数据源

HEK293 cells		Function assay		Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay, EC50=11.8 μM	20695472
HEK293 cells		Function assay	24-48 h	Agonist activity at human RXR-alpha expressed in HEK293 cells coexpressing with pCMX-beta-gal after 24 to 48 hrs by luciferase reporter gene assay	24959987
Hep-G2 cells		Cytotoxicity assay		Cytotoxicity of compound against human liver tumor cell line (Hep-G2) was determined, IC50=16.5 μM	15582432
human A2780 cells		Proliferation assay		Antiproliferative activity against cisplatin-sensitive human A2780 cells by MTT assay, IC50=30.5 μM	19589678
human A549 cell		Cytotoxicity assay	24 h	Cytotoxicity against human A549 cells after 24 hrs by MTS assay, IC50=12.51 μM	22533983
human A549 cells		Cytotoxicity assay		Cytotoxicity against human A549 cells after 72 hrs by MTS assay, IC50=7.75 μM	22533983
human CEM cells		Cytotoxicity assay		Cytotoxicity against human CEM cells, IC50=10.9 μM	17587572
human HepG2 cells		Proliferation assay	24 h	Antiproliferative activity against human HepG2 cells after 24 hrs by MTT assay, IC50=16.5 μM	21853991
human HT-29 cells		Cytotoxicity assay	72 h	Cytotoxicity against human HT-29 cells after 72 hrs by MTS assay, IC50=13.24 μM	22533983
human K562 cells		Proliferation assay		Antiproliferative activity against human K562 cells by MTT assay, IC50=21.1 μM	19589678
human PBM cells		Cytotoxicity assay		Cytotoxicity against human PBM cells, IC50=16.1 μM	17587572
human SH-SY5Y cells	10 μM	Function assay	30 mins	Neuroprotective activity in human SH-SY5Y cells assessed as inhibition of CHP and TBHP-induced cell death at 10 uM incubated for 30 mins prior to challenge measured after 3 hrs by MTT assay	22142539
human SPC-A1 cells		Proliferation assay		Antiproliferative activity against human SPC-A1 cells by MTT assay, IC50=36.1 μM	19589678
human UACC-903 cells		Cytotoxicity assay		Cytotoxicity against human UACC-903 cells after 72 hrs by MTS assay, IC50=5.1 μM	22533983
human UACC-903 cells		Cytotoxicity assay		Cytotoxicity against human UACC-903 cells after 24 hrs by MTS assay, IC50=7.45 μM	22533983
HUVEC cells	20 μM	Function assay	24 h	Antimigratory activity against human HUVEC cells at 20 uM after 24 hrs by wound-healing assay	21853991
Vero cells		Cytotoxicity assay		Cytotoxicity against Vero cells, IC50=22.5 μM	16722664
Vero E6 cells		Function assay		Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA, EC50=6.5 μM	17663539

和厚朴酚 /Honokiol {[allProObj[0].p_purity_real_show]}

Honokiol 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Honokiol 质控信息

Honokiol 生物活性

Honokiol 细胞研究

Honokiol 参考文献

Honokiol 实验方案

Honokiol 技术信息

最近浏览的产品

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和厚朴酚 /Honokiol {[allProObj[0].p_purity_real_show]}

Honokiol 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Honokiol 质控信息

Honokiol 生物活性

Honokiol 细胞研究

Honokiol 参考文献

Honokiol 实验方案

Honokiol 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Honokiol 纯度/质量文件产品仅供科研