人参皂苷 Re /Ginsenoside Re {[allProObj[0].p_purity_real_show]}
货号：A149220同义名：
人参皂甙 Re
/ Panaxoside Re;Ginsenoside B2
Ginsenoside Re is a panaxatriol saponin that has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions.
Ginsenoside Re is an extract from Panax notoginseng. Ginsenoside Re decreased the Aβ(β-amyloid protein) levels in N2a/APP695 cells. Ginsenoside Re decreased the BACE1 (β-site amyloid precursor protein cleaving enzyme 1) mRNA and protein levels and inhibited BACE1 activity in the N2a/APP695 cells. Ginsenoside Re significantly increased the PPARγ protein and mRNA levels[3]. Ginsenoside Re can improve isoproterenol-induced myocardial fibrosis and heart failure by regulation of the TGF-β1(transforming growth factor)/Smad3 pathway[4]. GRe protects MA-induced (methamphetamine) dopaminergic neurotoxicity via upregulatgion of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated NK1 R (neurokinin 1 receptor) [5]. Moreover, ginsenoside Re-dependent upregulation of GPX4 (glutathione peroxidase 4) reduces oxidative stress and thereby alleviates 6-OHDA(6-hydroxydopamine)-induced neuronal damage[6]. After GS-Re treatment, the vessel lumen of injured vessels showed significant increases in the GS-Re 25.0 and 50.0 mg/kg/d (intermediate- and high-dose) groups according to H.E. staining. GS-Re can suppress balloon injury-induced vascular neointimal hyperplasia by inhibiting VSMC proliferation[7].
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