Urolithin B is a natural product with anti-proliferative and antioxidant activity, which can penetrate the blood-brain barrier and may have neuroprotective effects against Alzheimer’s Disease.It inhibitsaromatase activity in human placental microsomes and aromatase-sensitive MCF-7 (MCF-7aro) human breast cancer cells when used at concentrations of 47 and 4.7 µM, respectively.
Urolithin B (30-100 μM; 24 h) exhibits anti-inflammatory properties in LPS-stimulated BV2 microglia by modulating pro- and anti-inflammatory molecules. It suppresses NF-κB and AP-1 signaling while upregulating AMPK and downregulating the Akt, JNK, and ERK signaling pathways in LPS-stimulated BV2 cells[1]. Urolithin B (15 μM; 24 h) promotes the growth and differentiation of C2C12 muscle ducts through increased protein synthesis and suppression of the ubiquitin-proteasome pathway[2].
体内研究
Urolithin B (50 mg/kg; ip; once daily for 4 days) suppresses microglial activation in the brains of LPS-injected mice under neuroinflammatory conditions[1].
Urolithin B (10 μg/day; mini-osmotic pump delivery, 28 days) triggers muscle hypertrophy and diminishes muscle atrophy following sciatic nerve transection in mice[2].
体外研究
Urolithin B (30-100 μM; 24 h) exhibits anti-inflammatory properties in LPS-stimulated BV2 microglia by modulating pro- and anti-inflammatory molecules. It suppresses NF-κB and AP-1 signaling while upregulating AMPK and downregulating the Akt, JNK, and ERK signaling pathways in LPS-stimulated BV2 cells[1].
Urolithin B (15 μM; 24 h) promotes the growth and differentiation of C2C12 muscle ducts through increased protein synthesis and suppression of the ubiquitin-proteasome pathway[2].
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