JNK Inhibitor VIII | TCS JNK 6o | JNK Inhibitor | AmBeed-信号通路专用抑制剂

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JNK Inhibitor VIII {[allProObj[0].p_purity_real_show]}

货号：A872802 同义名： TCS JNK 6o;c-Jun N-terminal Kinase Inhibitor VIII

JNK Inhibitor VIII是一种c-Jun氨基末端激酶（JNK-1、-2、-3）抑制剂，Ki值分别为2 nM、4 nM和52 nM，IC50值分别为45 nM和160 nM（针对JNK-1和JNK-2）。

JNK Inhibitor VIII 化学结构
CAS号：894804-07-0

JNK Inhibitor VIII 3D分子结构
CAS号：894804-07-0

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JNK Inhibitor VIII 纯度/质量文件产品仅供科研

货号：A872802 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

JNK 亚型比较

产品名称	JNK ↓ ↑	JNK1 ↓ ↑	JNK2 ↓ ↑	JNK3 ↓ ↑	其他靶点	纯度
Mulberroside A	✔					99%+
Loureirin B	✔				Potassium Channel,Calcium Channel	99%+
Ginsenoside Re	✔				NF-κB	98%
(+)-(3R,8S)-Falcarindiol	✔				ERK,STAT	99%+
trans-Zeatin	✔				ERK,p38 MAPK	95+%
Urolithin B	✔				ERK,NF-κB	95%
Cucurbitacin IIb	✔				NF-κB	99%
Astragaloside IV	✔				Akt,mTOR,NF-κB	98%
NDMC101	✔					99%+
DB07268		++++ JNK1, IC50: 9 nM				99%+
SP600125	+ MKK4, IC50: 0.4 μM	+++ JNK1, IC50: 40 nM	+++ JNK2, IC50: 40 nM	+++ JNK3, IC50: 90 nM		98%
JNK-IN-7		++++ JNK1, IC50: 1.5 nM	++++ JNK2, IC50: 2 nM	++++ JNK3, IC50: 0.7 nM		99%
JNK-IN-8		++++ JNK1, IC50: 4.7 nM	+++ JNK2, IC50: 18.7 nM	++++ JNK3, IC50: 1 nM		99%+
3,3',5-Triiodo-L-thyronine		++ JNK1, Kd: 240 nM	++ JNK2, Kd: 290 nM	+++ JNK3, Kd: 66 nM		98%
IQ-1S free acid		+ JNK1, IC50: 390 nM	++ JNK2, IC50: 360 nM	+++ JNK3, IC50: 87 nM		99%
BI-78D3	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM		99%+
Bentamapimod		+++ JNK1, IC50: 80 nM	+++ JNK2, IC50: 90 nM	++ JNK3, IC50: 230 nM		98%
Resveratrol		+ JNK1, IC50: 50 μM				98%
Indirubin-3′-oxime		✔				99%+
SU3327	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM		99%+
JNK Inhibitor VIII		++++ JNK1, IC50: 45 nM JNK1, Ki: 2 nM	++++ JNK2, Ki: 4 nM JNK2, IC50: 160 nM	+++ JNK3, Ki: 52 nM		98%
Doramapimod			✔			99%+
RPI-1			✔			99%
TCS JNK 5a			++ JNK2, pIC50: 6.5	++ JNK3, pIC50: 6.7		98%
SP 600125, negative control			+ JNK2, IC50: 18 μM	+ JNK3, IC50: 24 μM		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

JNK Inhibitor VIII 生物活性

靶点

JNK1

JNK1, IC50:45 nM

JNK1, Ki:2 nM
JNK2

JNK2, Ki:4 nM

JNK2, IC50:160 nM
JNK3

JNK3, Ki:52 nM

描述

c-Jun N-terminal kinase-1 (JNK-1) is a member of the mitogen activated protein kinase (MAP kinase) family of enzymes responsible for the serine/threonine phosphorylation of intracellular targets. JNK-1 and the other JNK enzymes JNK-2 and JNK-3 are activated in response to cellular stresses and various cytokines, and they participate in the onset of apoptosis. TCS JNK 6o is a pan-JNK inhibitor with K_i values of 2, 4 and 52 nM for JNK-1, JNK-2 and JNK-3, respectively, and has IC₅₀ values of 45 and 160 nM for JNK-1 and JNK-2, respectively. In Sprague-Dawley rats, TCS JNK 6o showed a short half-life of roughly 1 h, with rapid clearance and barely measurable bioavailability. Microsomal incubation studies revealed that oxidative metabolism was very rapid with this compound^[2]. Moreover, inhibition of primordial follicle activation occurred in the presence of TCS JNK 6o when compared with controls (P < 0.05) after 2 days of culture^[3].

JNK Inhibitor VIII 参考文献

[1]Szczepankiewicz BG, et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.

[2]Szczepankiewicz BG, Kosogof C, Nelson LT, et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006;49(12):3563-3580

[3]Bertoldo MJ, Bernard J, Duffard N, et al. Inhibitors of c-Jun phosphorylation impede ovine primordial follicle activation. Mol Hum Reprod. 2016;22(5):338-349

JNK Inhibitor VIII 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.03mL

2.81mL

1.40mL

28.06mL

5.61mL

2.81mL

JNK Inhibitor VIII 技术信息

CAS号	894804-07-0
分子式	C₁₈H₂₀N₄O₄
分子量	356.376

别名	TCS JNK 6o;c-Jun N-terminal Kinase Inhibitor VIII;TCS JNK 6o
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Room Temperature

溶解度

DMSO: 250 mg/mL(701.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

JNK Inhibitor VIII {[allProObj[0].p_purity_real_show]}

JNK Inhibitor VIII 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

JNK Inhibitor VIII 质控信息

JNK Inhibitor VIII 生物活性

JNK Inhibitor VIII 参考文献

JNK Inhibitor VIII 实验方案

JNK Inhibitor VIII 技术信息

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JNK1	JNK1, IC50:45 nM JNK1, Ki:2 nM
JNK2	JNK2, Ki:4 nM JNK2, IC50:160 nM
JNK3	JNK3, Ki:52 nM

JNK Inhibitor VIII {[allProObj[0].p_purity_real_show]}

JNK Inhibitor VIII 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

JNK Inhibitor VIII 质控信息

JNK Inhibitor VIII 生物活性

JNK Inhibitor VIII 参考文献

JNK Inhibitor VIII 实验方案

JNK Inhibitor VIII 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

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B

C

F

G

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J

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JNK Inhibitor VIII 纯度/质量文件产品仅供科研