大黄酚 /Chrysophanol
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货号：A253308
同义名：
Chrysophanic acid;NSC 37132
Chrysophanol, a natural anthraquinone isolated from Dianella longifolia, is an EGFR/mTOR pathway inhibitor.
Chrysophanol 化学结构
Chrysophanol 3D分子结构
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Chrysophanol 纯度/质量文件 产品仅供科研
货号：A253308
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Chrysophanol 质控信息
Chrysophanol 生物活性
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描述
Chrysophanol, a herbaceous perennial plant, belonging to the Polygonaceae family, has anticancer, antiviral, anti-diabetic and anti-inflammatory biological properties. In vivo , the saturation value of drug binding for chrysophanol was 0.53. The obtained LD50 value for oral toxicity of chrsyphanol was 2.5 g/kg[3] In vitro , chrysophanol inhibited the proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner. In addition, chrysophanol facilitated paclitaxel induced apoptosis and downregulated Bcl-2[4]
Chrysophanol 参考文献
[1] Lee MS, Cha EY, et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25(6):833-7.
[2] Semple SJ, Pyke SM, et al. In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus. Antiviral Res. 2001 Mar;49(3):169-78.
[3] Prateeksha, Yusuf MA, Singh BN, Sudheer S, Kharwar RN, Siddiqui S, Abdel-Azeem AM, Fernandes Fraceto L, Dashora K, Gupta VK. Chrysophanol: A Natural Anthraquinone with Multifaceted Biotherapeutic Potential. Biomolecules. 2019 Feb 18;9(2):68. doi: 10.3390/biom9020068. PMID: 30781696; PMCID: PMC6406798.
[4] Ren L, Li Z, Dai C, Zhao D, Wang Y, Ma C, Liu C. Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines. Mol Med Rep. 2018 Mar;17(3):4376-4382. doi: 10.3892/mmr.2018.8443. Epub 2018 Jan 17. PMID: 29344652; PMCID: PMC5802211.
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Chrysophanol 实验方案
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摩尔计算器
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.93mL
0.79mL
0.39mL
19.67mL
3.93mL
1.97mL
39.33mL
7.87mL
3.93mL
Chrysophanol 技术信息
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