黄芪甲苷 IV /Astragaloside IV
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货号：A491011
同义名：
黄芪皂苷 IV
/ AS-IV;AST-IV
Astragaloside IV 是一种从黄芪中分离的活性皂苷类物质，能抑制 ERK1/2 和 JNK 的激活，并能下调 MDA-MB-231 乳腺癌细胞中的基质金属蛋白酶 MMP-2 和 MMP-9 的表达，具有抗肿瘤活性。
Astragaloside IV 化学结构
Astragaloside IV 3D分子结构
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Astragaloside IV 纯度/质量文件 产品仅供科研
货号：A491011
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Astragaloside IV 质控信息
Astragaloside IV 生物活性
靶点
描述
Astragaloside IV(AS-IV) is a saponin from Astragalus membranaceus. Oral administration of AS-IV (10 and 20 mg/kg) significantly attenuated memory impairment and neuroinflammation[3] [4] [5] [6]
Astragaloside IV 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT01553643
Intracranial Arterial Stenosis
Phase 4
Unknown
-
Taiwan
... 展开 >> China Medical University Hospital
Recruiting
Taiching, Taiwan
Contact: Chung Hsiang Liu, MD. 收起 <<
Astragaloside IV 参考文献
[1] Li M, Li H, et al. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2017 Feb 3;639:114-119.
[2] Gui J, Chen R, et al. Remission of CVB3-induced myocarditis with Astragaloside IV treatment requires A20 (TNFAIP3) up-regulation. J Cell Mol Med. 2015 Apr;19(4):850-64.
[3] Li M, Li H, Fang F, Deng X, Ma S. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2017 Feb 3;639:114-119. doi: 10.1016/j.neulet.2016.12.046. Epub 2016 Dec 21. PMID: 28011393.
[4] Liu L, Li SJ, Zhou Y. [Protective effect of astragaloside IV against acute liver failure in experimental mice]. Zhonghua Gan Zang Bing Za Zhi. 2016 Oct 20;24(10):772-777. Chinese. doi: 10.3760/cma.j.issn.1007-3418.2016.10.011. PMID: 27938564.
[6] Jiang K, Lu Q, Li Q, Ji Y, Chen W, Xue X. Astragaloside IV inhibits breast cancer cell invasion by suppressing Vav3 mediated Rac1/MAPK signaling. Int Immunopharmacol. 2017 Jan;42:195-202. doi: 10.1016/j.intimp.2016.10.001. Epub 2016 Dec 5. PMID: 27930970.
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Astragaloside IV 实验方案
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工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.27mL
0.25mL
0.13mL
6.37mL
1.27mL
0.64mL
12.74mL
2.55mL
1.27mL
Astragaloside IV 技术信息
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