Ginsenoside Re | Panaxoside Re;Ginsenoside B2;NSC 308877;Chikusetsusaponin Ivc;Sanchinoside Re | 人参皂甙 Re | Other Compounds | Sugar | JNK | Amyloid-β | NF-κB | Panax | Saccharides and Glycosides

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人参皂苷 Re /Ginsenoside Re 98%

货号：A149220 同义名： 人参皂甙 Re / Panaxoside Re;Ginsenoside B2

Ginsenoside Re is a panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions.

Ginsenoside Re 化学结构
CAS号：52286-59-6

Ginsenoside Re 3D分子结构
CAS号：52286-59-6

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Ginsenoside Re 纯度/质量文件产品仅供科研

货号：A149220 标准纯度： 98% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

JNK 亚型比较
NF-κB 亚型比较

产品名称	JNK ↓ ↑	JNK1 ↓ ↑	JNK2 ↓ ↑	JNK3 ↓ ↑	其他靶点	纯度
Mulberroside A	✔					99%+
Loureirin B	✔				Calcium Channel,Potassium Channel	99%+
Ginsenoside Re	✔				NF-κB	98%
(+)-(3R,8S)-Falcarindiol	✔				STAT,ERK	99%+
trans-Zeatin	✔				p38 MAPK,ERK	95+%
Urolithin B	✔				NF-κB,ERK	95%
Cucurbitacin IIb	✔				NF-κB	98+%
Astragaloside IV	✔				NF-κB,Akt,mTOR	98%
NDMC101	✔					99%+
DB07268		++++ JNK1, IC50: 9 nM				99%+
SP600125	+ MKK4, IC50: 0.4 μM	+++ JNK1, IC50: 40 nM	+++ JNK2, IC50: 40 nM	+++ JNK3, IC50: 90 nM		98%
JNK-IN-7		++++ JNK1, IC50: 1.5 nM	++++ JNK2, IC50: 2 nM	++++ JNK3, IC50: 0.7 nM		98+%
JNK-IN-8		++++ JNK1, IC50: 4.7 nM	+++ JNK2, IC50: 18.7 nM	++++ JNK3, IC50: 1 nM		99%+
3,3',5-Triiodo-L-thyronine		++ JNK1, Kd: 240 nM	++ JNK2, Kd: 290 nM	+++ JNK3, Kd: 66 nM		98%
IQ-1S free acid		+ JNK1, IC50: 390 nM	++ JNK2, IC50: 360 nM	+++ JNK3, IC50: 87 nM		98%
BI-78D3	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM	++ JNK, IC50: 280 nM		99%+
Bentamapimod		+++ JNK1, IC50: 80 nM	+++ JNK2, IC50: 90 nM	++ JNK3, IC50: 230 nM		98%
Resveratrol		+ JNK1, IC50: 50 μM				98%
Indirubin-3′-oxime		✔				99%+
SU3327	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM	+ JNK, IC50: 0.7 μM		99%+
JNK Inhibitor VIII		++++ JNK1, Ki: 2 nM JNK1, IC50: 45 nM	++++ JNK2, Ki: 4 nM JNK2, IC50: 160 nM	+++ JNK3, Ki: 52 nM		98%
Doramapimod			✔			99%+
RPI-1			✔			97%
TCS JNK 5a			++ JNK2, pIC50: 6.5	++ JNK3, pIC50: 6.7		98%
SP 600125, negative control			+ JNK2, IC50: 18 μM	+ JNK3, IC50: 24 μM		97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	NF-κB ↓ ↑	其他靶点	纯度
Pyrrolidinedithiocarbamate ammonium	✔		98%
QNZ	++++ NF-κB, IC50: 11 nM		99%+
Sodium 4-Aminosalicylate Dihydrate	✔		98%
Sodium Salicylate	✔		95%
Parthenolide	✔	p53	97% HPLC
JSH-23	+ NF-κB, IC50: 7.1 μM		98%
Phenethyl caffeate	✔		98%
Andrographolide	✔		98+%
Curcumin	✔	HDAC,Nrf2	98%
SC75741	+++ NF-κB, EC50: 200 nM		99%+
CBL0137 HCl	++ NF-κB, EC50: 0.47 μM	p53	99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ginsenoside Re 生物活性

靶点

描述

Ginsenoside Re is an extract from Panax notoginseng. Ginsenoside Re decreased the Aβ(β-amyloid protein) levels in N2a/APP695 cells. Ginsenoside Re decreased the BACE1 (β-site amyloid precursor protein cleaving enzyme 1) mRNA and protein levels and inhibited BACE1 activity in the N2a/APP695 cells. Ginsenoside Re significantly increased the PPARγ protein and mRNA levels^[3]. Ginsenoside Re can improve isoproterenol-induced myocardial fibrosis and heart failure by regulation of the TGF-β1(transforming growth factor)/Smad3 pathway^[4]. GRe protects MA-induced (methamphetamine) dopaminergic neurotoxicity via upregulatgion of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated NK1 R (neurokinin 1 receptor) ^[5]. Moreover, ginsenoside Re-dependent upregulation of GPX4 (glutathione peroxidase 4) reduces oxidative stress and thereby alleviates 6-OHDA(6-hydroxydopamine)-induced neuronal damage^[6]. After GS-Re treatment, the vessel lumen of injured vessels showed significant increases in the GS-Re 25.0 and 50.0 mg/kg/d (intermediate- and high-dose) groups according to H.E. staining. GS-Re can suppress balloon injury-induced vascular neointimal hyperplasia by inhibiting VSMC proliferation^[7].

Ginsenoside Re 参考文献

[1]Wang L, Yuan D, et al. Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury. Cell Mol Neurobiol. 2015 Aug;35(6):827-40.

[2]Sukrittanon S, Watanapa WB, Ruamyod K. Ginsenoside Re enhances small-conductance Ca(2+)-activated K(+) current in human coronary artery endothelial cells. Life Sci. 2014 Oct 12;115(1-2):15-21.

[3]Cao G, Su P, Zhang S, et al. Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells. Eur J Pharmacol. 2016;793:101-108

[4]Wang QW, Yu XF, Xu HL, Zhao XZ, Sui DY. Ginsenoside Re Improves Isoproterenol-Induced Myocardial Fibrosis and Heart Failure in Rats. Evid Based Complement Alternat Med. 2019;2019:3714508. Published 2019 Jan 1

[5]Dang DK, Shin EJ, Kim DJ, et al. Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor. J Neuroinflammation. 2018;15(1):52. Published 2018 Feb 21

[6]Lee GH, Lee WJ, Hur J, Kim E, Lee HG, Seo HG. Ginsenoside Re Mitigates 6-Hydroxydopamine-Induced Oxidative Stress through Upregulation of GPX4. Molecules. 2020;25(1):188. Published 2020 Jan 2

[7]Gao Y, Gao CY, Zhu P, et al. Ginsenoside Re inhibits vascular neointimal hyperplasia in balloon-injured carotid arteries through activating the eNOS/NO/cGMP pathway in rats. Biomed Pharmacother. 2018;106:1091-1097

Ginsenoside Re 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.06mL

0.21mL

0.11mL

5.28mL

1.06mL

0.53mL

10.56mL

2.11mL

1.06mL

Ginsenoside Re 技术信息

CAS号	52286-59-6
分子式	C₄₈H₈₂O₁₈
分子量	947.154

别名	人参皂甙 Re ;Panaxoside Re;Ginsenoside B2;NSC 308877;Chikusetsusaponin Ivc;Sanchinoside Re
运输	蓝冰

存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(52.79 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

人参皂苷 Re /Ginsenoside Re 98%

Ginsenoside Re 纯度/质量文件产品仅供科研

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Ginsenoside Re 质控信息

Ginsenoside Re 生物活性

Ginsenoside Re 参考文献

Ginsenoside Re 实验方案

Ginsenoside Re 技术信息

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人参皂苷 Re /Ginsenoside Re 98%

Ginsenoside Re 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Ginsenoside Re 质控信息

Ginsenoside Re 生物活性

Ginsenoside Re 参考文献

Ginsenoside Re 实验方案

Ginsenoside Re 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

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C

F

G

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J

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Ginsenoside Re 纯度/质量文件产品仅供科研